Main Article Content

Ali A. Rabaan
Fatimah S. Alshahrani
Muhammad A. Halwani
Majed S. Nassar
Muhammed A. Bakhrebah
Wesam H. Abdulaal
Mohammed Garout
Hatem M. Alhani
Shamsah H. Al-Ahmed
Maha A. Al-Mozaini
Meshal K. AlFonaisan
Sana A. Alshaikh
Abdulnasir M. Alotaibi
Huseyin Tombuloglu
David Chinaecherem Innocent
Kirnpal Kaur Banga Singh


Children, Infants, Health concerns, Coronavirus, therapeutic targets, mutations


The coronavirus disease (COVID-19) is a viral respiratory disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 infection in pediatric population has not been studied much because of the comparatively less number of cases among children during COVID- 19 pandemic. As less number of cases in pediatric population has been documented, less is known
about the epidemiology of virus among children. However, the other coronaviruses are comparatively more understood. As the SARS-CoV-2 has progressed, the mutations have been occurred and reported. The current study explores mutants’ infection in infants and children, as well as concerns, problems, management, and mitigation measures based on therapeutic targets of the virus. The articles
were searched using keywords (COVID-19 among children, SARS-CoV-2 infection among children, pediatric infections, coronavirus therapies for children, therapeutic management of hospitalized pediatric patients) from Google scholar, PubMed, Scopus, MDPI and Web of Science data bases. The most important outcomes and clinical features of viral infections in children and adolescents were
studied. The current study also explores the rate of infection, clinical manifestations, clinical findings, and transmission dynamics for SARS-CoV-2 in children. Drug repositioning might be the sole answer to the outbreak of unexpected contagious illnesses because of the delayed mechanism of new drug expansion. The current review systematically compared the proteins expressed by the SARS-CoV-2
genes to those produced by other coronaviruses. This research will also provide novel lead compounds and targets for additional SARS-CoV-2 in both in-vitro and in-vivo investigations. The new insights for medications already in clinical trials, and possibly new drug repositioning techniques will be known to treat SARS-CoV-2 infections in more better ways.

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1. Saif, L.J.; Wang, Q.; Vlasova, A.N.; Jung, K.; Xiao, S. Coronaviruses. Diseases of swine 2019, 488-523.
2. Chen, Y.; Liu, Q.; Guo, D. Emerging coronaviruses: genome structure, replication, and pathogenesis. Journal of medical virology 2020, 92, 418-423.
3. Ahmed, N.; Rizvi, A.; Naeem, A.; Saleem, W.; Ahmed, A.; Parveen, S.; Ilyas, M. COVID-19 and public awareness. The Professional Medical Journal 2020, 27, 1710-1716.
4. Suzuki, T.; Otake, Y.; Uchimoto, S.; Hasebe, A.; Goto, Y. Genomic characterization and phylogenetic classification of bovine coronaviruses through whole genome sequence analysis. Viruses 2020, 12, 183.
5. Ali, Z.; Jatoi, M.A.; Al-Wraikat, M.; Ahmed, N.; Li, J. Time to enhance immunity via functional foods and supplements: Hope for SARS-CoV-2 outbreak. Altern. Ther. Health Med 2021, 27, 30-44.
6. Cui, J.; Li, F.; Shi, Z.-L. Origin and evolution of pathogenic coronaviruses. Nature reviews microbiology 2019, 17, 181-192.
7. Song, R.; Han, B.; Song, M.; Wang, L.; Conlon, C.P.; Dong, T.; Tian, D.; Zhang, W.; Chen, Z.; Zhang, F. Clinical and epidemiological features of COVID-19 family clusters in Beijing, China. Journal of Infection 2020, 81, e26-e30.
8. Zhou, P.; Fan, H.; Lan, T.; Yang, X.-L.; Shi, W.-F.; Zhang, W.; Zhu, Y.; Zhang, Y.-W.; Xie, Q.-M.; Mani, S. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature 2018, 556, 255-258.
9. Li, Q.; Guan, X.; Wu, P.; Wang, X.; Zhou, L.; Tong, Y.; Ren, R.; Leung, K.S.; Lau, E.H.; Wong, J.Y. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England journal of medicine 2020.
