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Dua Zhaira Zaidi
Asma Shafiq
Muhammad Ishaq
Asmat Ullah Khan
Ismat Zhaira
Nadia sadiq
Hamza Ishtiaq
Najji ullah Malik
Mubasher Ahmed


Hyperprolactinemia, infertility, PCOS


Infertility is the inability to establish a clinical pregnancy after 12 months of regular unprotected sexual intercourse. Infertility can be of two types. When a couple has primary infertility, they are unable to conceive after a year without using birth control.  However, the couple is unable to conceive after the first child if they have secondary infertility. About 21.9% of Pakistanis suffer from this prevalent issue, with 3.5% primary and 18.5% secondary infertility. Female infertility factors can be divided into the following broad categories polycystic ovary syndrome, hormonal disorders, pelvic inflammatory disease, endometriosis, prolactin deficiency, obesity, ovarian failure, lifestyle factors, and hyperprolactinemia. This study aims to find the relation of hyperprolactinemia with infertile women. It was a cross-sectional study with a sample (convenient) size of 108. This study was conducted from June 2023 to December 2023. The results show that 22.2% of infertile women aged 15 to 25 years, 60.2% of infertile women aged 26 to 35 years, and 17.6% of infertile women aged 36 to 45 years were infertile. Moreover, 79.6% of females had hyperprolactinemia and 20.4% had normal prolactin levels. The study also shows that 60.1% of females had primary infertility 39.9% had secondary infertility. Pearson’s Correlation analysis was conducted to see the relationship between infertility and prolactin, PCOS, Blood pressure (BP), and diabetes. There was a significant positive correlation between infertility with prolactin. (p=<0.01) and PCOS(p=<0.01). The sample consisted of 108 participants for both variables. However, diabetes (p=0.351) and BP (p=0.62) show a non-significant negative correlation with infertility types.

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1. Kumar DP, Sangeetha N. Mitochondrial DNA mutations and male infertility. Indian journal of human genetics. 2009 Sep;15(3):93.
2. Thonneau P, Spira A. Prevalence of infertility: international data and problems of measurement. European Journal of Obstetrics & Gynecology and Reproductive Biology. 1991 Jan 4;38(1):43-52.
3. Rai R, Regan L. Recurrent miscarriage. The lancet. 2006 Aug 12;368(9535):601-11.
4. Hakim A, Sultan M. Faatehuddin: Pakistan reproductive health and family planning survey preliminary report. National Institute of Population Studies Islamabad, Pakistan. 2001.
5. Lunenfeld B, Van Steirteghem A. Infertility in the third millennium: implications for the individual, family and society: condensed meeting report from the Bertarelli Foundation's second global conference. Human reproduction update. 2004 Jul 1;10(4):317-26.
6. Shibli-Rahhal A, Schlechte J. Hyperprolactinemia and infertility. Endocrinology and Metabolism Clinics. 2011 Dec 1;40(4):837-46.
7. Belsey MA. The epidemiology of infertility: a review with particular reference to sub-Saharan Africa. Bulletin of the World Health Organization. 1976;54(3):319.
8. Sharma P, Suvama P, Nitin T. Female infertility and its correlation with serum prolactin and TSH concentration-an unmatched case control study. J Pharm Biomed Sci. 2013;30(30):902-7.
9. Goswami B, Patel S, Chatterjee M, Koner BC, Saxena A. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. Journal of reproduction & infertility. 2009 Oct;10(3):207.
10. Idrisa A, Kawuwa MB, Habu SA, Adebayo AE. Prolactin levels among infertile women in Maiduguri, Nigeria. Tropical Journal of Obstetrics and Gynaecology. 2003;20(2):97-100.
11. Crosignani PG. Management of hyperprolactinemic infertility. Middle East Fertility Society Journal. 2012 Jun 1;17(2):63-9.
12. Templeton A, Fraser C, Thompson B. The epidemiology of infertility in Aberdeen. British Medical Journal. 1990 Jul 21;301(6744):148-52.
13. Shibli-Rahhal A, Schlechte J. Hyperprolactinemia and infertility. Endocrinology and Metabolism Clinics. 2011 Dec 1;40(4):837-46.
14. Kaiser UB. Hyperprolactinemia and infertility: new insights. The Journal of clinical investigation. 2012 Oct 1;122(10):3467-8.
15. Shaheen R, Subhan F, Sultan S, Subhan K, Tahir F. Prevalence of infertility in a cross section of Pakistani population. Pakistan Journal of Zoology. 2010 Aug 1;42(4).
16. Ben-Chioma AE, Tamuno-Emine DG. Evaluation of female fertility hormone profile in women with primary and secondary infertility. Int J Sci Res. 2015;4:1583-5.
17. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertility and sterility. 2016 Jul 1;106(1):6-15.
18. Franks S. Polycystic ovary syndrome in adolescents. International journal of obesity. 2008 Jul;32(7):1035-41.
19. Kumar D. Prevalence of female infertility and its socioeconomic factors in tribal communities of Central India. Rural and Remote health. 2007 May 1;7(2):1-5.
20. Oner G. Prolactin and infertility. In Prolactin 2013 Jan 23. IntechOpen.
21. Esmaeilzadeh S, Mirabi P, Basirat Z, Zeinalzadeh M, Khafri S. Association between endometriosis and hyperprolactinemia in infertile women. Iranian journal of reproductive medicine. 2015 Mar;13(3):155.
22. Isah IA, Aliyu IS, Yusuf R, Isah HS, Randawa AJ, Adesiyun AG. Hyperprolactinemia and female infertility: Pattern of clinical presentation in a tertiary health facility in Northern Nigeria. Sahel Medical Journal. 2018 Jan 1;21(1):1.
23. Chaudhry I. Frequency of hyperprolactinemia in female infertility. Pak J Med Health Sci. 2016 Apr 1;10(2):652-3.
24. Idrisa A, Kawuwa MB, Habu SA, Adebayo AE. Prolactin levels among infertile women in Maiduguri, Nigeria. Tropical Journal of Obstetrics and Gynaecology. 2003;20(2):97-100.
25. Avasthi K, Kaur J, Gupta S, Narang PA. Hyperprolactinema and its correlation with hypothyroidism in infertile women. Journal of Obstetrics and Gynaecology of India. 2006;56(1):68-71.

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