DESIGN, DEVELOPMENT AND CHARACTERIZATION OF CIPROFLOXACIN BASED FLOATING DRUG DELIVERY SYSTEM
Main Article Content
Keywords
Ciprofloxacin, swelling index, direct compression, floating lag time, in-vitro drug release
Abstract
Ciprofloxacin is associated with reduced bioavailability due to dissolution and absorption from upper part of GIT. Controlled release technology covers frequency of administration, but reduced bioavailability demands increased gastric residence time. So, floating drug delivery systems represent an ideal drug delivery mode to increase gastric residence time leading to improved bioavailability. This study aimed to formulate polymeric floating tablets of ciprofloxacin for oral drug delivery. Direct compression method was employed for the preparation of tablets using different polymers like HPMC, alginate and chitosan. Physicochemical evaluation tests were performed on all the prepared tablets. 0.1 N HCl solution was used for floating, swelling and in-vitro release studies. The drug, polymers and excipients had no incompatibilities as confirmed by FTIR results. Total floating time of all the formulated tablets was higher than 12 h with maximum swelling index exhibited by F6. In-vitro studies depicted that combination of polymers can sustain the release of drug in better way and followed anomalous non-Fickian diffusion mechanism. Similarly, the optimized ciprofloxacin floating tablets were investigated for effect of pH, agitational intensity and osmotic pressure. The results confirmed that ciprofloxacin loaded floating drug delivery system produced promising results to enhance bioavailability.
References
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6. Alalor CA, Uhumwangho MU, Iwuagwu MA. Evaluation of Ciprofloxacin Floating-Bioadhesive Tablet Formulated with Okra Gum as Multifunctional Polymer. UK J Pharm Biosci. 2018;6(2):1–11.
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8. Ahirrao S, Bhambere D, Todkar K, Patil M, Khairnar P, Udavan P, et al. Formulation Development and Evaluation of Floating Tablets of Zolmitriptan. Biosci Biotechnol Res Asia. 2022 Jun 30;19(2):395–405.
9. Rahamathulla M, Hani U, Pharm Sci PJ, Alam N, Ibrahim Q, Alhamhoom Y. Development and in vitro evaluation of effervescent floating matrix tablet of neritinib: An anticancer drug. Pak J Pharm Sci [Internet]. 2021 [cited 2023 Feb 3];34(4):1297–303. Available from: https://www.researchgate.net/publication/356422761
10. Naseem F, Shah SU, Rashid SA, Farid A, Almehmadi M, Alghamdi S. Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of H. pylori: Preparation and In Vitro Characterization. Polymers (Basel) [Internet]. 2022 Jan 27 [cited 2022 Jan 28];14(3):519. Available from: https://www.mdpi.com/2073-4360/14/3/519/htm
11. Maddiboyina B, Hanumanaik M, Nakkala RK, Jhawat V, Rawat P, Alam A, et al. Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension. Heliyon. 2020 Nov 1;6(11):e05459.
12. Eswaraiah M, Jaya S. Design and in Vitro Characterization of Floating Tablets of Metronidazole. Asian J Pharm Clin Res. 2019;12(3):539–44.
13. Khan J, Kusmahani SH, Ruhi S, Al-Dhalli S, Kaleemullah M, Saad R, et al. Design and evaluation of sustained release matrix tablet of flurbiprofen by using hydrophilic polymer and natural gum. Int J Med Toxicol Leg Med. 2020 Jan 1;23(1–2):149–59.