10. Ren, L.-L.; Wang, Y.-M.; Wu, Z.-Q.; Xiang, Z.-C.; Guo, L.; Xu, T.; Jiang, Y.-Z.; Xiong, Y.; Li, Y.-J.; Li, X.-W. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chinese medical journal 2020, 133, 1015-1024.
11. Al-Rabiaah, A.; Temsah, M.-H.; Al-Eyadhy, A.A.; Hasan, G.M.; Al-Zamil, F.; Al-Subaie, S.; Alsohime, F.; Jamal, A.; Alhaboob, A.; Al-Saadi, B. Middle East Respiratory Syndrome-Corona Virus (MERS-CoV) associated stress among medical students at a university teaching hospital in Saudi Arabia. Journal of infection and public health 2020, 13, 687-691.
12. Ashour, H.M.; Elkhatib, W.F.; Rahman, M.M.; Elshabrawy, H.A. Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks. Pathogens 2020, 9, 186.
13. Zhu, N.; Zhang, D.; Wang, W.; Li, X.; Yang, B.; Song, J.; Zhao, X.; Huang, B.; Shi, W.; Lu, R. A novel coronavirus from patients with pneumonia in China, 2019. New England journal of medicine 2020.
14. Almuzaini, Y.; Alsohime, F.; Subaie, S.A.; Temsah, M.H.; Alsofayan, Y.; Alamri, F.; Alahmari, A.; Alahdal, H.; Sonbol, H.; Almaghrabi, R.; et al. Clinical profiles associated with SARS-CoV-2 infection and complications from coronavirus disease-2019 in children from a national registry in Saudi Arabia. Annals of thoracic medicine 2021, 16, 280-286, doi:10.4103/atm.atm_709_20.
15. Liguoro, I.; Pilotto, C.; Bonanni, M.; Ferrari, M.E.; Pusiol, A.; Nocerino, A.; Vidal, E.; Cogo, P. SARS-COV-2 infection in children and newborns: a systematic review. European journal of pediatrics 2020, 179, 1029-1046.
16. Dong, E.; Du, H.; Gardner, L. An interactive web-based dashboard to track COVID-19 in real time. The Lancet infectious diseases 2020, 20, 533-534.
17. Alsohime, F.; Temsah, M.H.; Al-Nemri, A.M.; Somily, A.M.; Al-Subaie, S. COVID-19 infection prevalence in pediatric population: Etiology, clinical presentation, and outcome. Journal of infection and public health 2020, 13, 1791-1796, doi:10.1016/j.jiph.2020.10.008.
18. Senniyappan, M.; Garadi, S.; Deol, R. Impact of COVID-19 on Children: Indian Perspective and Concerns: Are we Sentient? International Journal of Medicine and Public Health 2021, 11.
19. Wu, Z.; McGoogan, J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama 2020, 323, 1239-1242.
20. Lambertini, M.; Toss, A.; Passaro, A.; Criscitiello, C.; Cremolini, C.; Cardone, C.; Loupakis, F.; Viscardi, G.; Meattini, I.; Dieci, M.V. Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists’ perspective. ESMO open 2020, 5, e000759.
21. Onder, G.; Rezza, G.; Brusaferro, S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. Jama 2020, 323, 1775-1776.
22. Eastin, C.; Eastin, T. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China: Dong Y, Mo X, Hu Y, et al. Pediatrics. 2020. Journal of Emergency Medicine 2020, 58, 712-713.
23. Schwartz, D.A. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Archives of pathology & laboratory medicine 2020, 144, 799-805.
24. Peng, Z.; Wang, J.; Mo, Y.; Duan, W.; Xiang, G.; Yi, M.; Bao, L.; Shi, Y. Unlikely SARS-CoV-2 vertical transmission from mother to child: a case report. Journal of infection and public health 2020, 13, 818-820.
25. Zeng, L.; Xia, S.; Yuan, W.; Yan, K.; Xiao, F.; Shao, J.; Zhou, W. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA pediatrics 2020, 174, 722-725.
