ASSOCIATION OF SERUM ALBUMIN LEVELS WITH AFP AND PIVA-II IN PATIENTS WITH HEPATOCELLULAR CARCINOMA
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Keywords
Hepatocellular Carcinoma, AFP, PIVKA-II, Albumin, Prognosis
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors affecting the digestive tract, ranking fifth in morbidity and third in mortality among cancers globally, posing a severe threat to health and life. This study investigated whether serum albumin levels are associated with alpha-fetoprotein (AFP) and PIVKA-II in HCC patients. Conducted as an experimental study in the medical laboratory of Islamabad Diagnostic Center, Faisalabad, it involved the planned recruitment of 50 participants who provided written consent prior to sample collection. Patients were evaluated based on serum AFP, PIVKA-II, and other laboratory parameters. The findings from univariate logistic regression analysis revealed that the HCC group had significantly higher concentrations of AFP and PIVKA-II (p < 0.01). Additionally, a decrease in albumin levels (p = 0.056) was observed with increasing levels of AFP and PIVKA-II. The study concluded that there is a significant negative correlation between albumin levels and the levels of PIVKA-II and AFP in HCC patients, suggesting that lower albumin levels may indicate more severe liver disease and advanced disease progression. Furthermore, a positive correlation between AFP and PIVKA-II levels supports their combined use for diagnostic or therapeutic purposes.
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Muhammad Talha Asif
Faculty of Rehabilitation & Allied Health Sciences, Riphah International University, Islamabad
Shahzadi Javeed
Department of Biology, University of Okara
Tayyab Khurshid
Department of Pathology, University of Veterinary and Animal Sciences, Lahore.
Sadia Ahmed Zuberi
Faculty of Pharmacy, Salim Habib University, Karachi
Qandeel Abbas Soomro
Assistant professor of pathology, Indus Medical College Tando Muhammad Khan, Sindh
Amirullah
Department of Pharmacy, Abbottabad University of Science and Technology, Abbottabad
Qambar Abbas
Faculty of Biological, Pharmaceutical and Health Sciences, University of Balochistan
Muhammad Rizwan
Allied Health professional, Government College University Faisalabad
Haseeb Khaliq
Department of Anatomy and Histology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur