EFFECT OF Β - SITOSTEROL SUPPLEMENT ALONG WITH FAT MODIFIED DIET FOR THE MANAGEMENT OF DYSLIPIDEMIA
Main Article Content
Keywords
β – Sitosterol, Cholesterol, Dyslipidemia, Fat Modified Diet, Lipoproteins, Phytosterol, Supplement
Abstract
β – Sitosterol supplements have been one of the important Phytosterols. β – Sitosterol is used to lower the cholesterol in the blood which leads to a decrease in the risk of cardiovascular diseases. It is also recognized to lower the incidence of dyslipidemia. Objective of the study was to evaluate the effect of β- sitosterol supplement along with fat modified diet for the management of dyslipidemia. Randomized control trial was conducted. Total of 36 participants successfully completed the trial. Targeted population was patients suffering from dyslipidemia aged 35 to 55 years. All enrolled participants were allocated randomly in 2 groups. Treatment group (T1) was allocated to consume 900 mg beta-sitosterol supplement twice a day along with the fat-modified diet plan. The fat-modified diet plan was containing 1500 – 1600 kcal per day, with AMDR for carbohydrates 202.5 g, Protein 67.5 g, and fats 46.7 g. In the fat group, mostly MUFAs and PUFAs were prescribed. The control group was on a regular basal diet. Duration of study trial was 6 weeks. The results indicate significant difference between the pre and post-interventional treatment group (T1). In the treatment group, post-interventional serum total cholesterol, triglycerides, LDL and HDL are 140.55 ± 35.17 mg/dl (p ≤ 0.002), 137.22 ± 36.86 mg/dl (p ≤ 0.00001), 41.72 ± 7.39 mg/dl (p ≤ 0.0001) and 107.22 ± 23.74 mg/dl (p ≤ 0.00002) respectively. Furthermore, the treatment group also showed a significant difference if compared with the control group. Independent sample t-test shows p-value of serum total cholesterol (p ≤ 0.00007), triglycerides (p ≤ 0.014), and LDL (p ≤ 0.04) show significant change. The findings of the current study support the cholesterol-lowering effect of β- sitosterol supplements along with fat modified diet. It is also concluded that the intake of β - sitosterol supplements along with fat modified diet is helpful for the management of dyslipidemia and also lowers the risk of cardiovascular diseases. It is concluded that the current research study shows significantly positive results and supports our alternate hypothesis. It is suggested that the β – Sitosterol should be fortified in the food products to prevent and treat dyslipidemia. In diet-based therapies, beta-sitosterol supplements or beta-sitosterol-enriched food products should be recommended to treat various ailments.
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Smeea Fatima
Department of Nutrition & Dietetics, University of Management and Technology, Lahore, Pakistan
Momina Shahid
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Mahnoor Naseer Ahmed
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Saad Shafi
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Sadia Sabir
Department of Human Nutrition and Food Technology, Faculty of Allied Health Sciences, Superior University Lahore, Pakistan
Noor Ul Ain Shah
Department of Human Nutrition and Food Technology, Faculty of Allied Health Sciences, Superior University Lahore, Pakistan
Wajiha Arooj
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan
Ribka Sabahat
University Institute of Diet & Nutritional Sciences, The University of Lahore, Pakistan