26. Openshaw, J.J.; Travassos, M.A. COVID-19 outbreaks in US immigrant detention centers: the urgent need to adopt CDC guidelines for prevention and evaluation. Clinical Infectious Diseases 2021, 72, 153-154.
27. Schoeman, D.; Fielding, B.C. Coronavirus envelope protein: current knowledge. Virology journal 2019, 16, 1-22.
28. Yusof, W.; Irekeola, A.A.; Wada, Y.; Engku Abd Rahman, E.N.S.; Ahmed, N.; Musa, N.; Khalid, M.F.; Rahman, Z.A.; Hassan, R.; Yusof, N.Y. A global mutational profile of SARS-CoV-2: a systematic review and meta-analysis of 368,316 COVID-19 patients. Life 2021, 11, 1224.
29. Tian, D.; Sun, Y.; Xu, H.; Ye, Q. The emergence and epidemic characteristics of the highly mutated SARS‐CoV‐2 Omicron variant. Journal of Medical Virology 2022, 94, 2376-2383.
30. Sevinc Temizkan, S.; Alkan, F. Bovine coronavirus infections in Turkey: molecular analysis of the full-length spike gene sequences of viruses from digestive and respiratory infections. Archives of virology 2021, 166, 2461-2468.
31. Huang, Y.; Yang, C.; Xu, X.-f.; Xu, W.; Liu, S.-w. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica 2020, 41, 1141-1149.
32. Cao, Y.; Yang, R.; Wang, W.; Jiang, S.; Yang, C.; Liu, N.; Dai, H.; Lee, I.; Meng, X.; Yuan, Z. Probing the formation, structure and free energy relationships of M protein dimers of SARS-CoV-2. Computational and Structural Biotechnology Journal 2022, 20, 573-582.
33. Wang, X.; Yao, H.; Xu, X.; Zhang, P.; Zhang, M.; Shao, J.; Xiao, Y.; Wang, H. Limits of detection of 6 approved RT–PCR kits for the novel SARS-Coronavirus-2 (SARS-CoV-2). Clinical chemistry 2020, 66, 977-979.
34. Hasöksüz, M.; Kilic, S.; Saraç, F. Coronaviruses and sars-cov-2. Turkish journal of medical sciences 2020, 50, 549-556.
35. Chan, J.F.-W.; Kok, K.-H.; Zhu, Z.; Chu, H.; To, K.K.-W.; Yuan, S.; Yuen, K.-Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging microbes & infections 2020, 9, 221-236.
36. Flerlage, T.; Boyd, D.F.; Meliopoulos, V.; Thomas, P.G.; Schultz-Cherry, S. Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract. Nature Reviews Microbiology 2021, 19, 425-441.
37. Ahmed, N.; Kalil, M.N.A.; Yusof, W.; Bakar, M.A.A.; Sjahid, A.S.; Hassan, R.; Fauzi, M.H.; Yean, C.Y. A Performance Assessment Study of Different Clinical Samples for Rapid COVID-19 Antigen Diagnosis Tests. Diagnostics 2022, 12, 847.
38. Kalil, M.N.A.; Yusof, W.; Ahmed, N.; Fauzi, M.H.; Bakar, M.A.A.; Sjahid, A.S.; Hassan, R.; Yean Yean, C. Performance Validation of COVID-19 Self-Conduct Buccal and Nasal Swabs RTK-Antigen Diagnostic Kit. Diagnostics 2021, 11, 2245.
39. Holshue, M.L.; DeBolt, C.; Lindquist, S.; Lofy, K.H.; Wiesman, J.; Bruce, H.; Spitters, C.; Ericson, K.; Wilkerson, S.; Tural, A. First case of 2019 novel coronavirus in the United States. New England journal of medicine 2020.
40. Guan, W.-j.; Ni, Z.-y.; Hu, Y.; Liang, W.-h.; Ou, C.-q.; He, J.-x.; Liu, L.; Shan, H.; Lei, C.-l.; Hui, D.S. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv 2020.
