A NARRATIVE REVIEW ON SARS-COV-2 INFECTION IN PEDIATRICS: CONCERNS, CHALLENGES, MANAGEMENT, AND MITIGATION STRATEGIES

Main Article Content

Ali A. Rabaan
Fatimah S. Alshahrani
Muhammad A. Halwani
Majed S. Nassar
Muhammed A. Bakhrebah
Wesam H. Abdulaal
Mohammed Garout
Hatem M. Alhani
Shamsah H. Al-Ahmed
Maha A. Al-Mozaini
Meshal K. AlFonaisan
Sana A. Alshaikh
Abdulnasir M. Alotaibi
Huseyin Tombuloglu
David Chinaecherem Innocent
Kirnpal Kaur Banga Singh

Keywords

Children, Infants, Health concerns, Coronavirus, therapeutic targets, mutations

Abstract

The coronavirus disease (COVID-19) is a viral respiratory disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 infection in pediatric population has not been studied much because of the comparatively less number of cases among children during COVID- 19 pandemic. As less number of cases in pediatric population has been documented, less is known
about the epidemiology of virus among children. However, the other coronaviruses are comparatively more understood. As the SARS-CoV-2 has progressed, the mutations have been occurred and reported. The current study explores mutants’ infection in infants and children, as well as concerns, problems, management, and mitigation measures based on therapeutic targets of the virus. The articles
were searched using keywords (COVID-19 among children, SARS-CoV-2 infection among children, pediatric infections, coronavirus therapies for children, therapeutic management of hospitalized pediatric patients) from Google scholar, PubMed, Scopus, MDPI and Web of Science data bases. The most important outcomes and clinical features of viral infections in children and adolescents were
studied. The current study also explores the rate of infection, clinical manifestations, clinical findings, and transmission dynamics for SARS-CoV-2 in children. Drug repositioning might be the sole answer to the outbreak of unexpected contagious illnesses because of the delayed mechanism of new drug expansion. The current review systematically compared the proteins expressed by the SARS-CoV-2
genes to those produced by other coronaviruses. This research will also provide novel lead compounds and targets for additional SARS-CoV-2 in both in-vitro and in-vivo investigations. The new insights for medications already in clinical trials, and possibly new drug repositioning techniques will be known to treat SARS-CoV-2 infections in more better ways.

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