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Nazia Jabeen
Rabia Ghafoor
Parisa Sanawar
Khadija Asadullah
Misbah Qadir
Muhammad Khurram Salahuddin


Acne vulgaris, Micro-needling, Platelet Rich Plasma, Insulin, Post-acne atrophic scar


Objective: To compare the outcome of treatment of microneedling with autologous platelet-rich plasma versus microneedling with topical insulin in the treatment of postacne atrophic scars at Tertiary Care Hospital, Karachi.

Study design:Randomized controlled trial.

Place and duration of study: This study was conducted at Department of Dermatology, JPMC, Karachi from August 2022 to January 2023.

Material and methods: Total 50 patients were selected. After taking proper consent, post acne scars patient were included in this study, 25 patients in each group. Random allocation was determined through sealed opaque envelopes labeled as MP (Microneedling with autologous platelet-rich plasma group) and MI (Microneedling with topical insulin group). Data was analysed on SPSS (version 23.0).

Results: The study included participants aged 20 to 50 years, with a mean age of 34.51±10.78 years in Group MI and 35.36±9.78 years in Group MP. Predominantly, patients in both groups were within the 20-35 years age range, and the majority were male. Posttreatment, the SQGS grade distribution indicated that patients in Group MI achieved grades 0, 1, 2, 3, and 4 in 4%, 4%, 8%, 24%, and 60%, respectively, compared to Group MP which achieved 4%, 12%, 28%, 36%, and 20%, respectively.

Conclusion: It can be concluded from this study that microneedling with insulin can improve postacne atrophic scars treatment and is a superior option to microneedling with PRP.

Abstract 309 | pdf Downloads 159


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