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Muhammad Sajid Rafiq Abbasi
Khawar Sultan
Adnan Mushtaq
Humayun Saleem
Qudsia Umaira Khan
Maham Tariq
Amna Akbar
Sabahat Tasneem
Sarosh Khan Jadoon


Lupus Nephritis, SLE, Renal biopsy, ISN/RPS 2003, Serum urea, Proteinuria


Background: The most common symptom of systematic lupus erythematosus (SLE) is lupus nephritis (LN), with an incidence of 50–70%. Kidney biopsy, which enables histology-based classification in accordance with World Health Organization (WHO) standards declared in 1982, is the main method used to examine LN. This study aimed to classify LN according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification system and determine the prevalence of different classes.

Methods: The Nephrology Department at a tertiary care hospital in Islamabad, Pakistan, conducted a retrospective observational study between February 2012 and April 2018. The study included adult participants (age > 18 years) with a confirmed diagnosis of lupus nephritis and individuals who had undergone renal biopsy. Patient data were obtained from hospital records and analyzed thoroughly.

Results: A total of 256 biopsies were examined, and 40 cases of LN were confirmed. It is more prevalent in females (7:1), with class IV having the highest incidence rate. There was no statistically significant link between LN and urea, but proteinuria and creatinine values were significant.

Conclusion: It is essential to promptly recognize renal failure in SLE patients. Lupus nephritis can be diagnosed and treated using a kidney biopsy.

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