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Najat Rany Kasir
Lisal Sonny Teddy
Idris Irfan
Muis Abdul
Limoa Erlyn
Syamsuddin Saidah


Schizophrenia, Folic acid, Methylcobalamin, Risperidone, Clinical Symptoms, BDNF Serum


Background : Schizophrenia is a mental disorder characterized by delusions, hallucinations, cognitive and affective impairments that impact various aspects of life and society. Schizophrenia patients often have a spectrum of vitamin and mineral deficiencies. Folic acid and methylcobalamin as adjuvant therapy in schizophrenia patients are considered to improve clinical symptoms, maximize the quality of life of schizophrenia patients, and increase BDNF levels, which have been widely studied as a cognitive marker in schizophrenia patients.

Objective: Determine the effect of folic acid and methylcobalamin adjuvant therapy on improving clinical symptoms and BDNF levels in schizophrenic patients receiving risperidone therapy.
Method: We used experimental analysis in our study by measuring pre- and post-tests with non-random group selection. This study was carried out at the Dadi Special Regional Hospital in South Sulawesi Province of Indonesia in February–March 2023, and sample testing was carried out to the HUMRC Research Laboratory of Hasanuddin University. A total of 46 subjects were divided into a treatment group of 23 subjects who received risperidone therapy of 4-6 mg/day plus adjuvant therapy of folic acid and methylcobalamin for 8 weeks and a control group of 23 subjects who only received risperidone therapy of 4-6 mg/day. PANSS was used to assess clinical symptoms, and serum BDNF levels were measured using enzyme-linked immunosorbent assays (ELISA). The Wilcoxon, Mann-Withney, and Spearman correlation tests were carried out to see the significance.

Results: There was a decrease in PANSS both in the treatment group and in the control group after receiving a significant therapeutic dose of antipsychotic risperidone with a p value (< 0,001). The treatment group with risperidone antipsychotic therapy with adjuvants of folic acid and methylcobalamin showed an improvement in clinic symptoms of 63.33 percent, with the clinical interpretation of symptoms showing very much improvement, compared to the control group with a clinical improvement of the symptoms of 46.19 percent, with the clinical manifestation interpretation showing much improvement. There was an increase in the level of BDNF in the treatment group receiving risperidone antipsychotic therapy with adjuvant therapy of folic acid and methylcobalamin, with a significant p value (<0,001) compared to the control group that received only risperidone antipsychotic therapy.

Conclusion: Effects of Folic Acid and Methylcobalamin Adjuvant Therapy and Standard Therapy Risperidone 4-6 mg/day can improve clinical symptoms and increase serum BDNF levels.

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