14. Rashid R, Zaman M, Ahmad M, Khan MA, Butt MH, Salawi A, et al. Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations. Pharmaceuticals [Internet]. 2022 Mar 8 [cited 2023 Mar 12];15(3):326. Available from: https://www.mdpi.com/1424-8247/15/3/326/htm
15. Balkrishana VY, Ajinath SH, Singh KH, Gokul TS, Govindrao JA, Balkrishana VY. Formulation and evaluation of gastro retentive extended release formulation of metformin hydrochloride. GSC Adv Res Rev [Internet]. 2020 Feb 28 [cited 2023 Feb 3];2(2):008–17. Available from: https://gsconlinepress.com/journals/gscarr/content/formulation-and-evaluation-gastro-retentive-extended-release-formulation-metformin
16. Gawai N, Zaheer Z. Formulation and evaluation of 5-fluorouracil buccal mucoadhesive buccal tablet. J Pharmacogn Phytochem [Internet]. 2018 Sep 1 [cited 2023 Jun 21];7(6S):19–23. Available from: https://www.phytojournal.com/special-issue/2018.v7.i6S.6616/formulation-and-evaluation-of-5-fluorouracil-buccal-mucoadhesive-buccal-tablet
17. Koirala S, Nepal P, Ghimire G, Basnet R, Rawat I, Dahal A. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac. Heliyon [Internet]. 2021 Mar 1 [cited 2023 Apr 11];7(3):e06439. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2405844021005442
18. Pandey NK, Ghatuary SK, Dubey A, Jain PK. Formulation and In Vitro Evaluation of Sustained Release Floating Matrix Tablet of Levofloxacin by Direct Compression Method. J Drug Deliv Ther [Internet]. 2019 Aug 15 [cited 2023 Aug 10];9(4-s):398–403. Available from: https://jddtonline.info/index.php/jddt/article/view/3345
19. Djebbar M, Chaffai N, Bouchal F. Development of Floating Tablets of Metformin HCl by Thermoplastic Granulation. Part II: In Vitro Evaluation of the Combined Effect of Acacia Gum/HPMC on Biopharmaceutical Performances. Adv Pharm Bull [Internet]. 2020 [cited 2023 Feb 3];10(3):399. Available from: /pmc/articles/PMC7335996/
20. López KJS, Vásquez SLG, Vásquez YAG, Suárez AIT, Barranco PG, Gutiérrez MLY, et al. Formulation and evaluation of gastroretentive floating tablets of metformin hydrochloride based on effervescence and swelling. Farma J. 2019;4(1):305.
21. Sheikh FA, Hussain MA, Ashraf MU, Haseeb MT, Farid-ul-Haq M. Linseed hydrogel based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection. Saudi Pharm J. 2020 May 1;28(5):538–49.
22. Teaima M, Hamid MMA, Shoman NA, Jasti BR, El-Nabarawi MA. Promising swellable floating bupropion tablets: Formulation, in vitro/in vivo evaluation and comparative pharmacokinetic study in human volunteers. Drug Des Devel Ther [Internet]. 2020 Jul 1 [cited 2023 Feb 3];14:2741–57. Available from: http://doi.org/10.2147/DDDT.S258571
23. Gundu R, Pekamwar S, Shelke S, Shep S, Kulkarni D. Sustained release formulation of Ondansetron HCl using osmotic drug delivery approach. Drug Dev Ind Pharm [Internet]. 2020 Mar 3 [cited 2024 Jun 23];46(3):343–55. Available from: https://www.tandfonline.com/doi/abs/10.1080/03639045.2020.1716372
24. Labot JM, Manzo RH, Allemandi DA. Double-layered mucoadhesive tablets containing nystatin. AAPS PharmSciTech [Internet]. 2002 [cited 2021 Apr 7];3(3):1–6. Available from: https://pubmed.ncbi.nlm.nih.gov/12916937/
25. Singh K, Mishra A, Singh A. Synthesis Characterization and In Vitro Release Study of Ciprofloxacin-Loaded Chitosan Nanoparticle. Bionanoscience [Internet]. 2018 Mar 1 [cited 2024 Jun 23];8(1):229–36. Available from: https://link.springer.com/article/10.1007/s12668-017-0470-7
26. Jatav R, Singh D, Rathore P, Prakash Jain N, Goswami RB, Jatav Students of MPharm R. FORMULATION AND EVALUATION OF FLOATING PELLETS OF AMOXICILLIN TRIHYDRATE FOR ERADICATION OF H.PYLORI. World J Pharm Res [Internet]. 2021 [cited 2023 Feb 14];10(9):1024–47. Available from: www.wjpr.net
27. Dumpa NR, Bandari S, Repka MA. Novel gastroretentive floating pulsatile drug delivery system produced via hot-melt extrusion and fused deposition modeling 3D printing. Pharmaceutics [Internet]. 2020 Jan 8 [cited 2021 Apr 6];12(1). Available from: /pmc/articles/PMC7023033/
28. Raza A, Bukhari NI, Karim S, Hafiz MA, Hayat U. Floating tablets of minocycline hydrochloride: Formulation, in-vitro evaluation and optimization. Futur J Pharm Sci. 2017 Dec 1;3(2):131–9.
