Human epidermal growth factor receptor 2 (Her2/Neu) immunoexpression in gastrointestinal adenocarcinomas: A clinicopathological study

Ayesha; Satish L Belagatti; Srinivasa Murthy Venkataramanappa; Muhammad Absar; Hajir AlSaihati; Abdulmonem A. Alsaleh; Saleh Al-Abdulhadi; Ahmed Alsayyah; Sawsan A. Almatroud; Ali A. Rabaan

doi:10.47750/jptcp.2023.30.15.053

Ayesha

Senior resident in MS Ramiah medical college and Research hospital

Satish L Belagatti

Department of Pathology ESICMC and PGIMSR Bangalore

Srinivasa Murthy Venkataramanappa

Department of Pathology ESICMC and PGIMSR Bangalore

Muhammad Absar

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia

Hajir AlSaihati

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia

Abdulmonem A. Alsaleh

Clinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia

Saleh Al-Abdulhadi

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Riyadh 11942, Saudi Arabia

Ahmed Alsayyah

Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Sawsan A. Almatroud

Flowcytometry laboratory, King Fahad University hospital, Al Khobar 34445, Saudi Arabia

Ali A. Rabaan

Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia

Keywords

Gastric adenocarcinoma; colorectal adenocarcinomas; Her2neu; IHC; age; site; TNM STAGE

Abstract

One of the major causes of cancer-related mortality is gastrointestinal (GI) cancer. The outcomes of surgical resection of advanced cancer are still poor, despite the fact that it has improved the overall prognosis of patients with these malignancies. As a consequence, it is essential to look for predictors of disease survival and therapeutic response. The current study was conducted with the aims to study the clinicopathological parameters, to study HER2 /neu expression and to look out the association between the expression of HER2/neu and other clinicopathological parameters like age, gender, tumor location (whether gastric/gastro esophageal junction), histological pattern (Laurens classification), grade and stage of adenocarcinomas. A total of 100 cases of GI adenocarcinoma were studied for a period of 6 years (retrospective and prospective) in ESI PGIMSR, Bangalore. IHC analysis for HER2neu was performed and the association of immune expression markers were studied with clinicopathological and prognostic markers. Gastric Adenocarcinomas were seen mostly in the age group of 41-50yrs and more in male population and colorectal in the age group of 51-60yrs and in female population. Diffuse type in gastric adenocarcinomas and mucinous type in colorectal adenocarcinomas were the most common type in our study. Among Gastric adenocarcinomas, majority were poorly differentiated and in colorectal adenocarcinomas moderately differentiated are the most common type. There was direct correlation between the presenting symptoms among the gastric and colorectal adenocarcinomas (<0.04%). Overall, Her2neu positivity was found in 39.6% of gastric adenocarcinomas and 17.3% of colonic adenocarcinomas. In general, GI Adenocarcinomas showed stronger Her2neu positivity in comparison to colorectal carcinomas. Her2neu positivity correlated with the type of gastro-esophageal carcinomas (p<0.03%). The present study emphasizes the role of Her2 expression in Gastro intestinal adenocarcinomas in quantifying the subset of patients that could benefit from targeted therapy, thereby improving clinical outcome in these patients.

Abstract 139 | PDF Downloads 142

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Published

Jun 22, 2023

DOI https://doi.org/10.47750/jptcp.2023.30.15.053

How to Cite

Ayesha, Satish L Belagatti, Srinivasa Murthy Venkataramanappa, Muhammad Absar, Hajir AlSaihati, Abdulmonem A. Alsaleh, Saleh Al-Abdulhadi, Ahmed Alsayyah, Sawsan A. Almatroud, & Ali A. Rabaan. (2023). Human epidermal growth factor receptor 2 (Her2/Neu) immunoexpression in gastrointestinal adenocarcinomas: A clinicopathological study. Journal of Population Therapeutics and Clinical Pharmacology, 30(15), 465–474. https://doi.org/10.47750/jptcp.2023.30.15.053