Effect of Carica papaya leaves suspension in thrombocytopenia patients infected with dengue: A case control Study

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Shah Zeb
Jamshaid Ahmad
Awais Abid
Mohammed Aljeldah
Basim R. Al shammari
Ameen S.S. Alwashmi
Mohammed Garout
Bashayer M. AlShehail
Waleed Al Abdulmonem
Thamir S. Alsaeed
Amal K. Hassoueh
Ali A. Rabaan


Prevalence of Dengue virus; Carica papaya leaves suspension; IgG/IgM; NS1; FDA; GRAS; WHO; Experimental study


This study aimed to determine the prevalence of local dengue viral strains circulating in New Darband and isolate the thrombocytopenia-associated dengue strain. Platelet volume screening was conducted on dengue-infected patients before and after consumption of Carica papaya leaves suspension. Among 3733 positive patients, 23.5% females tested positive for IgG, IgM, 17.5% for IgG/NS1, and 40.6% for IgM/NS1. In males, 29% tested positive for IgG, IgM, 11.5% for IgG/NS1, and IgM/NS1 22.2% and 27.5% for NS1. Age groups analyzed included 18-30 years, 30-40 years, 40-50 years, and 50-60 years. The administration of Carica papaya leaves suspension resulted in a significant increase in platelet count in dengue-infected patients, with no adverse effects observed during the study. This indicates the potential of Carica papaya in protecting and regulating platelets against dengue virus complications. Additionally, the study suggested that NS1 is a reliable seromarker for accurately detecting dengue infection with thrombocytopenia. Carica papaya leaves suspension shows promise as a suitable remedy for increasing platelet count in dengue-infected patients. However, further high-quality evidence from large clinical trials is necessary to determine its applicability.

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