29. Iglesias N, Galbis E, Romero-Azogil L, Benito E, Lucas R, García-Martín MG, et al. In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations. Pharmaceutics [Internet]. 2020 Jul 7 [cited 2023 Feb 10];12(7):636. Available from: https://www.mdpi.com/1999-4923/12/7/636/htm
30. Noreen M, Farooq MA, Ghayas S, Bushra R, Yaqoob N, Abrar MA. Formulation and in vitro characterization of sustained release tablets of lornoxicam. Lat Am J Pharm. 2019;38(4):701–11.
31. Manogna K, Nagaveni P, Thyagaraju K. A Review On Mucoadhesive Bilayer Buccal Tablets. Am J PharmTech Res. 2018;8(1):101–15.
32. Patel MB, Shaikh F, Patel V, Surti NI. Application of simplex centroid design in formulation and optimization of floating matrix tablets of metformin. J Appl Pharm Sci [Internet]. 2017 [cited 2023 Feb 3];7(04):23–030. Available from: http://www.japsonline.com
33. Huh HW, Na YG, Kang HC, Kim M, Han M, Pham TMA, et al. Novel self-floating tablet for enhanced oral bioavailability of metformin based on cellulose. Int J Pharm. 2021 Jan 5;592:120113.
34. Kumar SA, Debnath M, Anusha K, Manna K, Rao JS. Studies on Formulation Development and Evaluations on Losartan Floating and Bioadhesive Drug Delivery System. Pakistan J Pharm Res. 2017;3(2):84–98.
35. Nigusse B, Gebre-Mariam T, Belete A. Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride. PLoS One [Internet]. 2021 Jun 1 [cited 2023 Feb 14];16(6):e0253391. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253391
36. Varshi R, Jain V, Pal P. A review on Advanced approaches and polymers used in gastroretentive drug delivery systems. J Drug Deliv Ther [Internet]. 2022 Jul 15 [cited 2023 Feb 10];12(4):181–5. Available from: http://www.jddtonline.info/index.php/jddt/article/view/5422/4793
37. Bhatt P, Patel D, Patel A, Patel A, Nagarsheth A. Oral Controlled Release Systems: Current Strategies and Challenges. In: Novel Drug Delivery Technologies: Innovative Strategies for Drug Re-positioning [Internet]. Springer, Singapore; 2019 [cited 2024 Jun 23]. p. 73–120. Available from: https://link.springer.com/chapter/10.1007/978-981-13-3642-3_4
38. Iqbal DN, Tariq M, Khan SM, Gull N, Sagar Iqbal S, Aziz A, et al. Synthesis and characterization of chitosan and guar gum based ternary blends with polyvinyl alcohol. Int J Biol Macromol. 2020 Jan 15;143:546–54.
39. Vega MAC, Deng M, Pinal R. Modular solid dosage form design – Application to pH-independent release of a weak-base API. Int J Pharm. 2021 May 15;601:120518.
