Comparative diagnostic analysis, frequency, severity, and seroprevalence of Dengue fever

Main Article Content

Sameer Zafar
Samia Yousaf
Maria Irshad Chohan
Shah Zeb
Mohammed Garout
Muhammad Zahid Ali
Muhammad A. Halwani
Mohammed Aljeldah
Ahlam Alynbiawi
Saleh A. Alshamrani
Sarah A. Algosaibi
Roua A. Alsubki
Abdulmonem A. Alsaleh
Ali A. Rabaan

Keywords

Dengue Fever, Virus serotypes, diagnostics

Abstract

The study involved a total of 450 participants, with 359 males and 91 females. Out of a larger group of 4820 individuals, 4170 tested positive for dengue, while 650 tested negative. In the subsequent analysis, the negative cases were excluded, added only the positive cases. Signs and symptoms of dengue were analyzed, including fever (p = 0.007), rapid and weak pulse, pallor or cool skin, rashes (p = 0.005), and headache (p = 0.001). The mean difference between genders was 2085, with a standard deviation of 771 and a variance of 594441.The 95% confidence interval was 2,085 ± 1,068.551 (±51.25%), and the p-value was 0.002. The mean differences for specific markers related to dengue were as follows: IgM = 548.5, IgG = 294.5, NS1 = 949, and IgG/IgM = 293. The standard deviations for these markers were IgM = 71.5, IgG = 23.5, NS1 = 738, and IgG/IgM = 128. The 95% confidence intervals were calculated as 1.960σx̄, 521.25 ± 320.176 (±61.42%), with a variance of V = 213479.75 and a p-value of 0.009. The overall mean difference for dengue serotypes was 521.2, with a standard deviation of 350.4 and a variance of 122845.18. The 95% confidence interval was 521.25 ± 242.879 (±46.60%), with a p-value of 0.007. The mean±SD values for hemoglobin = 16.0±2.41, platelets = 71250.2±24321.5, and hematocrit = 47.3±7.22. In dengue hemorrhagic fever, the mean±SD values were hemoglobin = 17.2±2.83, platelets = 32412.5±27530.2, and hematocrit = 66.5±9.72. The study highlighted the endemic nature and seroprevalence of dengue within the vicinity of the civil hospital. The highest seroprevalence of dengue, indicated by the NS1 marker, was observed in males, while the lowest prevalence was seen in females, possibly due to more males working in tire shops and labor-intensive jobs.

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References

1. Jajarmi A, Arshad S, Baleanu D. A new fractional modelling and control strategy for the outbreak of dengue fever. Physica A: Statistical Mechanics and its Applications. 2019;535:122524.
2. Shah K, Jarad F, Abdeljawad T. On a nonlinear fractional order model of dengue fever disease under Caputo-Fabrizio derivative. Alexandria Engineering Journal. 2020;59(4):2305-13.
3. Nonyong P, Ekalaksananan T, Phanthanawiboon S, Aromseree S, Phadungsombat J, Nakayama EE, et al. Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018. 2021;16(9):e0257460.
4. Li C, Lu Y, Liu J, Wu X. Climate change and dengue fever transmission in China: evidences and challenges. Science of the Total Environment. 2018;622:493-501.
5. Harapan H, Michie A, Mudatsir M, Sasmono RT, Imrie A. Epidemiology of dengue hemorrhagic fever in Indonesia: analysis of five decades data from the National Disease Surveillance. BMC research notes. 2019;12(1):1-6.
6. Gaye A, Wang E, Vasilakis N, Guzman H, Diallo D, Talla C, et al. Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa. PLoS neglected tropical diseases. 2019;13(2):e0007043.
7. Bhatt P, Sabeena SP, Varma M, Arunkumar GJCM. Current understanding of the pathogenesis of dengue virus infection. 2021;78(1):17-32.
8. Kosasih CE, Lukman M, Solehati T, Mediani HSJL, Review C. Effect of dengue hemorrhagic fever health education on knowledge and attitudes, in elementary school children in West Java, Indonesia. 2021;5(S1):191-200.
9. Leowattana W, Leowattana TJWJoM-A. Dengue hemorrhagic fever and cardiac involvement. 2021;9(3):286-96.
10. Quirino-Teixeira AC, Andrade FB, Pinheiro MBM, Rozini SV, Hottz ED. Platelets in dengue infection: more than a numbers game. Platelets. 2021:1-8.
11. Rajapakse SJJoE, Trauma, Shock. Dengue shock. 2011;4(1):120.
12. Mahmood S, Nabeel H, Hafeez S, Zahra U, Nazeer H. Seroprevalence of dengue IgG antibodies among healthy adult population in Lahore, Pakistan. International Scholarly Research Notices. 2013;2013.
13. Ali A, ur Rehman H, Nisar M, Rafique S, Ali S, Hussain A, et al. Seroepidemiology of dengue fever in Khyber Pakhtunkhawa, Pakistan. International Journal of Infectious Diseases. 2013;17(7):e518-e23.
14. Muhammad I, Khan J, Iqbal H, Rahman H, Muhammad A. Seroprevalence and epidemiological status of dengue viral infection in remote areas of Pakistan. Asian Pacific Journal of Tropical Disease. 2016;6(10):776-7.
15. Ahmed S, Ali SR, Tabassum F. Seroprevalence of Dengue Virus IgG among Children 1-15 Years, Selected from an Urban Population in Karachi, Pakistan: Population Based Study. Open Journal of Pediatrics. 2015;5(02):128.
16. Zameer S, Soomro S, Baig S, Rubeen R, Sharafat S. Seasonal variation and Seroprevalence of Dengue fever in Karachi, Pakistan. Journal of Muhammad Medical College, Mirpurkhas. 2017;8(1):12-5.
17. Quadri S, Khan M, Fatima G, Siddiqui N. Association of Seroprevalance with Dempgrahic Characterstics of Dengue Viral Infection in a Megacity, Karachi, Pakistan. Annals ASH KM&DC. 2017;22:81-8.
18. Mukhtar MU, Mukhtar M, Iqbal N. Dengue fever is an emerging public health concern in the city of Multan, Pakistan: its seroprevalence and associated risk factors. Microbiology and immunology. 2018;62(11):729-31.

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