EXAMINING THE THERAPEUTIC IMPACT OF PASSIFLORA NITIDA KUNTH EXTRACT ON NEURODEGENERATION IN AN EXPERIMENTAL ALZHEIMER'S MODEL

Main Article Content

Ali Raza
Ali Imran Mallhi
Waqas Ahmad
Dr. Zareen Naz
Diro Ajema Cheka
V. Sampath

Keywords

Alzheimer's, passion fruit bush, passionflower nitida, cognitive deficit, neuroprotection

Abstract

Background: Alzheimer's disease (AD) is a debilitating neurodegenerative disorder marked by progressive memory loss, cognitive decline, and neuronal degeneration. Addressing the cholinergic deficit is a key strategy for managing AD, involving inhibition of acetylcholine (ACh) degradation and administration of nicotinic receptor agonists. Medicinal plants, with their diverse bioactive compounds, are being investigated globally for potential AD treatments. Passiflora Nitida Kunth, a herbaceous plant native to the Amazon region, has previously demonstrated neuroprotective and antioxidant properties, making it a promising candidate for AD therapy.


Objective: This study aimed to assess the therapeutic potential of the hydroethanolic extract of Passiflora Nitida Kunth in a non-transgenic preclinical model of Alzheimer's-like cognitive impairment induced by streptozotocin (STZ).


Methods: The Alzheimer's-like cognitive impairment model was established by intracerebroventricular administration of STZ, followed by treatments with passionflower extract, galantamine (a standard AD medication), and saline. General behavior was evaluated, and histological analysis of neuronal tissue was conducted, specifically quantifying intact cell numbers in the CA1 and CA3 hippocampal regions.


Results: Preliminary findings indicate that Passiflora Nitida Kunth extract exhibited neuroprotective effects in the STZ-induced AD model. The behavioral assessments demonstrated potential improvements, suggesting a positive impact on cognitive function. Histological analysis revealed a notable preservation of intact cells in the hippocampal regions CA1 and CA3, highlighting the extract's potential in mitigating neuronal damage associated with AD.


Conclusion: The hydroethanolic extract of Passiflora Nitida Kunth emerges as a promising candidate for Alzheimer's disease therapy, demonstrating neuroprotective effects and potential cognitive benefits in a preclinical model. Further research is warranted to elucidate the underlying mechanisms and evaluate the long-term efficacy and safety of this herbal remedy, bringing us closer to effective and holistic approaches for managing Alzheimer's disease.