40. Gull N, Khan SM, Zahid Butt MT, Khalid S, Shafiq M, Islam A, et al. In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study. RSC Adv [Internet]. 2019 Oct 1 [cited 2024 Jun 23];9(53):31078–91. Available from: https://pubs.rsc.org/en/content/articlehtml/2019/ra/c9ra05025f
41. Huang J, Lin H, Peng B, Huang Q, Shuai F, Xie Y. Design and Evaluation of Hydrophilic Matrix System for pH-Independent Sustained Release of Weakly Acidic Poorly Soluble Drug. AAPS PharmSciTech [Internet]. 2018 Jul 1 [cited 2023 Mar 12];19(5):2144–54. Available from: https://link.springer.com/article/10.1208/s12249-018-1008-1
42. Swain RP, Nagamani A, Shankar PU. Formulation and Evaluation of Gastro-bilayer Floating Tablets of Ezetimibe as Immediate Release Layer and Atenolol as Sustained Release Layer. Indian J Pharm Educ Res | [Internet]. 2019 [cited 2023 Jun 21];53(2):S93–103. Available from: www.ijper.org
43. Kumari B, Pandey P, Dureja H. Formulation and Characterization of Gastroretentive Floating Tablets of Atorvastatin Calcium Using Central Composite Design. J Pharm Res [Internet]. 2017 Sep 1 [cited 2021 Apr 4];16(3):247. Available from: http://www.journalofpharmaceuticalresearch.org/index.php/kpc/article/view/118782
44. Ovenseri AC, Uhumwangho UM, Obarisiagbon AJ, Umechukwu CP. Formulation of non-effervescent floating matrix tablets of metronidazole using Abelmoschus esculentus gum as binder and 2-camphanone as sublimating agent. J Phytomedicine Ther. 2020;19(1).
2. Alam A, Hasan Khan M, Kumar H, Ranjan Swain S. DESIGN AND IN VITRO AND IN VIVO EVALUATION OF FLOATING MICROSPHERES OF METFORMIN HYDROCHLORIDE FOR ORAL CONTROLLED RELEASE. World J Pharm Res [Internet]. 2021 [cited 2023 Feb 3];10(5):1499–510. Available from: www.wjpr.net
3. Vinarov Z, Abdallah M, Agundez JAG, Allegaert K, Basit AW, Braeckmans M. Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. Eur J Pharm Sci. 2021 Jul 1;162:105812.
4. Hua S. Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors. Front Pharmacol. 2020 Apr 28;11:1–22.
5. Almeleebia TM, Akhter MH, Khalilullah H, Rahman MA, Ahmad S, Alam N, et al. Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity. ACS Omega [Internet]. 2024 [cited 2024 Feb 23];9(6):6845–60. Available from: https://pubs.acs.org/doi/full/10.1021/acsomega.3c08200
6. Alalor CA, Uhumwangho MU, Iwuagwu MA. Evaluation of Ciprofloxacin Floating-Bioadhesive Tablet Formulated with Okra Gum as Multifunctional Polymer. UK J Pharm Biosci. 2018;6(2):1–11.
7. Arshad R, Tabish TA, Kiani MH, Ibrahim IM, Shahnaz G, Rahdar A, et al. A hyaluronic acid functionalized self-nano-emulsifying drug delivery system (Snedds) for enhancement in ciprofloxacin targeted delivery against intracellular infection. Nanomaterials [Internet]. 2021 May 1 [cited 2024 Feb 20];11(5):1086. Available from: https://www.mdpi.com/2079-4991/11/5/1086/htm
8. Ahirrao S, Bhambere D, Todkar K, Patil M, Khairnar P, Udavan P, et al. Formulation Development and Evaluation of Floating Tablets of Zolmitriptan. Biosci Biotechnol Res Asia. 2022 Jun 30;19(2):395–405.
9. Rahamathulla M, Hani U, Pharm Sci PJ, Alam N, Ibrahim Q, Alhamhoom Y. Development and in vitro evaluation of effervescent floating matrix tablet of neritinib: An anticancer drug. Pak J Pharm Sci [Internet]. 2021 [cited 2023 Feb 3];34(4):1297–303. Available from: https://www.researchgate.net/publication/356422761
10. Naseem F, Shah SU, Rashid SA, Farid A, Almehmadi M, Alghamdi S. Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of H. pylori: Preparation and In Vitro Characterization. Polymers (Basel) [Internet]. 2022 Jan 27 [cited 2022 Jan 28];14(3):519. Available from: https://www.mdpi.com/2073-4360/14/3/519/htm
11. Maddiboyina B, Hanumanaik M, Nakkala RK, Jhawat V, Rawat P, Alam A, et al. Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension. Heliyon. 2020 Nov 1;6(11):e05459.
12. Eswaraiah M, Jaya S. Design and in Vitro Characterization of Floating Tablets of Metronidazole. Asian J Pharm Clin Res. 2019;12(3):539–44.
