CORIANDRUM SATIVUM: A NATURAL THERAPEUTIC AGENT FOR NEUROLOGICAL AND PYHSIOLOGICAL DISORDERS
Main Article Content
Keywords
Coriandrum sativum, psychological health, anti-bacterial, non-cytotoxic
Abstract
Background: One of the most important and concerning issues of the world is how to fight the psychological problems everyone is facing every now and then in their personal and professional lives. Multiple studies have been done on various extracts to explore the benefits of a variety of substances in helping psychological wars. However, the most facilitating things were always under the nose and yet unaware of their potential benefits.
Objective: The current study was designed to explore the psychological facilitation characteristics of one of the most commonly used household herbs i.e. Coriandrum sativum. This study focused on evaluating the anti-depressant, anxiolytic as well as anti-bacterial, anti-inflammatory and cytotoxic properties of this herb.
Materials & Methods: 50 rats were used in this study, 250mg/kg and 500mg/kg doses of the test sample were given and the results were evaluated. To evaluate the behavioral outcomes Tail immersion test, Light and dark box test, Elevated T-Maze model tests were used. MTT assay was used for cytotoxic activities and Microplate Alamar Blue Assay (MABA) for anti-microbial activities.
Results: Significant results were obtained in all the tests designed to evaluate psychological and behavioral impact of the test samples. The sample also showed significant inhibition against Bacillus subtilis and low inhibition against Staphylococcus aureus and MTT assay showed non-cytotoxic properties.
Conclusion: Inclusion of Coriandrum sativum in the diet can significantly help in managing not only the psychological but multiple physiological conditions also in a non-cytotoxic manner.
References
2. Bilkei-Gorzo, A., Gyertyan, I., & Levay, G. (1998). mCPP-induced anxiety in the light-dark box in rats–a new method for screening anxiolytic activity. Psychopharmacology, 136(3), 291-298.
3. Blustein, D. L. (2008). The role of work in psychological health and well-being: a conceptual, historical, and public policy perspective. American psychologist, 63(4), 228.
4. Chinmayi, G. A., Renganathan, S., Manjunath, A., & Sabat, S. (2024). Pharmacological Potential of Coriander Seeds: A Dual Action Agent Against LPS of Pseudomonas aeruginosa (ATCC 27853) and an Epidermoid Carcinoma Cell Line. Indian Journal of Microbiology, 1-12.
5. Damásio, B. F., Melo, R. L. P. D., & Silva, J. P. D. (2013). Meaning in life, psychological well-being and quality of life in teachers. Paidéia (Ribeirão Preto), 23, 73-82.
6. Elliott, D. M., & Guy, J. D. (1993). Mental health professionals versus non-mental-health professionals: Childhood trauma and adult functioning. Professional Psychology: Research and Practice, 24(1), 83.
7. Engmann, S. T., & Agede, O. A. (2024). Quality of life and morbidity profile of chronic disease patients treated with herbal medicine in Ghana. Medical Journal of Zambia, 51(3), 268-275.
8. Ferreira, L. C., Batista, L. R., Caetano, A. R. S., Campolina, G. A., Ferreira, V. R. F., Evangelista, S. R., ... & Cardoso, M. D. G. (2024). Antimicrobial, acetylcholinesterase and antioxidant activities of essential oils from allium sativum, coriandrum sativum and anethum graveolens. Australian Journal of Crop Science, 18(11), 707-714.
9. Hajialiasgari, F., Bagheri, K., Anastasio, A., Ghahremani, Z., & Shariat, A. (2025). The role of tele-herbal consultations in workplace wellness. WORK, 10519815251319234.
10. Jovanović, Ž., Pešut, S., & Miletić, B. (2024). Comparison of perception of stress and consumption of anxiolytics in hospital and out-hospital conditions: a cross-sectional study. Frontiers in public health, 12, 1339246.
11. Kolhe, N., Mule, P., Maka, M., Utekar, G., Kadu, D., Pawar, B., & Jadhav, A. (2024). Phytochemical, Pharmacological and Antimicrobial Effects of Coriandrum sativum. African Journal of Biological Sciences, 4496-4508. doi: 10.48047/AFJBS.6.12.2024.4495-4508
12. Liu, C., & Fan, M. (2024). Stock market and the psychological health of investors. Financial Review, 59(3), 561-587.
13. Looi, J. C., Allison, S., Bastiampillai, T., Kisely, S., Maguire, P. A., Woon, L. S., ... & Malhi, G. S. (2024). Deprescribing antidepressants for depression–what is the evidence for and against?. Australasian Psychiatry, 10398562241282377.
