To study the effects of Zinc, omega 3 and Dapagliflozin on lipid profile of diabetic albino rats
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Abstract
Introduction: Diabetes Mellitus (DM) is a chronic condition characterized by chronic hyperglycemia, poly urea, polydipsia and disturbances in primarily in carbohydrate metabolism but also fat and protein metabolism abnormalities been observed Different studies also indicates that omega 3 fatty acids obtained from fish and fish oil are protective against atherosclerosis and ischemic heart disease . In diabetic patient’s hyperlipidemia is one of dangerous feature and leads to IHD. Zinc is required for structural and functional integrity of more than 2000 transcription factors and 300 enzymes; almost all metabolic pathways require zinc.
Material and Method: We took 40 albino rats and made 4 groups Streptozotocin were given to group 2,3, and 4 to produce diabetes and they were kept at high fat diet. Each group contains 10 rats. Group 1 were control group, group 2 Dapagliflozin group. Group 3 was given zinc and group 4 was given omega 3 for 2 months.
Objectives :
To observe the effects of zinc on lipid profile
To observe the effects of Omega 3 on lipid profile
Results: At the end of study all data were analyzed by SPSS vision 20. Zinc and omega 3 showed beneficial effects on dyslipidemia, they reduce total cholesterol and triglyceride and on the other hand slightly decreases level of LDL.
Conclusion: Omega 3 and zinc can be used in diabetic and patients with ischemic heart disease for dyslipidemia.
References
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Mohammad Sair
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi ,
Syeda Afroz
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi ,
Shahnaz Usman
Professor, Department of Pharmaceutics, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ra's Al khaimah, UAE
Sana Imran
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi ,
Sumaira Khadim
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi ,
Nabeela Sikander
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi ,