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Intralesional triamcinolone acetonide, intralesional verapamil hydrochloride and scar.
Keloid is an abnormal fibrous tissue development extend beyond the incision. Intralesional triamcinolone acetonide is the most used keloids corticosteroid. Intralesional verapamil is new. Both medications were compared to help us choose the best keloids treatment.
OBJECTIVE: To compare the effects of intralesional triamcinolone acetonide treatment with intralesional verapamil hydrochloride in patients presenting with scar at Jinnah Hospital, Karachi.
METHODS: This Randomized was held in the Department of Dermatology, JPMC, Karachi for Six months after approval from 03 July, 2021 till 03 January 2022. Data was prospectively collected from patients after taking a verbal consent. 100 patients who met the diagnostic criteria were included. Quantitative and qualitative data was collected, presented and analyzed. Post stratification chi square test was applied taking p-value of ≤0.05 as significant.
RESULTS: A total of 124 patients who met the inclusion and exclusion criteria were included in this study. Mean age and duration of scar in our study was 48.21±6.24 years and 14.54±9.78 months in the intralesional triamcinolone acetonide group. Mean age and duration of scar in our study was 49.48±8.41 years and 14.97±9.56 months in the intralesional triamcinolone acetonide group.
CONCLUSION: Both triamcinolone and verapamil intralesional injections can achieve scar flattening in hypertrophic scars and keloids. Intralesional triamcinolone continues to be the gold standard for the first line treatment owing to its rapid and effective response.
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