Comparative diagnostic analysis, frequency, severity, and seroprevalence of Dengue fever

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Sameer Zafar
Samia Yousaf
Maria Irshad Chohan
Shah Zeb
Mohammed Garout
Muhammad Zahid Ali
Muhammad A. Halwani
Mohammed Aljeldah
Ahlam Alynbiawi
Saleh A. Alshamrani
Sarah A. Algosaibi
Roua A. Alsubki
Abdulmonem A. Alsaleh
Ali A. Rabaan


Dengue Fever, Virus serotypes, diagnostics


The study involved a total of 450 participants, with 359 males and 91 females. Out of a larger group of 4820 individuals, 4170 tested positive for dengue, while 650 tested negative. In the subsequent analysis, the negative cases were excluded, added only the positive cases. Signs and symptoms of dengue were analyzed, including fever (p = 0.007), rapid and weak pulse, pallor or cool skin, rashes (p = 0.005), and headache (p = 0.001). The mean difference between genders was 2085, with a standard deviation of 771 and a variance of 594441.The 95% confidence interval was 2,085 ± 1,068.551 (±51.25%), and the p-value was 0.002. The mean differences for specific markers related to dengue were as follows: IgM = 548.5, IgG = 294.5, NS1 = 949, and IgG/IgM = 293. The standard deviations for these markers were IgM = 71.5, IgG = 23.5, NS1 = 738, and IgG/IgM = 128. The 95% confidence intervals were calculated as 1.960σx̄, 521.25 ± 320.176 (±61.42%), with a variance of V = 213479.75 and a p-value of 0.009. The overall mean difference for dengue serotypes was 521.2, with a standard deviation of 350.4 and a variance of 122845.18. The 95% confidence interval was 521.25 ± 242.879 (±46.60%), with a p-value of 0.007. The mean±SD values for hemoglobin = 16.0±2.41, platelets = 71250.2±24321.5, and hematocrit = 47.3±7.22. In dengue hemorrhagic fever, the mean±SD values were hemoglobin = 17.2±2.83, platelets = 32412.5±27530.2, and hematocrit = 66.5±9.72. The study highlighted the endemic nature and seroprevalence of dengue within the vicinity of the civil hospital. The highest seroprevalence of dengue, indicated by the NS1 marker, was observed in males, while the lowest prevalence was seen in females, possibly due to more males working in tire shops and labor-intensive jobs.

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