41. Dai, M.; Liu, D.; Liu, M.; Zhou, F.; Li, G.; Chen, Z.; Zhang, Z.; You, H.; Wu, M.; Zheng, Q. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 OutbreakPatients with Cancer in SARS-COV-2 Infection. Cancer discovery 2020, 10, 783-791.
42. Jin, Y.-H.; Cai, L.; Cheng, Z.-S.; Cheng, H.; Deng, T.; Fan, Y.-P.; Fang, C.; Huang, D.; Huang, L.-Q.; Huang, Q. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research 2020, 7, 1-23.
43. Ahmed, N.; Khan, M.; Saleem, W.; Karobari, M.I.; Mohamed, R.N.; Heboyan, A.; Rabaan, A.A.; Mutair, A.A.; Alhumaid, S.; Alsadiq, S.A. Evaluation of bi-lateral co-infections and antibiotic resistance rates among COVID-19 patients. Antibiotics 2022, 11, 276.
44. Yang, D.; Leibowitz, J.L. The structure and functions of coronavirus genomic 3′ and 5′ ends. Virus research 2015, 206, 120-133.
45. Liu, W.; Zhang, Q.; Chen, J.; Xiang, R.; Song, H.; Shu, S.; Chen, L.; Liang, L.; Zhou, J.; You, L. Detection of Covid-19 in children in early January 2020 in Wuhan, China. New England Journal of Medicine 2020, 382, 1370-1371.
46. Yu, F.; Du, L.; Ojcius, D.M.; Pan, C.; Jiang, S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes and infection 2020, 22, 74-79.
47. Corman, V.M.; Landt, O.; Kaiser, M.; Molenkamp, R.; Meijer, A.; Chu, D.K.; Bleicker, T.; Brünink, S.; Schneider, J.; Schmidt, M.L. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance 2020, 25, 2000045.
48. Mahmood, T.B.; Saha, A.; Hossan, M.I.; Mizan, S.; Arman, S.A.S.; Chowdhury, A.S. A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia. Current research in microbial sciences 2021, 2, 100065.
49. Anis, S.; Khan, M.M.; Ali, Z.; Khan, A.; Arsalan, H.M.; Naeem, S.; Saleem, I.; Qamar, S.; Khan, M.M.; Ahmad, A. Novel corona virus disease (COVID-19): An updated review on epidemiology, pathogenicity, clinical course, treatments, migrant health concerns and risk factors predictions. Pak. J. Pharm. Sci 2021, 34, 1807-1822.
50. Bonam, S.R.; Kotla, N.G.; Bohara, R.A.; Rochev, Y.; Webster, T.J.; Bayry, J. Potential immuno-nanomedicine strategies to fight COVID-19 like pulmonary infections. Nano today 2021, 36, 101051.
51. Chandra, T.B.; Verma, K.; Singh, B.K.; Jain, D.; Netam, S.S. Coronavirus disease (COVID-19) detection in chest X-ray images using majority voting based classifier ensemble. Expert systems with applications 2021, 165, 113909.
52. Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet 2020, 395, 497-506.
53. Chung, M.; Bernheim, A.; Mei, X.; Zhang, N.; Huang, M.; Zeng, X.; Cui, J.; Xu, W.; Yang, Y.; Fayad, Z.A. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology 2020.
54. Li, W.; Cui, H.; Li, K.; Fang, Y.; Li, S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatric radiology 2020, 50, 796-799.
55. Ooi, G.C.; Khong, P.L.; Müller, N.L.; Yiu, W.C.; Zhou, L.J.; Ho, J.C.; Lam, B.; Nicolaou, S.; Tsang, K.W. Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients. Radiology 2004, 230, 836-844.
56. Das, K.M.; Lee, E.Y.; Enani, M.A.; AlJawder, S.E.; Singh, R.; Bashir, S.; Al-Nakshbandi, N.; AlDossari, K.; Larsson, S.G. CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus. American Journal of Roentgenology 2015, 204, 736-742.
57. Yao, H.; Fu, J.; Shu, Q.; Chen, Z.; Wu, N.; Ye, S.; Wang, W.; Ni, Y.; Shang, S.; Li, W. The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. International Journal of Infectious Diseases 2021, 111, 347-353.
