FORMULATION AND STABILITY EVALUATION OF TOPICAL PREPARATION CONTAINING SALICYLIC ACID, CITRIC ACID AND SODIUM CITRATE
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Keywords
Salicylic Acid, Topical formulation, Antimicrobial resistance
Abstract
Topical antimicrobial therapy remains vital for localized skin and wound infections, minimizing systemic exposure and side effects. The necessity for developing new antimicrobial means has increased significantly due to growing concerns regarding multidrug-resistant bacterial, viral, and fungal strains. The present research was conducted to formulate and evaluate the stability of a novel antibacterial combination comprising citric acid, sodium citrate, and salicylic acid against multidrug-resistant (MDR) Gram-negative bacterial strains. For this purpose, three-trial formulation(F1-F3) were designed. All formulations exhibited stability with no phase separation. How ever F3 optimized formulation (F3) exhibited ideal semisolid consistency suitable for skin application, maintained pH within the dermatologically acceptable range (4.5–6.5) exhibit excellent spread ability The formulation demonstrated excellent physicochemical stability, with no phase separation or microbial contamination observed during the testing period. This formulation exhibited promising stability and favourable physical characteristics, making them suitable candidates for dermatological application.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Anum Tariq
Department of Pharmacy Practice, Ziauddin University, Karachi Pakistan
Mirza Tasawer Baig
Jinnah Sindh Medical University, Karachi Pakistan
Anwar Ejaz Beg
Department of Pharmaceutics, Ziauddin University, Karachi Pakistan
Uzma Shahid
Department of Pharmacology, Ziauddin University, Karachi Pakistan
Minahil Baig
Federal Medical College (PIMS), SZABMU, Islamabad Pakistan
Muhammad Aurangzeb Khan
Shaheed Benazir Bhutto Dewan University, Karachi Pakistan
