TRIGLYCERIDE-GLUCOSE INDEX: A POTENTIAL SURROGATE FOR INSULIN RESISTANCE IN PREDICTING THE RISK OF DIABETIC NEPHROPATHY
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Abstract
This study was performed to explore how the triglyceride-glucose (TyG) index is related to insulin resistance, as measured by HOMA-IR, in patients newly diagnosed with type 2 diabetes mellitus (T2DM). It also examined how the TyG index is linked to UACR, a marker often used to detect early signs of diabetic nephropathy.
Study Design: Cross-sectional observational study.
Study Duration: This study was conducted at Peoples University of Medical and Health Sciences for Women Shaheed Benazirabad Nawabshah Hospital from March 2024 to March 2025
Methods:
An observational, cross-sectional study was carried out over a one-year. The study included adult patients with a recent diagnosis of T2DM. Data collected encompassed demographics (age, gender), clinical details (BMI, vitals, duration of diabetes), and key biochemical measurements: HOMA-IR, serum creatinine, TyG index, lipid profile, fasting plasma glucose, spot UACR, and fasting insulin. There were 4 quartiles in which the participants were categorized based on their TyG index scores; Quartile 1 (4.5 to 5), quartile 2 ( 5.1 to 5.5), quartile 3 (5.6 to 6), and quartile 4 (Above 6)
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Ashok Kumar Maheshwari
Ashok Kumar Maheshwari, Family Physician Medicine, Thumbay Group Sharjah UAE.
Iqra Badar
Iqra Badar, Consultant Physician, Peoples University of Medical and Health Sciences for Women Shaheed Benazirabad Nawabshah Pakistan.
Kehf
Kehf, Consultant Physician, Peoples University of Medical and Health Sciences for Women Shaheed Benazirabad Nawabshah Pakistan.
Saleem Shahzad
Saleem Shahzad, Associate Professor Medicine, Jinnah Post Graduate Medical Center Karachi. Pakistan.
Reema Akbar
Reema Akbar, Consultant Physician, Liaquat University of Medical and Health Sciences Jamshoro Pakistan
Suresh Kumar
Suresh Kumar, Assistant Professor Medicine, Bhitai Dental and Medical college Mirpurkhas Pakistan.