SAFETY, SIDE EFFECTS, AND PATIENT PROFILE IN LETROZOLE STEP-UP VS CONVENTIONAL PROTOCOLS FOR OVULATION INDUCTION IN UNEXPLAINED INFERTILITY
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Keywords
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Abstract
Objective: To evaluate and compare the safety profile, side effects, and patient demographics in women undergoing ovulation induction using letrozole step-up protocol versus conventional dosage protocol as part of intrauterine insemination (IUI) for unexplained infertility.
References
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2. Mitwally MF, Casper RF. Letrozole for ovulation induction. Expert Rev Obstet Gynecol. 2006;1(1):15-27.
3. Kar S. Current evidence supporting “letrozole” for ovulation induction. J Hum Reprod Sci. 2013;6(2):93-8.
4. Homburg R. Clomiphene citrate—end of an era? A mini-review. Hum Reprod. 2005;20(8):2043-51.
5. Badawy A, Metwally M, Fawzy M. Randomized controlled trial of three doses of letrozole for ovulation induction in patients with unexplained infertility. Reprod Biomed Online. 2007;14(5):559-62.
6. Kaur J, Suri V, Gainder S, Arora A. Prospective randomized trial comparing efficacy of letrozole step-up protocol with letrozole plus gonadotropins for controlled ovarian stimulation and intrauterine insemination in patients with unexplained infertility. Arch Gynecol Obstet. 2019;300(6):1767-71.
7. Ali HA et al. Letrozole step-up versus fixed-dose protocols in ovulation induction in patients with unexplained infertility. Int J Chem Biochem Sci. 2024;25(14):100-108.
8. Zolton JR et al. Gonadotropins versus oral ovarian stimulation agents for unexplained infertility: a systematic review and meta-analysis. Fertil Steril. 2020;113(2):417-25.