13. Khan J, Kusmahani SH, Ruhi S, Al-Dhalli S, Kaleemullah M, Saad R, et al. Design and evaluation of sustained release matrix tablet of flurbiprofen by using hydrophilic polymer and natural gum. Int J Med Toxicol Leg Med. 2020 Jan 1;23(1–2):149–59.
14. Rashid R, Zaman M, Ahmad M, Khan MA, Butt MH, Salawi A, et al. Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations. Pharmaceuticals [Internet]. 2022 Mar 8 [cited 2023 Mar 12];15(3):326. Available from: https://www.mdpi.com/1424-8247/15/3/326/htm
15. Balkrishana VY, Ajinath SH, Singh KH, Gokul TS, Govindrao JA, Balkrishana VY. Formulation and evaluation of gastro retentive extended release formulation of metformin hydrochloride. GSC Adv Res Rev [Internet]. 2020 Feb 28 [cited 2023 Feb 3];2(2):008–17. Available from: https://gsconlinepress.com/journals/gscarr/content/formulation-and-evaluation-gastro-retentive-extended-release-formulation-metformin
16. Gawai N, Zaheer Z. Formulation and evaluation of 5-fluorouracil buccal mucoadhesive buccal tablet. J Pharmacogn Phytochem [Internet]. 2018 Sep 1 [cited 2023 Jun 21];7(6S):19–23. Available from: https://www.phytojournal.com/special-issue/2018.v7.i6S.6616/formulation-and-evaluation-of-5-fluorouracil-buccal-mucoadhesive-buccal-tablet
17. Koirala S, Nepal P, Ghimire G, Basnet R, Rawat I, Dahal A. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac. Heliyon [Internet]. 2021 Mar 1 [cited 2023 Apr 11];7(3):e06439. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2405844021005442
18. Pandey NK, Ghatuary SK, Dubey A, Jain PK. Formulation and In Vitro Evaluation of Sustained Release Floating Matrix Tablet of Levofloxacin by Direct Compression Method. J Drug Deliv Ther [Internet]. 2019 Aug 15 [cited 2023 Aug 10];9(4-s):398–403. Available from: https://jddtonline.info/index.php/jddt/article/view/3345
19. Djebbar M, Chaffai N, Bouchal F. Development of Floating Tablets of Metformin HCl by Thermoplastic Granulation. Part II: In Vitro Evaluation of the Combined Effect of Acacia Gum/HPMC on Biopharmaceutical Performances. Adv Pharm Bull [Internet]. 2020 [cited 2023 Feb 3];10(3):399. Available from: /pmc/articles/PMC7335996/
20. López KJS, Vásquez SLG, Vásquez YAG, Suárez AIT, Barranco PG, Gutiérrez MLY, et al. Formulation and evaluation of gastroretentive floating tablets of metformin hydrochloride based on effervescence and swelling. Farma J. 2019;4(1):305.
21. Sheikh FA, Hussain MA, Ashraf MU, Haseeb MT, Farid-ul-Haq M. Linseed hydrogel based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection. Saudi Pharm J. 2020 May 1;28(5):538–49.
