COMPARISON OF CLINICAL OUTCOME OF AUTOINOCULATION VS ACITRETIN IN PATIENTS WITH VIRAL WARTS AT TERTIARY CARE HOSPITAL, KARACHI
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Keywords
Viral Warts, Autoinoculation, Acitretin, clinical outcomes
Abstract
Background: Viral warts are benign growths on the skin, mucous membranes, and other epithelial tissues caused by various strains of the human papillomavirus (HPV). Autoinoculation and acitretin have shown efficacy in treating multiple viral warts by increasing the immune response and reducing wart’s proliferation. Autoinoculation stimulates the body's defense mechanisms whereas Acitretin acts as a systemic retinoid to promote skin regeneration and reduce wart recurrence.
Objective: The present study aimed to compare the clinical outcome of autoinoculation vs acitretin in viral warts patients, at tertiary care hospital, Karachi.
Study Design: Randomized controlled trial
Materials and Methods: This randomized controlled trial investigated 40 viral warts patients in the Dermatology Department of Tertiary Care Hospital, Karachi from March 2024 to August 2024. Eligible participants were randomly assigned to one of the two treatment groups: Group A (Autoinoculation therapy; n =20) and Group B (Acitretin therapy; n=20). Patients in Group A (Autoinoculation therapy) were received autoinoculation therapy. Group B patients administrated with Oral acitretin 0.5 mg/kg body weight/day for a total duration of three months. Efficacy of Autoinoculation and Acitretin therapy measured in terms of complete, partial, and no response. SPSS version 23 was used for data analysis.
Results: Mean age of patients was 27.25 ± 10.32 years. The mean duration of warts disease was 8.78 ± 6.24 months. Cosmetic disfigurement, Itching, and Pain was the most prevalent symptoms of warts. Among 40 warts cases, the common warts were the prevalent type of warts found in 29 (72.5%) followed by Plantar 8 (20%) and plane 3 (7.5%). Regarding the site of wart, hand was the most common site 21 (52.5%) followed by feet 14 (35%). The incidence of complete, partial, and no response in Group A vs. Group B was 5 (25%) vs. 3 (15%), 13 (65%) vs. 11 (55%), and 2 (10%) vs. 6 (30%), respectively. There was no statistical significance regarding side effects in both groups.
Conclusions: This study shows that autoinoculation is a promising treatment for viral warts, resulting in better clinical outcomes and patient satisfaction compared to acitretin. Autoinoculation is considered as one of the effective and safe treatment of viral warts.
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Muhammad Khurram
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Rabia Ghafoor
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Misbah Zari Qadir
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Kanwal Phulpoto
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Soonha Iqra
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Nazia Jabeen
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Ashraf Hussain
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan
Khadija Asadullah
Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi Pakistan