PREVALENCE OF DIABETES, CHRONIC LIVER DISEASE, CHRONIC KIDNEY DISEASE AND DYSLIPIDEMIA IN PATIENTS ATTENDING A TERTIARY CARE CENTRE
Main Article Content
Keywords
Metabolic comorbidities, Multimorbidity, Dyslipidemia
Abstract
Metabolic comorbidities such as diabetes, dyslipidemia, obesity, and chronic organ disease are increasingly prevalent among hospitalized adults and contribute significantly to morbidity and mortality.this study aim to evaluate the prevalence of diabetes, dyslipidemia, chronic kidney disease (CKD), and chronic liver disease (CLD) and their patterns of multimorbidity in a tertiary care hospital‑based cohort.
Methods: A cross‑sectional observational study was conducted over 12 months at a tertiary care centre in central India, enrolling 60 consecutive adult patients (≥18 years) with one or more metabolic or chronic conditions. Demographic, clinical, anthropometric, and laboratory data were recorded, and multimorbidity was defined as two or more of the four conditions.
Results: The mean age group was predominantly 41–60 years, with 70% of patients overweight/obese. Dyslipidemia was the commonest condition (63.3%), followed by diabetes (45%), CKD (23.3%), and CLD (15%). Elevated LDL‑C and low HDL‑C were the predominant lipid abnormalities among those with dyslipidemia. A striking 66.7% of patients had two or more concurrent conditions, and diabetic patients had significantly higher rates of dyslipidemia (81.5%) and CKD (37%) compared with non‑diabetic patients (p < 0.05).
Conclusion: Hospitalized adults in this tertiary care setting exhibit a high burden of metabolic multimorbidity, with diabetes strongly associated with dyslipidemia and CKD, underscoring the need for protocol‑driven, integrated management of cardiometabolic risk factors in inpatient care.
References
2. Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014:943162.
3. Kotsis V, Stabouli S, Papakatsika S, et al. Mechanisms of obesity induced hypertension. Hypertens Res. 2010;33(5):386 93.
4. Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham Study. JAMA. 1979;241(19):2035 8.
5. Gupta R, Misra A, Pais P, et al. Escalating epidemic of metabolic syndrome in India. J Assoc Physicians India. 2007;55:775 82.
6. Sharma S, Tripathi S, Singh S, et al. Prevalence of metabolic syndrome in hospital based population in India. Indian J Clin Biochem. 2011;26(3):269 77.
7. Joshi SR, Parikh RM. India—diabetes capital of the world: now what? J Assoc Physicians India. 2007;55:311 3.
8. Li Z, Wang Y, Liu H, et al. High prevalence of diabetes and other comorbidities in hospitalized patients with COVID 19 in Delhi, India, and their association with outcomes. Diabetes Metab Syndr Obes. 2021;14:45 53.
9. Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandhania VK, et al. Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. PLoS One. 2014;9(5):e96808.
10. Mithal A, Majhi D, Shunmugavelu M, Talwarkar PG, Vasnawala H, Raza AS. Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID). Indian J Endocrinol Metab. 2014;18(5):642–647.
11. Singh G, Gupta V, Sharma AK, Gupta N. Recent trends in epidemiology of dyslipidemias in India. Indian Heart J. 2017;69(3):382–392.
12. Anjana RM, Deepa M, Pradeepa R, Mahanta J, Narain K, Das HK, et al. Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR-INDIAB population-based cross-sectional study. Lancet Diabetes Endocrinol. 2017;5(8):585–596.
13. Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007;125:217–230.
14. Kumar P, Krishna P, Reddy SC, Gurappa M, Aravind SR, Munichoodappa C. Incidence of type 1 diabetes mellitus and associated complications among children and young adults: results from Karnataka Diabetes Registry 1995–2008. J Indian Med Assoc. 2008;106(11):708–711.
15. Newtonraj A, Tovia S, Girija G, Manikandan M, Vincent A. Chronic kidney disease among diabetes and hypertensive patients in a remote rural area of South India: A population-based cross-sectional study. Indian J Nephrol. 2021;31(4):420–422.
16. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–272.
17. Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709–733.
18. Duseja A, Singh SP, Saraswat VA, Acharya SK, Chawla YK, Chowdhury S, et al. Non-alcoholic fatty liver disease and metabolic syndrome — Position paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology. J Clin Exp Hepatol. 2015;5(1):51–68.
19. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151–171.
20. Arokiasamy P, Uttamacharya, Jain K. Multi-morbidity, functional limitations, and self-rated health among older adults in India: cross-sectional analysis. BMJ Open. 2017;7(3):e013529.