22. Teaima M, Hamid MMA, Shoman NA, Jasti BR, El-Nabarawi MA. Promising swellable floating bupropion tablets: Formulation, in vitro/in vivo evaluation and comparative pharmacokinetic study in human volunteers. Drug Des Devel Ther [Internet]. 2020 Jul 1 [cited 2023 Feb 3];14:2741–57. Available from: http://doi.org/10.2147/DDDT.S258571
23. Gundu R, Pekamwar S, Shelke S, Shep S, Kulkarni D. Sustained release formulation of Ondansetron HCl using osmotic drug delivery approach. Drug Dev Ind Pharm [Internet]. 2020 Mar 3 [cited 2024 Jun 23];46(3):343–55. Available from: https://www.tandfonline.com/doi/abs/10.1080/03639045.2020.1716372
24. Labot JM, Manzo RH, Allemandi DA. Double-layered mucoadhesive tablets containing nystatin. AAPS PharmSciTech [Internet]. 2002 [cited 2021 Apr 7];3(3):1–6. Available from: https://pubmed.ncbi.nlm.nih.gov/12916937/
25. Singh K, Mishra A, Singh A. Synthesis Characterization and In Vitro Release Study of Ciprofloxacin-Loaded Chitosan Nanoparticle. Bionanoscience [Internet]. 2018 Mar 1 [cited 2024 Jun 23];8(1):229–36. Available from: https://link.springer.com/article/10.1007/s12668-017-0470-7
26. Jatav R, Singh D, Rathore P, Prakash Jain N, Goswami RB, Jatav Students of MPharm R. FORMULATION AND EVALUATION OF FLOATING PELLETS OF AMOXICILLIN TRIHYDRATE FOR ERADICATION OF H.PYLORI. World J Pharm Res [Internet]. 2021 [cited 2023 Feb 14];10(9):1024–47. Available from: www.wjpr.net
27. Dumpa NR, Bandari S, Repka MA. Novel gastroretentive floating pulsatile drug delivery system produced via hot-melt extrusion and fused deposition modeling 3D printing. Pharmaceutics [Internet]. 2020 Jan 8 [cited 2021 Apr 6];12(1). Available from: /pmc/articles/PMC7023033/
28. Raza A, Bukhari NI, Karim S, Hafiz MA, Hayat U. Floating tablets of minocycline hydrochloride: Formulation, in-vitro evaluation and optimization. Futur J Pharm Sci. 2017 Dec 1;3(2):131–9.
29. Iglesias N, Galbis E, Romero-Azogil L, Benito E, Lucas R, García-Martín MG, et al. In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations. Pharmaceutics [Internet]. 2020 Jul 7 [cited 2023 Feb 10];12(7):636. Available from: https://www.mdpi.com/1999-4923/12/7/636/htm
30. Noreen M, Farooq MA, Ghayas S, Bushra R, Yaqoob N, Abrar MA. Formulation and in vitro characterization of sustained release tablets of lornoxicam. Lat Am J Pharm. 2019;38(4):701–11.
31. Manogna K, Nagaveni P, Thyagaraju K. A Review On Mucoadhesive Bilayer Buccal Tablets. Am J PharmTech Res. 2018;8(1):101–15.
32. Patel MB, Shaikh F, Patel V, Surti NI. Application of simplex centroid design in formulation and optimization of floating matrix tablets of metformin. J Appl Pharm Sci [Internet]. 2017 [cited 2023 Feb 3];7(04):23–030. Available from: http://www.japsonline.com
33. Huh HW, Na YG, Kang HC, Kim M, Han M, Pham TMA, et al. Novel self-floating tablet for enhanced oral bioavailability of metformin based on cellulose. Int J Pharm. 2021 Jan 5;592:120113.
34. Kumar SA, Debnath M, Anusha K, Manna K, Rao JS. Studies on Formulation Development and Evaluations on Losartan Floating and Bioadhesive Drug Delivery System. Pakistan J Pharm Res. 2017;3(2):84–98.
35. Nigusse B, Gebre-Mariam T, Belete A. Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride. PLoS One [Internet]. 2021 Jun 1 [cited 2023 Feb 14];16(6):e0253391. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253391
36. Varshi R, Jain V, Pal P. A review on Advanced approaches and polymers used in gastroretentive drug delivery systems. J Drug Deliv Ther [Internet]. 2022 Jul 15 [cited 2023 Feb 10];12(4):181–5. Available from: http://www.jddtonline.info/index.php/jddt/article/view/5422/4793
37. Bhatt P, Patel D, Patel A, Patel A, Nagarsheth A. Oral Controlled Release Systems: Current Strategies and Challenges. In: Novel Drug Delivery Technologies: Innovative Strategies for Drug Re-positioning [Internet]. Springer, Singapore; 2019 [cited 2024 Jun 23]. p. 73–120. Available from: https://link.springer.com/chapter/10.1007/978-981-13-3642-3_4
38. Iqbal DN, Tariq M, Khan SM, Gull N, Sagar Iqbal S, Aziz A, et al. Synthesis and characterization of chitosan and guar gum based ternary blends with polyvinyl alcohol. Int J Biol Macromol. 2020 Jan 15;143:546–54.
39. Vega MAC, Deng M, Pinal R. Modular solid dosage form design – Application to pH-independent release of a weak-base API. Int J Pharm. 2021 May 15;601:120518.
