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Elaeagnus parvifolia, hepatoprotective, renoprotective, antioxidant
The goal of this study was to see how albino mice responded to a hydroethanolic extract of Elaeagnus parvifolia fruits. Phytochemical analysis, FTIR spectroscopy and HPLC, findings confirmed the existence of functional groups and a wide spectrum of phenolic compounds, respectively. Furthermore, extract did not cause significant hemolysis (5.39±0.176%) when compared to PBS (0.103±0.15%) as a negative control; however, it did have significant clot lysis (21.20 ± 2.25%) potential, as well as antioxidant DPPH scavenging (37.023±0.204%), H2O2 scavenging (11.27±0.18%) and reducing power (81.47±0.24%). In vivo experiments in albino mice demonstrated that for 28 days giving extract dosages orally, after CCl4 intoxication significantly (P<0.05) recovered liver enzymes, renal profiles, lipid profile, serum electrolytes and stress markers, additionally the dosage group (200 mg/Kg b.w.) substantially (P<0.05) improved the structural architecture of liver tissue. Elaeagnus parvifolia has a substantial therapeutic response to treat medical difficulties, notably liver disorders, according to the findings.
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