COMPARISON OF THE EFFECTS OF INTRALESIONAL TRIAMCINOLONE ACETONIDE TREATMENT WITH INTRALESIONAL VERAPAMIL HYDROCHLORIDE IN PATIENTS PRESENTING WITH SCAR
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Keywords
Intralesional triamcinolone acetonide, intralesional verapamil hydrochloride and scar.
Abstract
Keloid is an abnormal fibrous tissue development extend beyond the incision. Intralesional triamcinolone acetonide is the most used keloids corticosteroid. Intralesional verapamil is new. Both medications were compared to help us choose the best keloids treatment.
OBJECTIVE: To compare the effects of intralesional triamcinolone acetonide treatment with intralesional verapamil hydrochloride in patients presenting with scar at Jinnah Hospital, Karachi.
METHODS: This Randomized was held in the Department of Dermatology, JPMC, Karachi for Six months after approval from 03 July, 2021 till 03 January 2022. Data was prospectively collected from patients after taking a verbal consent. 100 patients who met the diagnostic criteria were included. Quantitative and qualitative data was collected, presented and analyzed. Post stratification chi square test was applied taking p-value of ≤0.05 as significant.
RESULTS: A total of 124 patients who met the inclusion and exclusion criteria were included in this study. Mean age and duration of scar in our study was 48.21±6.24 years and 14.54±9.78 months in the intralesional triamcinolone acetonide group. Mean age and duration of scar in our study was 49.48±8.41 years and 14.97±9.56 months in the intralesional triamcinolone acetonide group.
CONCLUSION: Both triamcinolone and verapamil intralesional injections can achieve scar flattening in hypertrophic scars and keloids. Intralesional triamcinolone continues to be the gold standard for the first line treatment owing to its rapid and effective response.
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Hadia Akram
MBBS, FCPS, Consultant dermatologist, Department of Dermatology, Anam Hospital, Karachi -Pakistan
Rabia Ghafoor
MBBS, FCPS, SCE Derm (UK), Assistant Professor, Consultant Dermatologist, Jinnah Postgraduate Medical Centre Karachi - Pakistan
Ramla Moughal
MBBS, FCPS, Consultant Dermatologist, Jinnah Postgraduate Medical Centre Karachi -Pakistan
Maria Naseer
MBBS, FCPS, Assistant Professor Department of Dermatology, People’s University of Medical Health and Sciences Women Shaheed Benazirabad - Pakistan
Alina Ahmed
Consultant Dermatologist, Department of Dermatology, Dr. Ruth K M Pfau Civil Hospital, Karachi - Pakistan
Vinesha Devi
MBBS,FCPS, Consultant Dermatologist, Department of Dermatology, Dr. Ruth K.M Pfau Civil Hospital, Dow University of Health Sciences, Karachi - Pakistan