“SYNERGISTIC EFFECTS OF ZINC AND CHOLINE FROM DIETARY SOURCES ON ALLEVIATING EXPERIMENTAL POLYCYSTIC OVARIAN SYNDROME IN RAT MODELS”
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Keywords
Animal Models, Choline, Dietary Sources, Hormonal Regulation, Ovarian Health, Polycystic Ovarian Syndrome (PCOS), Reproductive Health, Zinc
Abstract
This study investigates the synergistic effects of zinc and choline on PCOS. PCOS is a complex endocrine disorder with reproductive and metabolic implications. Different dietary interventions were administered through sources including eggs, almonds, poppy seeds, and sesame seeds to female Wistar albino rats, induced with PCOS. Forty-five rats were randomly divided into five groups and were given with iso-caloric and iso-nitrogenous diet. Those, without induced PCOS and basal diet were under NC, with induced PCOS and basal diet under in PC and remaining were under three treatment groups named ZC1, ZC2, and ZC3; Induced PCOS and tested diets with varying zinc and choline concentrations, as per Recommended Dietary Allowances (RDA). Daily water and feed intake, weekly weight changes, total collection methods and blood samples were used to determine results. The ZC1 treatment group, adhering to RDA for zinc and choline, demonstrated significant decrease (p<0.05) in estrogen, progesterone, LH, FSH, TG, TC, LDL, insulin and weight. Low levels of testosterone were found in group ZC3 and mature follicular count increased with fewer cyst compared to the PC group. Research findings concludes the potential of zinc and choline synergist effect in alleviating hormonal imbalances, insulin resistance, lipid abnormalities, and nutrient digestibility in PCOS induced female Wistar albino rats offering insights into dietary interventions for PCOS management.
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Samra Faisal
Samra Faisal, Department of Human Nutrition and Dietetics, Riphah International University, Islamabad, Pakistan
Tabeen Irfan
Department of Human Nutrition and Food Technology, Faculty of Allied Health Sciences, Superior University Lahore, Pakistan
Noor ul ain Shah
Department of Human Nutrition and Food Technology, Faculty of Allied Health Sciences, Superior University Lahore, Pakistan
Mahnoor Naseer Ahmed
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Saad Shafi
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Smeea Fatima
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Rimsha Sattar
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Safa Sahar
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan