TRANSFUSION TRANSMISSIBLE INFECTIONS AMONG BETA THALASSEMIA PATIENTS: CHALLENGES AND INSIGHTS
Main Article Content
Keywords
Blood, Transfusion, Transmittable, Infections, Thalassemia
Abstract
The blood transfusion is the most common procedure in healthcare facilities which saves millions of lives every year. However, it is the main source of disease transmission among the people who undergo this procedure more frequently. The patients suffering from thalassemia are categorized among the most frequent blood recipients. Therefore, the chance of transmitting the transfusion-transmittable Infections (TTIs) such as hepatitis B, hepatitis C, acquired immunodeficiency syndrome, syphilis, and malaria are more common in these patients as compared to others. Due to increasing reports related to the improper pre-transfusion screenings and increasing number of hepatitis B and hepatitis C patients in Pakistan, it seems that the incidence of TTIs is also increasing especially among the patients experiencing multiple transfusions. Therefore, the present project was designed to study the prevalence of TTIs in patients suffering from thalassemia in Faisalabad Pakistan. The total 200 blood samples from beta-thalassemia patients were collected from the Faisalabad region of Pakistan. Male patients were 130 (65%) and females were 70 (35%). The blood group of O+ve has high frequency and rate of infection 47(33.09%) as compare to other ABO blood groups B+ve 40 (28.16%), A+ve 23 (16.19%), B-negative 13 (9.15%), AB+ve 10 (7.04%) and O-negative 07 (4.92%). Similarly, the prevalence rate of HCV was more detected as compare to other TTIs as 111(55.5%). HIV rate was 20 (10%). Malaria Parasites was 7(3.5%), Syphilis was 3 (1.5%) and HBsAg was 01 (0.5%) in beta-thalassemia patients. It also shows the high prevalence rate of infections in the age group of 6-10 years’ patients that have transfused blood 50-100 pints 93 (65.49%). So these rate of infections can be controlled by a proper screening of blood and educate people about thalassemia.
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19. Helmi, N., Bashir, M., Shireen, A., & Ahmed, I. M. (2017). Thalassemia review: features, dental considerations and management. Electronic physician, 9(3), 4003
20. Hossain, B., Khan, W., Tawfique, M., & Rahman, F. (2018). Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh. Journal of Enam Medical College, 8(1), 16-19
21. Hussain, H., Iqbal, R., Khan, M. H., Iftikhar, B., Aziz, S., & Burki, F. K. (2008). Prevalence of hepatitis C in beta thalassaemia major. Gomal J Med Sci, 6(2), 87-90
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23. Jafroodi, M., Davoudi-Kiakalayeh, A., Mohtasham-Amiri, Z., Pourfathollah, A. A., & Haghbin, A. (2015). Trend in prevalence of hepatitis C virus infection among β-thalassemia major patients: 10 years of experience in Iran. International journal of preventive medicine, 6
24. Khalil, S., Khan, H. S., & Akhtar, P. (2016). Status of Hepatitis B and C in Beta Thalassemia Major Patients. Journal of Islamabad Medical & Dental College, 5(2), 71-73
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26. Khattak, A. A., Venkatesan, M., Nadeem, M. F., Satti, H. S., Yaqoob, A., Strauss, K., . . . Plowe, C. V. (2013). Prevalence and distribution of human Plasmodium infection in Pakistan. Malaria journal, 12(1), 297
27. Kidson‐Gerber, G. L., Francis, S., & Lindeman, R. (2008). Management and clinical outcomes of transfusion‐dependent thalassaemia major in an Australian tertiary referral clinic. Medical Journal of Australia, 188(2), 72-75
28. Korenromp, E. L., Mahiané, S. G., Nagelkerke, N., Taylor, M. M., Williams, R., Chico, R. M., . . . Rowley, J. (2018). Syphilis prevalence trends in adult women in 132 countries–estimations using the Spectrum Sexually Transmitted Infections model. Scientific reports, 8(1), 11503
29. Kumar, S., Agnihotri, S., Marwaha, R., & Sehgal, S. (1994). HIV infection in multi-transfused thalassemic children. Indian pediatrics, 31, 1438-1438
30. Lavanchy, D., & Kane, M. (2016). Global epidemiology of hepatitis B virus infection Hepatitis B virus in human diseases (pp. 187-203): Springer.
31. Lazarus, J. V., Palayew, A., van Damme, P., Hendrickx, G., Peck, R., & Colombo, M. (2019). Eliminating hepatitis C in Europe. Lancet Gastroenterol Hepatol, 4(5), 335-336
32. Lyon, A. R., Bossone, E., Schneider, B., Sechtem, U., Citro, R., Underwood, S. R., . . . Akashi, Y. J. (2016). Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 18(1), 8-27
33. Madmoli, M., Madmoli, Y., Rahmati, P., Adavi, A., Yousefi, N., Gheisari, Z., & Abbaszade Aliabad, M. (2017). Quality of Life and Some Related Factors in Patients with Beta Thalassemia Major in Southwest Iran. Journal of Client-Centered Nursing Care, 3(2), 139-146
34. Majid, A., Rehman, M., Ahmad, T., Ali, A., Ali, S., & Ali, S. (2016). Prevalence of malaria in human population of district Mardan, Pakistan. World J. Zool, 11, 63-66
35. Mansour, A. K., Aly, R. M., Abdelrazek, S. Y., Elghannam, D. M., Abdelaziz, S. M., Shahine, D. A., . . . Darwish, A. M. (2012). Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients. Hematology/oncology and stem cell therapy, 5(1), 54-59
36. Minosse, C., Selleri, M., Giombini, E., Bartolini, B., Capobianchi, M. R., Cerilli, S., . . . McPhee, F. (2018). Clinical and virological properties of hepatitis C virus genotype 4 infection in patients treated with different direct-acting antiviral agents. Infection and drug resistance, 11, 2117
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Jan 25, 2024
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Muhammad Usman, Ali Raza, Kiran Khadam, Muhammad Mudassar, & Muhammad Akram. (2024). TRANSFUSION TRANSMISSIBLE INFECTIONS AMONG BETA THALASSEMIA PATIENTS: CHALLENGES AND INSIGHTS. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 3038-3049. https://doi.org/10.53555/avar7g66
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Author Biographies
Muhammad Usman
Department of Medical Laboratory Technology, Riphah International University Faisalabad, Pakistan
Ali Raza
Institute of Microbiology, Government College University Faisalabad, Pakistan
Kiran Khadam
District Headquarter Hospital Chiniot, Pakistan
Muhammad Mudassar
College of Allied Health Professionals, Faculty of Medical Sciences, Government College University Faisalabad, Pakistan
Muhammad Akram
Department of Eastern Medicine, Faculty of Medical Sciences, Government College University Faisalabad, Pakistan
How to Cite
Muhammad Usman, Ali Raza, Kiran Khadam, Muhammad Mudassar, & Muhammad Akram. (2024). TRANSFUSION TRANSMISSIBLE INFECTIONS AMONG BETA THALASSEMIA PATIENTS: CHALLENGES AND INSIGHTS. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 3038-3049. https://doi.org/10.53555/avar7g66