14. Martín-Rodríguez, A., Gostian-Ropotin, L. A., Beltrán-Velasco, A. I., Belando-Pedreño, N., Simón, J. A., López-Mora, C., ... & Clemente-Suárez, V. J. (2024). Sporting mind: the interplay of physical activity and psychological health. Sports, 12(1), 37.
15. National Institute of Mental Health. Understanding the link between chronic disease and depression. Accessed online January 14, 2024. https://www.nimh.nih.gov/health/publications/chronic-illness-mental-health.
16. Nouioura, G., El Fadili, M., El Hachlafi, N., Maache, S., Mssillou, I., A. Abuelizz, H., ... & Derwich, E. (2024). Coriandrum sativum L., essential oil as a promising source of bioactive compounds with GC/MS, antioxidant, antimicrobial activities: in vitro and in silico predictions. Frontiers in Chemistry, 12, 1369745.
17. Nouioura, G., El Fadili, M., El Hachlafi, N., Maache, S., Mssillou, I., A. Abuelizz, H., ... & Derwich, E. (2024). Coriandrum sativum L., essential oil as a promising source of bioactive compounds with GC/MS, antioxidant, antimicrobial activities: in vitro and in silico predictions. Frontiers in Chemistry, 12, 1369745.
18. Osahon, P. T., Ogboin, E. E., & Osarenwinda, M. I. (2024). Assessment of the prevalence of depression and the use of antidepressants in a study population. African Journal of Pharmaceutical Research and Development, 16(1), 26-32.
19. Rawat, S., Pandey, P., Joshi, P., Bisht, A., Arya, V., Maiti, P., & Chandra, S. (2024). Exploring the molecular mechanism of anti-inflammatory action of Coriandrum sativum using network pharmacology, molecular dynamic simulation, and density functional theory. Journal of Proteins and Proteomics, 15(3), 449-472.
20. Sewell, R. D. E., & Spencer, P. S. J. (1976). Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats. Neuropharmacology, 15(11), 683-688.
21. Thanapaul, R. J. R. S., Nambur, C. K., & Giriraj, K. (2024). Development of multi-herbal formulation with enhanced antimicrobial, antioxidant, cytotoxic, and antiaging properties. Journal of the Indian Chemical Society, 101(11), 101402.
22. Tolosa, L., Donato, M. T., & Gómez-Lechón, M. J. (2014). General cytotoxicity assessment by means of the MTT assay. In Protocols in in vitro hepatocyte research (pp. 333-348). New York, NY: Springer New York.
23. Vanitha, J. D., & Paramasivan, C. N. (2004). Evaluation of microplate Alamar blue assay for drug susceptibility testing of Mycobacterium avium complex isolates. Diagnostic microbiology and infectious disease, 49(3), 179-182.) (Tyc, O., Tomas-Menor, L., Garbeva, P., Barrajon-Catalan, E., & Micol, V. (2016). Validation of the AlamarBlue® assay as a fast screening method to determine the antimicrobial activity of botanical extracts. PLoS One, 11(12), e0169090.
24. Viana, M. D. B., Tomaz, C., & Graeff, F. G. (1994). The elevated T-maze: a new animal model of anxiety and memory. Pharmacology biochemistry and behavior, 49(3), 549-554.
25. Zaenal, Z., & Mustamin, R. (2024). Perception of Patients Treated with Herbs in Wound Care with Psychological and Emotional Well-Being in Makassar City. Jurnal Aisyah: Jurnal Ilmu Kesehatan, 9(2). Adil, M., Bibi, N., Ilahi, J., Asif, M., Zaman, A., & Jabeen, N. (2025). The Role of Traditional Healing Practices in Pakistani Mental Health: A Psychological Perspective. Journal for Social Science Archives, 3(1), 863-877.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Syeda Hafiza Afsheen Zafar
Department of Pharmacology, Bahria University Health Sciences . Karachi
Syeda Afroz
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical sciences, University of Karachi
Syeda Bushra Zafar
Department of Biomedical Engineering, Faculty of Engineering, Science, Technology & Management Sciences, Ziauddin University
Riffat Farooqui
Department of Pharmacology. Dr. Ishratul Ibad Institute of Oral Health Sciences, Dow University of Health sciences, Karachi
maryum Bano
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical sciences, University of Karachi
Wardha Jawaid
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical sciences, University of Karachi
Ayesha Ismail
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical sciences, University of Karachi