Human epidermal growth factor receptor 2 (Her2/Neu) immunoexpression in gastrointestinal adenocarcinomas: A clinicopathological study

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Satish L Belagatti
Srinivasa Murthy Venkataramanappa
Muhammad Absar
Hajir AlSaihati
Abdulmonem A. Alsaleh
Saleh Al-Abdulhadi
Ahmed Alsayyah
Sawsan A. Almatroud
Ali A. Rabaan


Gastric adenocarcinoma; colorectal adenocarcinomas; Her2neu; IHC; age; site; TNM STAGE


One of the major causes of cancer-related mortality is gastrointestinal (GI) cancer. The outcomes of surgical resection of advanced cancer are still poor, despite the fact that it has improved the overall prognosis of patients with these malignancies. As a consequence, it is essential to look for predictors of disease survival and therapeutic response. The current study was conducted with the aims to study the clinicopathological parameters, to study HER2 /neu expression and to look out the association between the expression of HER2/neu and other clinicopathological parameters like age, gender, tumor location (whether gastric/gastro esophageal junction), histological pattern (Laurens classification), grade and stage of adenocarcinomas. A total of 100 cases of GI adenocarcinoma were studied for a period of 6 years (retrospective and prospective) in ESI PGIMSR, Bangalore. IHC analysis for HER2neu was performed and the association of immune expression markers were studied with clinicopathological and prognostic markers. Gastric Adenocarcinomas were seen mostly in the age group of 41-50yrs and more in male population and colorectal in the age group of 51-60yrs and in female population. Diffuse type in gastric adenocarcinomas and mucinous type in colorectal adenocarcinomas were the most common type in our study. Among Gastric adenocarcinomas, majority were poorly differentiated and in colorectal adenocarcinomas moderately differentiated are the most common type. There was direct correlation between the presenting symptoms among the gastric and colorectal adenocarcinomas (<0.04%). Overall, Her2neu positivity was found in 39.6% of gastric adenocarcinomas and 17.3% of colonic adenocarcinomas. In general, GI Adenocarcinomas showed stronger Her2neu positivity in comparison to colorectal carcinomas. Her2neu positivity correlated with the type of gastro-esophageal carcinomas (p<0.03%). The present study emphasizes the role of Her2 expression in Gastro intestinal adenocarcinomas in quantifying the subset of patients that could benefit from targeted therapy, thereby improving clinical outcome in these patients.

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