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Lisal T Sonny
Santy Irma
Bahar Burhanuddin
Wuysang Audry Devisanty
Renaldi Rinvil
Syamsuddin Saidah


Cognitive Function, Homofanilic Acid, Schizophrenia



Background: Study of the supplementation of piracetam on cognitive function and plasma HVA levels in the treatment of schizophrenia in humans had never been conducted before. Meaningful findings in this study could provide information about optimizing pharmacological management in schizophrenic patients by adding piracetam and ultimately will improve the prognosis of the disorder. One of the simple and accurate tools for predicting the cognitive function and the prognosis of schizophrenia treatment is HVA level.


Objective: to determine the effect of piracetam supplementation on cognitive function and homovanillic acid levels in schizophrenic patients treated with risperidone.


Method: This study was experimental study, using a pre- and post-test study design with random group selection, in which variable measurements were carried out before and after treatment, conducted at RSKD Dadi South Sulawesi Province and the blood testing were send to the Research Laboratory of RSPTN UNHAS. The study subject were hospitalized schizophrenia patients who received a therapeutic dose of risperidone as many as 20 subject in treatment groups and 20 subject in control groups. The Moca-Ina were messure at weeks 0 & 8 eather in treatment group (who received Piracetam 2400 mg / day and risperidone 2-4 mg / day) and the contol group (who received risperidone 2-4 mg / day) for 8 weeks. Two measurements of Homovanilic Acid levels with ELISA were carried out in both groups, namely at the beginning of week 0 and weekend 8.


Results: MoCA-Ina values were significantly high in both grups with p <0.05, where the treatment group was higer than the control group with p = 0.015 (<0.05). Plasma homovanilic acid levels was increased in the treatment group, but there was no significant difference between before and after treatment p = 0.065 (> 0.05). There was no direct correlation between plasma homovanilic acid levels and cognitive function with p > 0.05.


Conclusion: supplementation of oral Piracetam 2400 mg/day and risperidone for 8 weeks, was better to improve cognitive function than risperidone alone, there was also a slight increases homofanilic acid levels.

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