SENSITIVITY OF ESCHERICHIA COLI TO FOSFOMYCIN IN PATIENTS WITH URINARY TRACT INFECTION
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Keywords
Urinary tract infection, Escherichia coli, Antibiotic sensitivity, Fosfomycin
Abstract
Objectives: To determine the sensitivity of E. coli to fosfomycin in patients with urinary tract infection.
Methods: This cross-sectional study was conducted at Khyber Teaching Hospital, Peshawar, Pakistan, from 21st Oct, 2016 to 30th April, 2017 and comprised urine specimens. Biochemical techniques were used to identify Escherichia coli and antibiotic susceptibility was determined by Kirby-Bauer disk diffusion and minimum inhibitory concentration methods. SPSS 23 was used for data analysis.
Results: Out of 396 patients with positive urine culture for E. coli, urinary tract infection was predominant in Female population, i-e 303 (76.5%) females and 93(23.5%) males. Male to Female ratio was found to be of 1:3.2. The sensitivity of E. coli to fosfomycin was 93.9%.
Conclusion: Escherichia coli has a very low level of resistance against fosfomycin therefore it is suggested to be a very good choice as first line empirical treatment for urinary tract infection.
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Naeemullah
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Akhtar Nawab
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Hameed Badshah
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Zia Ullah
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Irshad Ali
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Fawad Khalid
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Faisal Ahmad
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College
Sarab Jeet Singh
Department of Medicine Saidu Group of Teaching Hospital and Saidu Medical College