THERAPEUTIC RESPONSE OF ELAEAGNUS PARVIFOLIA’S HYDROETHANOLIC EXTRACT TO RESTORE THE ANTIOXIDANT POTENTIAL, HEPATOPROTECTIVE AND RENOPROTECTIVE EFFECTS.

Main Article Content

Fahad Said Khan
Muhammad Akram
Abid Rashid
Sultan Ayaz Sultan Ayaz
Muhammad Ali Shah

Keywords

Elaeagnus parvifolia, hepatoprotective, renoprotective, antioxidant

Abstract

The goal of this study was to see how albino mice responded to a hydroethanolic extract of Elaeagnus parvifolia fruits. Phytochemical analysis, FTIR spectroscopy and HPLC, findings confirmed the existence of functional groups and a wide spectrum of phenolic compounds, respectively. Furthermore, extract did not cause significant hemolysis (5.39±0.176%) when compared to PBS (0.103±0.15%) as a negative control; however, it did have significant clot lysis (21.20 ± 2.25%) potential, as well as antioxidant DPPH scavenging (37.023±0.204%), H2O2 scavenging (11.27±0.18%) and reducing power (81.47±0.24%). In vivo experiments in albino mice demonstrated that for 28 days giving extract dosages orally, after CCl4 intoxication significantly (P<0.05) recovered liver enzymes, renal profiles, lipid profile, serum electrolytes and stress markers, additionally the dosage group (200 mg/Kg b.w.) substantially (P<0.05) improved the structural architecture of liver tissue. Elaeagnus parvifolia has a substantial therapeutic response to treat medical difficulties, notably liver disorders, according to the findings.

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