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Muhammad Muddasser khan Panezai
Naeema Asghar
Muhammad Rashid Qureshi
Mehwish Abrar
Saleem Shahzad
Kamran Ali Qureshi


diabetic nephropathy, type 2 diabetes, TyG index, HOMA-IR


Background: Diabetes mellitus (DM) damages blood vessels, kidneys, eyes, nerves, and the heart by increasing blood sugar levels and changing metabolism. A total of 10.5% of people worldwide suffered from diabetes in 2021; by 2030, that number is projected to increase to 643 million, and by 2045, it will reach 783 million. Pakistan has over 33 million people with a diabetes prevalence of 26.7%. Due to the slow course of type 2 diabetes mellitus (T2DM), patients should be screened for diabetic nephropathy (DN) at diagnosis and then once a year thereafter. Insulin-resistant kidneys exhibit hyper filtration, which is associated with the progression of diabetic nephropathy (DN) and severe illness. Microalbuminuria, which indicates endothelial dysfunction, can be treated early.

Objective: To determine the association of TyG index with HOMA-IR in T2DM patients, and to determine the association of TyG index with UACR for predicting DN.

Study design: A cross-sectional study

Place and Duration: This study was conducted in Sandeman Provincial Hospital Quetta from March 2023 to March 2024.

Methodology: The sample was acquired from Diabetic Clinic patients using a non-probability consecutive sampling technique. The study comprised T2DM patients with fasting plasma glucose (FPG) values of ≥126 mg/dl and a diagnosis of 1-5 years. Data was collected after patients provided informed consent and ensured their confidentiality. The demographic and clinical data gathered were gender, age, height, diabetes duration, blood pressure (BP), waist circumference (WC), weight, and body mass index (BMI).

Results: In all, 250 patients were included in this investigation. There were 88 (35.2%) male participants and 162 (64.8%) female participants, making up the majority of the participants. Overall 49.2 years of age was the average. Overall 3.46 was the mean fasting serum insulin. The mean HOMA-IR was 1.79. The mean glycated hemoglobin was 6.65. The mean TyG index levels were 5.39. 46% of the participants were overweight while 15% were obese and 39% were normal weighted.

Conclusion: The TyG index showed a strong connection with HOMA-IR and was superior in predicting diabetic nephropathy (DN) in type 2 diabetes patients.

Abstract 57 | pdf Downloads 16


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