58. Pandey, U.; Yee, R.; Shen, L.; Judkins, A.R.; Bootwalla, M.; Ryutov, A.; Maglinte, D.T.; Ostrow, D.; Precit, M.; Biegel, J.A. High prevalence of SARS-CoV-2 genetic variation and D614G mutation in pediatric patients with COVID-19. In Proceedings of the Open Forum Infectious Diseases, 2021; p. ofaa551.
59. Plante, J.A.; Liu, Y.; Liu, J.; Xia, H.; Johnson, B.A.; Lokugamage, K.G.; Zhang, X.; Muruato, A.E.; Zou, J.; Fontes-Garfias, C.R. Spike mutation D614G alters SARS-CoV-2 fitness. Nature 2021, 592, 116-121.
60. Li, Q.; Wu, J.; Nie, J.; Zhang, L.; Hao, H.; Liu, S.; Zhao, C.; Zhang, Q.; Liu, H.; Nie, L. The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity. Cell 2020, 182, 1284-1294. e1289.
61. Koyama, T.; Platt, D.; Parida, L. Variant analysis of SARS-CoV-2 genomes. Bulletin of the World Health Organization 2020, 98, 495.
62. Toyoshima, Y.; Nemoto, K.; Matsumoto, S.; Nakamura, Y.; Kiyotani, K. SARS-CoV-2 genomic variations associated with mortality rate of COVID-19. Journal of human genetics 2020, 65, 1075-1082.
63. Alteri, C.; Scutari, R.; Costabile, V.; Colagrossi, L.; Yu La Rosa, K.; Agolini, E.; Lanari, V.; Chiurchiù, S.; Romani, L.; Markowich, A.H. Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation. Scientific reports 2022, 12, 1-12.
64. Du, W.; Yu, J.; Wang, H.; Zhang, X.; Zhang, S.; Li, Q.; Zhang, Z. Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection 2020, 48, 445-452.
65. Coronavirus disease 2019 in children—United States, February 12–April 2, 2020. MMWR Morb Mortal Wkly Rep. Centers for Disease Control Prevention. . 2020, 69, 422-426.
66. Sun, D.; Li, H.; Lu, X.-X.; Xiao, H.; Ren, J.; Zhang, F.-R.; Liu, Z.-S. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World Journal of Pediatrics 2020, 16, 251-259.
67. Zhu, H.; Wang, L.; Fang, C.; Peng, S.; Zhang, L.; Chang, G.; Xia, S.; Zhou, W. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational pediatrics 2020, 9, 51.
68. Wang, D.; Ju, X.; Xie, F.; Lu, Y.; Li, F.; Huang, H.; Fang, X.; Li, Y.; Wang, J.; Yi, B. Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China. Zhonghua er ke za zhi 2020, 269-274.
69. Yang, R.; Gui, X.; Xiong, Y. Comparison of clinical characteristics of patients with asymptomatic vs symptomatic coronavirus disease 2019 in Wuhan, China. JAMA network open 2020, 3, e2010182-e2010182.
70. Jones, T.C.; Mühlemann, B.; Veith, T.; Biele, G.; Zuchowski, M.; Hofmann, J.; Stein, A.; Edelmann, A.; Corman, V.M.; Drosten, C. An analysis of SARS-CoV-2 viral load by patient age. MedRxiv 2020.
71. Kim, M.M.; Murthy, S.; Goldman, R.D. Post–COVID-19 multisystem inflammatory syndrome in children. Canadian Family Physician 2021, 67, 594-596.
72. Loncharich, M.; Klusewitz, S.; Jones, O. Post-COVID-19 Multisystem Inflammatory Syndrome in Children and Adults: What Happens After Discharge? Cureus 2022, 14.
73. Merticariu, C.I.; Merticariu, M.; Cobzariu, C.; Mihai, M.M.; Dragomir, M.S. Pediatric inflammatory multisystem syndrome induced Panuveitis associated with SARS-CoV-2 infection: What the Ophthalmologists need to know. Romanian Journal of Ophthalmology 2022, 66, 198.