Abstract 193 | pdf Downloads 50

References

1. Amini, F., Amini-Khoei, H., Haratizadeh, S., Setayesh, M., Basiri, M., Raeiszadeh, M., & Nozari, M. (2023). Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism. Journal of Traditional and Complementary Medicine, 13(4), 315-324.
2. Avila, J., Jiménez, A., Méndez, J., & Murillo, E. (2021). Chemical and biological potential of passiflora vitifolia fruit byproducts collected in the Colombian central Andes. Asian Journal of Pharmaceutical and Clinical Research, 182-189.
3. Chakraborty, R., & Roy, S. (2021). Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in managing diabetes-centric complications. Journal of Integrative Medicine, 19(6), 478-492.
4. Chen, H., & Li, N. (2021). An Overview of Hypoglycemic Traditional Drugs. Structure and Health Effects of Natural Products on Diabetes Mellitus, 57-80.
5. Coyago-Cruz, E., Guachamin, A., Villacís, M., Rivera, J., Neto, M., Méndez, G., . . . Vera, E. (2023). Evaluation of Bioactive Compounds and Antioxidant Activity in 51 Minor Tropical Fruits of Ecuador. Foods, 12(24), 4439.
6. Czigle, S., Nagy, M., Mladěnka, P., & Tóth, J. (2023). Pharmacokinetic and pharmacodynamic herb-drug interactions—part I. Herbal medicines of the central nervous system. PeerJ, 11, e16149.
7. Das, S., Sahoo, B. M., & Bhattamisra, S. K. (2022). Multifunctional Role of Phytochemicals Derived from Boerhaavia diffusa L. in Human Health, Ailments, and Therapy. Current Nutrition & Food Science, 18(6), 574-588.
8. de Almeida, V. L., Silva, C. G., & Campana, P. R. V. (2021). Flavonoids of Passiflora: isolation, structure elucidation, and biotechnological application. Studies in Natural Products Chemistry, 71, 263-310.
9. Farias, E. F., Pinto, V. G., Lima, E. S., Barcellos, J. F. M., & Lourenço, G. A. (2023). AVALIAÇÃO DO EFEITO NEUROPROTETOR DO TRATAMENTO COM EXTRATO DE PASSIFLORA NITIDA KUNTH EM MODELO EXPERIMENTAL DE DOENÇA DE ALZHEIMER. REVISTA FOCO, 16(6), e2416-e2416.
10. Fragata Farias, E., Gonçalves Pinto, V., Silva Lima, E., Marques Barcellos, J. F., & Antiques Lourenço, G. (2023). AVALIAÇÃO DO EFEITO NEUROPROTETOR DO TRATAMENTO COM EXTRATO DE PASSIFLORA NITIDA KUNTH EM MODELO EXPERIMENTAL DE DOENÇA DE ALZHEIMER. Revista Foco (Interdisciplinary Studies Journal), 16(6).
11. Jiménez-Estrada, M., Huerta-Reyes, M., Tavera-Hernández, R., Alvarado-Sansininea, J. J., & Alvarez, A. B. (2021). Contributions from Mexican flora for treating diabetes mellitus: Molecules of Psacalium decompositum (A. Gray) H. Rob & Brettell. Molecules, 26(10), 2892.
12. Kaikade, A. R., Gurunani, S. G., Pandel, T. W., Sherekar, S. A., Kaikade, P. R., Mehare, S. R., . . . Dhawale, Y. V. (2023). Phyto-Pharmacognostic review on Passiflora species. Journal of Medicinal Plants, 11(3), 35-50.
13. Lucas-González, R., Capanoglu, E., Pateiro, M., Khaneghah, A. M., Hano, C., & Lorenzo, J. M. (2022). Current trends in Passiflora genus research: Obesity and fermented foods systematic review. Trends in Food Science & Technology.
14. Marinov, T., Kokanova-Nedialkova, Z., & Nedialkov, P. T. (2023). Naturally Occurring Simple Oxygenated Benzophenones: Structural Diversity, Distribution, and Biological Properties. Diversity, 15(10), 1030.
15. Miguel-Wruck, D. S., Roncatto, G., Behling, M., Faleiro, V. d. O., Bonaldo, S. M., & Tardin, F. D. (2021). Identification of sources of resistance of Passiflora rootstocks to fusariosis in areas with disease outbreaks in Mato Grosso state, Brazil. Revista Brasileira de Fruticultura, 43.
16. Mostefa, N., Djebli, N., Khanh, P. N., Ha, N. X., Anh, H. T. N., Ha, V. T., . . . Cuong, N. M. (2023). Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and Silico Studies. Chemistry & Biodiversity, 20(5), e202201051.
17. Nikolova, K., Velikova, M., Gentscheva, G., Gerasimova, A., Slavov, P., Harbaliev, N., . . . Gavrilova, A. (2024). Chemical Compositions, Pharmacological Properties and Medicinal Effects of Genus Passiflora L.: A Review. Plants, 13(2), 228.
18. Ożarowski, M., & Karpiński, T. M. (2021). Extracts and flavonoids of Passiflora species as promising anti-inflammatory and antioxidant substances. Current Pharmaceutical Design, 27(22), 2582-2604.
19. Pereira Leal, A. E. B., de Lavor, É. M., de Menezes Barbosa, J., de Moura Fontes Araújo, M. T., dos Santos Cerqueira Alves, C., de Oliveira Jnior, R. G., . . . da Silva Almeida, J. R. (2022). Pharmacological activities of the genus Passiflora (Passifloraceae): a patent review. Current topics in medicinal chemistry, 22(28), 2315-2328.
20. Pereira, Z. C. (2023). Caracterização química de bebidas não alcoólicas à base de maracujá-do-mato (Passiflora nitida).
21. Ribeiro, P. T., Pedrosa, T. d. N., Chaves, F. C. M., José Quintans-Júnior, L., Araújo, A. A. d. S., Vasconcellos, M. C. d., . . . Koolen, H. H. F. (2022). Physicochemical characterization and cosmetic applications of Passiflora nitida Kunth leaf extract. Brazilian Journal of Pharmaceutical Sciences, 58.
22. Shanmugam, S., Rajan, M., de Souza Araújo, A. A., & Narain, N. (2030). Potential of Passion (Passiflora Spp.) Fruit in Control of Type II Diabetes. Diabetes, 3.
23. Sousa, D. F., Veras, V. S., Freire, V. E., Paula, M. L., Serra, M. A., Costa, A. C., . . . Paes, F. E. (2020). Effectiveness of passion fruit peel flour (Passiflora edulis L.) versus turmeric flour (Curcuma longa L.) on glycemic control: systematic review and meta-analysis. Current Diabetes Reviews, 16(5), 450-456.
24. Sun, W., & Shahrajabian, M. H. (2023). Therapeutic potential of phenolic compounds in medicinal plants—Natural health products for human health. Molecules, 28(4), 1845.
25. WRUCK, D., Roncatto, G., Behling, M., FALEIRO, V. d. O., Bonaldo, S. M., & Tardin, F. D. (2021). Identification of sources of resistance of Passiflora rootstocks to fusariosis in areas with disease outbreaks in Mato Grosso state, Brazil.
26. Wu, T., Zhu, W., Chen, L., Jiang, T., Dong, Y., Wang, L., . . . Peng, Y. (2023). A review of natural plant extracts in beverages: Extraction process, nutritional function, and safety evaluation. Food Research International, 113185.
27. Zhang, J., Tao, S., Hou, G., Zhao, F., Meng, Q., & Tan, S. (2023). Phytochemistry, nutritional composition, health benefits and future prospects of Passiflora: A review. Food Chemistry, 136825.

Most read articles by the same author(s)