Therapeutic Potential of Cherry Phenolics in Managing Inflammation and Lipid Metabolism in Diabetes and Obesity
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Keywords
Cherries, Diabetes, inflammation, lipid metabolism, non-anthocyanin phenolics, obesity
Abstract
This study investigates the potential therapeutic effects of non-anthocyanin phenolics derived from cherries (Prunus avium L.) in addressing inflammatory and metabolic disturbances associated with diabetes and obesity. Using a diabetic obese mouse model, the study explores the impact of cherry phenolics on inflammatory cytokines, liver lipid profiles, and gene expression related to inflammation and lipid metabolism. The results demonstrate significant reductions in serum inflammatory cytokines, liver triglycerides, total cholesterol, and non-esterified fatty acids, accompanied by downregulating critical genes involved in inflammation and lipogenesis. These findings suggest that cherry phenolics possess antiinflammatory and lipid-lowering properties, highlighting their potential as therapeutic agents for managing diabetes and obesity-related complications.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Tausif Ahmad
PhD Scholar, Department of Agricultural Engineering and Food Sciences, Shandong University of Science and Technology, China
Aaima Farooq
Dietitian and Nutritionist, Job Leading Nutrition Department, Chaudhary Muhammad Akram Teaching and Research Hospital, Lahore, Pakistan
Sehrish Kanwal
Master Student, Karakoram International University, Pakistan
Shaheer Khan
Bachelor Student, University of Lahore, Lahore, Pakistan
Wania Adan
MPhil Scholar, University of Lahore, Lahore, Pakistan
Rida Maqsood
MPhil Scholar, University of Lahore, Lahore, Pakistan
Smeea Fatima
Lecturer, Rashid Latif Khan University, Lahore, Pakistan
Areeba Sanaullah
Lecturer, ARID University, Burewala Campus, Pakistan