74. Brzyska, A.; Bogucka, J.; Bojarska, M.; Domańska, N. Manifestations of the pediatric multisystem inflammatory syndrome temporally related with SARS-CoV-2 (PIMS) in the gastrointestinal, cardiovascular, nervous and respiratory systems. Journal of Education, Health and Sport 2022, 12, 34-43.
75. Zimmermann, P.; Curtis, N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. The Pediatric infectious disease journal 2020, 39, 355.
76. Gu, J.; Han, B.; Wang, J. COVID-19: gastrointestinal manifestations and potential fecal–oral transmission. Gastroenterology 2020, 158, 1518-1519.
77. Cimolai, N. Features of enteric disease from human coronaviruses: Implications for COVID‐19. Journal of Medical Virology 2020, 92, 1834-1844.
78. Xu, Y.; Li, X.; Zhu, B.; Liang, H.; Fang, C.; Gong, Y.; Guo, Q.; Sun, X.; Zhao, D.; Shen, J. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nature medicine 2020, 26, 502-505.
79. Zhang, C.; Gu, J.; Chen, Q.; Deng, N.; Li, J.; Huang, L.; Zhou, X. Clinical characteristics of 34 children with coronavirus disease-2019 in the west of China: a multiple-center case series. MedRxiv 2020.
80. Lu, Q.; Shi, Y. Coronavirus disease (COVID‐19) and neonate: What neonatologist need to know. Journal of medical virology 2020, 92, 564-567.
81. Wang, L.; Shi, Y.; Xiao, T.; Fu, J.; Feng, X.; Mu, D.; Feng, Q.; Hei, M.; Hu, X.; Li, Z. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection. Annals of translational medicine 2020, 8.
82. Henry, B.M.; Lippi, G.; Plebani, M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clinical Chemistry and Laboratory Medicine (CCLM) 2020, 58, 1135-1138.
83. Sahu, K.K.; Cerny, J. A review on how to do hematology consults during COVID-19 pandemic. Blood Reviews 2021, 47, 100777.
84. Xiong, T.-Y.; Redwood, S.; Prendergast, B.; Chen, M. Coronaviruses and the cardiovascular system: acute and long-term implications. European heart journal 2020.
85. Kordzadeh-Kermani, E.; Khalili, H.; Karimzadeh, I. Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19). Future microbiology 2020, 15, 1287-1305.
86. Macias, A.E.; McElhaney, J.E.; Chaves, S.S.; Nealon, J.; Nunes, M.C.; Samson, S.I.; Seet, B.T.; Weinke, T.; Yu, H. The disease burden of influenza beyond respiratory illness. Vaccine 2021, 39, A6-A14.
87. Silverstein, W.K.; Stroud, L.; Cleghorn, G.E.; Leis, J.A. First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia. The Lancet 2020, 395, 734.
88. Xia, W.; Shao, J.; Guo, Y.; Peng, X.; Li, Z.; Hu, D. Clinical and CT features in pediatric patients with COVID‐19 infection: different points from adults. Pediatric pulmonology 2020, 55, 1169-1174.
89. Buonsenso, D.; Piano, A.; Raffaelli, F.; Bonadia, N.; Donati, K.D.G.; Franceschi, F. Novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak. Eur Rev Med Pharmacol Sci 2020, 24, 2776-2780.
90. Fang, Y.; Zhang, H.; Xie, J.; Lin, M.; Ying, L.; Pang, P.; Ji, W. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology 2020.
91. Centers for Disease Control Prevention. Stay Up to Date with COVID-19 Vaccines Including Boosters. Accessed on: 15-09-2022. Available at: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-up-to-date.html. 2022.
92. Centers for Disease Control Prevention. COVID-19 Vaccines for People Who Are Moderately or Severely Immunocompromised. Accessed on: 18-09-2022. Available at: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/immuno.html. 2022.
93. Raoult, D.; Zumla, A.; Locatelli, F.; Ippolito, G.; Kroemer, G. Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses. Cell stress 2020, 4, 66.
94. Phua, J.; Weng, L.; Ling, L.; Egi, M.; Lim, C.-M.; Divatia, J.V.; Shrestha, B.R.; Arabi, Y.M.; Ng, J.; Gomersall, C.D. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. The lancet respiratory medicine 2020, 8, 506-517.