40. Gull N, Khan SM, Zahid Butt MT, Khalid S, Shafiq M, Islam A, et al. In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study. RSC Adv [Internet]. 2019 Oct 1 [cited 2024 Jun 23];9(53):31078–91. Available from: https://pubs.rsc.org/en/content/articlehtml/2019/ra/c9ra05025f
41. Huang J, Lin H, Peng B, Huang Q, Shuai F, Xie Y. Design and Evaluation of Hydrophilic Matrix System for pH-Independent Sustained Release of Weakly Acidic Poorly Soluble Drug. AAPS PharmSciTech [Internet]. 2018 Jul 1 [cited 2023 Mar 12];19(5):2144–54. Available from: https://link.springer.com/article/10.1208/s12249-018-1008-1
42. Swain RP, Nagamani A, Shankar PU. Formulation and Evaluation of Gastro-bilayer Floating Tablets of Ezetimibe as Immediate Release Layer and Atenolol as Sustained Release Layer. Indian J Pharm Educ Res | [Internet]. 2019 [cited 2023 Jun 21];53(2):S93–103. Available from: www.ijper.org
43. Kumari B, Pandey P, Dureja H. Formulation and Characterization of Gastroretentive Floating Tablets of Atorvastatin Calcium Using Central Composite Design. J Pharm Res [Internet]. 2017 Sep 1 [cited 2021 Apr 4];16(3):247. Available from: http://www.journalofpharmaceuticalresearch.org/index.php/kpc/article/view/118782
44. Ovenseri AC, Uhumwangho UM, Obarisiagbon AJ, Umechukwu CP. Formulation of non-effervescent floating matrix tablets of metronidazole using Abelmoschus esculentus gum as binder and 2-camphanone as sublimating agent. J Phytomedicine Ther. 2020;19(1).
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Jun 24, 2024
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Ahmed Sadiq Sheikh, Faiza Naseem, Hashmat Ullah, Tehmina Rabbani, Saima Mahmood, Pervaiz Akhtar Shah, Mobina Manzoor, Mohammad Younis Baloch, Muhammad Karim Khan, Muhammad Hashim Khan, Tariq Javed, & Sheikh Abdur Rashid. (2024). DESIGN, DEVELOPMENT AND CHARACTERIZATION OF CIPROFLOXACIN BASED FLOATING DRUG DELIVERY SYSTEM. Journal of Population Therapeutics and Clinical Pharmacology, 31(6), 2971-2985. https://doi.org/10.53555/jptcp.v31i6.7173
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Author Biographies
Ahmed Sadiq Sheikh
Faculty of Pharmacy, My University, Islamabad 44000
Faiza Naseem
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Hashmat Ullah
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Tehmina Rabbani
Department of Pharmaceutics, Balochistan University, Quetta, Pakistan;
Saima Mahmood
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Pervaiz Akhtar Shah
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan, Allama Iqbal Campus, Lahore 54000
Mobina Manzoor
Lahore College for Women University
Mohammad Younis Baloch
Department of Pharmacology, University of Balochistan, Quetta, Pakistan
Muhammad Karim Khan
Civil Veterinary Hospital, District Zhob, Balochistan Pakistan
Muhammad Hashim Khan
Institute of Microbiology, Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan 29050 Pakistan
Tariq Javed
Margalla College of Pharmacy, Margalla Institute of Health Sciences, Rawalpindi 46000 Pakistan
Sheikh Abdur Rashid
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
How to Cite
Ahmed Sadiq Sheikh, Faiza Naseem, Hashmat Ullah, Tehmina Rabbani, Saima Mahmood, Pervaiz Akhtar Shah, Mobina Manzoor, Mohammad Younis Baloch, Muhammad Karim Khan, Muhammad Hashim Khan, Tariq Javed, & Sheikh Abdur Rashid. (2024). DESIGN, DEVELOPMENT AND CHARACTERIZATION OF CIPROFLOXACIN BASED FLOATING DRUG DELIVERY SYSTEM. Journal of Population Therapeutics and Clinical Pharmacology, 31(6), 2971-2985. https://doi.org/10.53555/jptcp.v31i6.7173