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Uterine Fibroid, Leiomyoma, Vitamin-D, Size, Heavy bleeding, dragging pain
Uterine fibroids or leiomyomas are the most common tumors of females in their reproductive life, they usually represent heavy mensural bleeding, dragging abdominal pain, and pressure symptoms, there are numerous uterine fibroid risk factors, and vitamin D deficiency has a significant effect on reproductive women. In general, black women are more likely to suffer from uterine fibroid than other ethnic groups, with estimates of incidence ranging from 5.4% to 77% globally. Uterine fibroid frequency in Pakistan is believed to be around 54%. The treatment options depend upon the size, quantity, and location of the uterine fibroid. Agonists for gonadotropin-releasing hormone, selective progesterone receptor modulators, tranexamic acid, and dydrogesterone, while surgical treatment shrinks the fibroid, medical treatment only reduces the symptoms temporarily. The objective of this study was to assess the decreased Vitamin -D level as a risk factor for developing uterine fibroid. In this study, 5000 IU of vitamin D was given orally as an adjuvant therapy together with 500 mg of tranexamic acid and 10 mg of dydrogesterone. Vitamin D a, steroid hormone with a significant impact on other body areas is vitamin D, Deficiency of vitamin D may strongly correlate with the growth of leiomyomas. Our study concluded that there was evidence of a strong association between the administration of vitamin D and the reduction of the size of uterine fibroid
2. Baird DD, Hill MC, Schectman JM, Hollis BW. Vitamin D and risk of uterine fibroids. Epidemiology (Cambridge, Mass.). 2013 May;24(3):447.
3. Brakta S, Diamond JS, Al-Hendy A, Diamond MP, Halder SK. Role of vitamin D in uterine fibroid biology. Fertility and sterility. 2015 Sep 1;104(3):698-706.
4. Brüggmann D, Louwen F, Braun T, Klingelhöfer D, Bauer J, Bendels MH, Bundschuh M, Quarcoo D, Jaque J, Wanke EM, Groneberg DA. The uterine fibroid/myoma tumour: analysis of the global research architecture using density-equalizing mapping. Reproductive biomedicine online. 2018 Feb 1;36(2):227-38.
5. Chen X, Yang F, Shen Z, Tang X, Yu J, Liu F. Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population. Clinical and Experimental Obstetrics & Gynecology. 2023 Mar 10;50(3):55.
6. Ciavattini, A., Delli Carpini, G., Serri, M., Vignini, A., Sabbatinelli, J., Tozzi, A., Aggiusti, A., & Clemente, N. (2016). Hypovitaminosis D and "small burden" uterine fibroids: Opportunity for a vitamin D supplementation. Medicine, 95(52), e5698.
7. Hajhashemi M, Ansari M, Haghollahi F, Eslami B. The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency. Caspian journal of internal medicine. 2019;10(2):125.
8. Holick MF. Vitamin D deficiency. New England journal of medicine. 2007 Jul 19;357(3):266-81.
9. Munusamy MM, Sheelaa WG, Lakshmi VP. Clinical presentation and prevalence of uterine fibroids: a 3-year study in 3-decade rural South Indian women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017 Dec 1;6(12):5596-602.
10. Sabry M, Halder SK, Allah AS, Roshdy E, Rajaratnam V, Al-Hendy A. Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. International journal of women's health. 2013 Feb 27:93-100.
11. Snellman G, Melhus H, Gedeborg R, Byberg L, Berglund L, Wernroth L, Michaelsson K. Determining vitamin D status: a comparison between commercially available assays. PloS one. 2010 Jul 13;5(7): e11555
12. Suneja A, Faridi F, Bhatt S, Guleria K, Mehndiratta M, Sharma R. Effect of vitamin D3 supplementation on symptomatic uterine leiomyoma in women with hypovitaminosis D. Journal of Mid-life Health. 2021 Jan;12(1):53.
13. Tanha FD, Feizabad E, Farahani MV, Amuzegar H, Moradi B, Sadeh SS. The effect of vitamin D deficiency on overgrowth of uterine fibroids: a blinded randomized clinical trial. International Journal of Fertility & Sterility. 2021 Apr;15(2):95.
14. Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, Al-Hendy A. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocrine reviews. 2022 Aug;43(4):678-719
15. Reference of Software: PASS 2020 Power Analysis and Sample Size Software (2020).NCSS, LLC. Kaysville, Utah, USA, ncss.com/software/pass
16. De la Puente Yagüe, M., Collado Yurrita, L., Ciudad Cabañas, M. J., & Cuadrado Cenzual, M. A. (2020). Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients, 12(2), 579. https://doi.org/10.3390/nu12020 579
17. Dolmans, M. M., Cacciottola, L., & Donnez, J. (2021). Conservative Management of Uterine Fibroid-Related Heavy Menstrual Bleeding and Infertility: Time for a Deeper Mechanistic Understanding and an Individualized Approach. Journal of clinical medicine, 10(19), 4389. https://doi.org/10.3390/jcm10194389
18. Aninye, I. O., & Laitner, M. H. (2021). Uterine Fibroids: Assessing Unmet Needs from Bench to Bedside. Journal of women's health (2002), 30(8), 1060–1067. https://doi. org/10.1089 /jwh.2021.0280
19. Woźniak, A., & Woźniak, S. (2017). Ultrasonography of uterine leiomyomas. Menopa use Review/Przegląd Menopauzalny, 16(4), 113-117.
20. Viva, W., Juhi, D., Kristin, A., Micaela, M., Marcus, B., Ibrahim, A., & Dirk, B. (2021). Massive uterine fibroid: a diagnostic dilemma: a case report and review of the literature. Journal of medical case reports, 15, 1-6.