95. Chen, Z.-M.; Fu, J.-F.; Shu, Q.; Chen, Y.-H.; Hua, C.-Z.; Li, F.-B.; Lin, R.; Tang, L.-F.; Wang, T.-L.; Wang, W. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World journal of pediatrics 2020, 16, 240-246.
96. Zumla, A.; Hui, D.S.; Azhar, E.I.; Memish, Z.A.; Maeurer, M. Reducing mortality from 2019-nCoV: host-directed therapies should be an option. The Lancet 2020, 395, e35-e36.
97. Chiotos, K.; Hayes, M.; Kimberlin, D.W.; Jones, S.B.; James, S.H.; Pinninti, S.G.; Yarbrough, A.; Abzug, M.J.; MacBrayne, C.E.; Soma, V.L. Multicenter initial guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2. Journal of the Pediatric Infectious Diseases Society 2020, 9, 701-715.
98. World Health Organization. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance. Accessed on 13 March 2020.; 2020.
99. Lu, X.; Zhang, L.; Du, H.; Zhang, J.; Li, Y.Y.; Qu, J.; Zhang, W.; Wang, Y.; Bao, S.; Li, Y. SARS-CoV-2 infection in children. New England Journal of Medicine 2020, 382, 1663-1665.
100. Li, Y.; Guo, F.; Cao, Y.; Li, L.; Guo, Y. Insight into COVID‐2019 for pediatricians. Pediatric pulmonology 2020, 55, E1-E4.
101. Salako, A.; Odubela, O.; Musari-Martins, T.; Ezemelue, P.; Gbaja-Biamila, T.; Opaneye, B.; James, A.; Oforomeh, O.; Osuolale, K.; Musa, A. Prevalence and Presentation of Paediatric Coronavirus Disease 2019 in Lagos, Nigeria. International Journal of Pediatrics 2021, 2021.
102. Zheng, F.; Liao, C.; Fan, Q.-h.; Chen, H.-b.; Zhao, X.-g.; Xie, Z.-g.; Li, X.-l.; Chen, C.-x.; Lu, X.-x.; Liu, Z.-s. Clinical characteristics of children with coronavirus disease 2019 in Hubei, China. Current medical science 2020, 40, 275-280.
103. Park, J.Y.; Han, M.S.; Park, K.U.; Kim, J.Y.; Choi, E.H. First pediatric case of coronavirus disease 2019 in Korea. Journal of Korean medical science 2020, 35.
104. Liu, Y.; Yang, Y.; Zhang, C.; Huang, F.; Wang, F.; Yuan, J.; Wang, Z.; Li, J.; Li, J.; Feng, C. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences 2020, 63, 364-374.
105. Yu, X.; Sun, X.; Cui, P.; Pan, H.; Lin, S.; Han, R.; Jiang, C.; Fang, Q.; Kong, D.; Zhu, Y. Epidemiological and clinical characteristics of 333 confirmed cases with coronavirus disease 2019 in Shanghai, China. Transboundary and emerging diseases 2020, 67, 1697-1707.
106. Wang, Y.; Wang, Y.; Chen, Y.; Qin, Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID‐19) implicate special control measures. Journal of medical virology 2020, 92, 568-576.
107. Zhang, G.X.; Zhang, A.M.; Huang, L.; Cheng, L.Y.; Liu, Z.X.; Peng, X.L.; Wang, H.W. Twin girls infected with SARS-CoV-2. Zhongguo dang dai er ke za zhi= Chinese journal of contemporary pediatrics 2020, 22, 221-225.
108. Wei, M.; Yuan, J.; Liu, Y.; Fu, T.; Yu, X.; Zhang, Z.-J. Novel coronavirus infection in hospitalized infants under 1 year of age in China. Jama 2020, 323, 1313-1314.
109. Lou, M.X.X.; Shi, C.X.; Zhou, C.C.; Tian, M.Y.S. Three children who recovered from novel coronavirus 2019 pneumonia. Journal of Paediatrics and Child Health 2020.

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