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Dr. Lareb Gul
Malik Talha Saad
FNU Anam
Dr. Muhammad Ayoob Memon
Dr Amna Malik
Dr Ali Karim
FNU Simran
Sheena kumari
Mohsin Ali
FNU Partab


COVID-19, Pain Symptoms, Survivors, global health, syndrome


Background: This structured abstract provides a summary of the literature review conducted to investigate the prevalence of the neuropathic component in post-COVID pain symptoms among previously hospitalized COVID-19 survivors.

Methods: A comprehensive literature search was conducted using electronic databases, including PubMed, Google Scholar, and relevant medical journals. Studies focusing on the neuropathic component in post-COVID pain symptoms among COVID-19 survivors were included in the review. Data extraction and analysis were performed to identify common themes and research gaps.

Results: The literature review revealed a limited number of studies specifically examining the prevalence, characteristics, and management of neuropathic pain in post-COVID patients. The available literature mainly focused on the acute phase and immediate complications of COVID-19, overlooking the long-term consequences, including chronic pain. The absence of standardized assessment tools specific to neuropathic pain further hindered the accurate diagnosis and evaluation of neuropathic pain symptoms.

Conclusion: The literature review identified significant research gaps regarding the neuropathic component in post-COVID pain symptoms among previously hospitalized COVID-19 survivors. Further research is needed to address these gaps and improve the understanding, diagnosis, and management of neuropathic pain in this population.

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1. Huang Q, Zhao Y, Gong N, et al. Neuropathic pain in patients after recovery from COVID-19. Pain Pract. 2021;21(5):523-525.
2. Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268-2270.
3. Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40(2):502-509.
4. Hachem LD, Mansfield KE, Patel VM, et al. Persistent hyperinflammation and Long COVID: mechanisms and management. Front Immunol. 2022;13:791212.
5. Donnelly SC, Hasleton PS, Mackenzie IJ, et al. Idiopathic pulmonary fibrosis: usual interstitial pneumonia adjacent to bronchiolar metaplasia and cellular bronchiolitis. Histopathology. 1998;33(3):242-247.
6. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733.
7. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242.
8. Nijs, Jo, et al. "Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition." Biomedicines, vol. 10, no. 10, 2022, p. 2562,
9. Fernández-de-las-Peñas, C.; Navarro-Santana, M.; Plaza-Manzano, G.; Palacios-Ceña, D.; Arendt-Nielsen, L. Time course prevalence of Post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: A systematic review and meta-analysis. Pain 2022, 163, 1220–1231.
10. Soares, F.H.C.; Kubota, G.T.; Fernandes, A.M.; Hojo, B.; Couras, C.; Costa, B.V.; Lapa, J.D.D.S.; Braga, L.M.; Almeida, M.M.; Cunha, P.H.M.D.; et al. “Pain in the Pandemic Initiative Collaborators”. Prevalence and characteristics of new-onset pain in COVID-19 survivours, a controlled study. Eur. J. Pain 2021, 25, 1342–1354.
11. Smart, K.M.; Blake, C.; Staines, A.; Doody, C. Clinical indicators of “nociceptive”, “peripheral neuropathic” and “central” mechanisms of musculoskeletal pain. A Delphi survey of expert clinicians. Man. Ther. 2010, 15, 80–87.
12. César Fernández-de-las-Peñas, Dr. Med, PhD and others, Development of Neuropathic Post-COVID Pain Symptoms Is Not Associated with Serological Biomarkers at Hospital Admission in COVID-19 Survivors: A Secondary Analysis, Pain Medicine, Volume 23, Issue 12, December 2022, Pages 2092–2094,
13. Nijs, Jo, et al. "Precision Management of Post-COVID Pain: An Evidence and Clinical-Based Approach." European Journal of Pain,
14. Torices, S.; Cabrera, R.; Stangis, M.; Naranjo, O.; Fattakhov, N.; Teglas, T.; Adesse, D.; Toborek, M. Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: Implications for HIV-1 infection. J. Neuroinflamm. 2021, 18, 167
15. Herrero-Montes, M.; Fernández-de-las-Peñas, C.; Ferrer-Pargada, D.; Tello-Mena, S.; Cancela-Cilleruelo, I.; Rodríguez-Jiménez, J.; Palacios-Ceña, D.; Parás-Bravo, P. Prevalence of neuropathic component in post-COVID pain symptoms in previously hospitalized COVID-19 survivors. Int. J. Clin. Pract. 2022, 2022, 3532917
16. Fitzcharles, M.A.; Cohen, S.P.; Clauw, D.J.; Littlejohn, G.; Usui, C.; Häuser, W. Nociplastic pain: Towards an understanding of prevalent pain conditions. Lancet 2021, 397, 2098–2110.
17. Jimeno-Almazán, A.; Pallarés, J.G.; Buendía-Romero, Á.; Martínez-Cava, A.; Franco-López, F.; Sánchez-Alcaraz Martínez, B.J.; Bernal-Morel, E.; Courel-Ibáñez, J. Post-COVID-19 syndrome and the potential benefits of exercise. Int. J. Environ. Res. Public Health 2021, 18, 5329
18. Cattadori, G.; Di Marco, S.; Baravelli, M.; Picozzi, A.; Ambrosio, G. Exercise training in post-COVID-19 patients: The need for a multifactorial protocol for a multifactorial pathophysiology. J. Clin. Med. 2022, 11, 2228.
19. Bailly, M.; Pélissier, L.; Coudeyre, E.; Evrard, B.; Bingula, R.; Rochette, C.; Mériade, L.; Blavignac, C.; Fournier, A.C.; Bignon, Y.J.; et al. Systematic review of COVID-19-related physical activity-based rehabilitations: Benefits to be confirmed by more robust methodological approaches. Int. J. Environ. Res. Public Health 2022, 19, 9025
20. Bodes-Pardo, G.; Lluch-Girbés, E.; Roussel, N.A.; Gallego-Izquierdo, T.; Jiménez-Penick, V.; Pecos-Martín, D. Pain neurophysiology education and therapeutic exercise for patients with chronic low back pain: A single-blind randomized controlled trial. Arch. Phys. Med. Rehabil. 2018, 99, 338–347

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