Role of IVIM MRI in staging and restaging of rectal cancer

Main Article Content

Hayder Jasim Taher
Ayoob Dinar Abdullah
Hayder Suhail NajmAlareer
Hussein Abed Dakhil
Ahmed Mohmedbaqer Easa
Raad Ajeel Bustan


IVIM MRI, rectal cancer, staging, restaging, meta-analysis


Background: IVIM is a noninvasive method that analyses both the mobility of free water particles and the perfusion generated by microcirculation in vivo using a biexponential mathematical model with varied b values .
Aim: To evaluate Role of IVIM MRI in staging and restaging of rectal cancer.
Methodology: A comprehensive search was conducted for papers that looked into the role of IVIM MRI in rectal cancer staging and restaging. The pooled specificity, sensitivity, constructed summary receiver - operating characteristic characteristics curve, and positive likelihood ratio were estimated after the data was extracted.
Results: After a full-text review, 11 studies were found to be qualified. Specificity and sensitivity were 81 percent (0.83-0.91) and 86 percent (0.77-0.87), respectively, in the pooled data. The area under the receiver operating characteristic curve using summarized receiver operating characteristics was 0.97.
Conclusions: According to this meta-analysis, IVIM MRI is an accurate, noninvasive diagnostic tool for staging and restaging rectal cancer.

Abstract 245 | pdf Downloads 100


1. Beets-Tan, R. G., & Beets, G. L. MRI for assessing and predicting response to neoadjuvant treatment in rectal cancer. Nature Reviews Gastroenterology & Hepatology. 2014, 11(8), 480-488.
2. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of
incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer
3. ZADEH, Firoozeh Abolhasani, et al. Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells. Rendiconti Lincei. Scienze Fisiche e Naturali, 2022, 1-7 .
4. ROHMAH, Martina Kurnia, et al. Modulatory role of dietary curcumin and resveratrol on growth performance, serum immunity responses,
mucus enzymes activity, antioxidant capacity and serum and mucus biochemicals in the common carp, Cyprinus carpio exposed to abamectin. Fish & Shellfish Immunology, 2022, 129: 221-230 .
5. ARIF, Anam, et al. The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.
International Immunopharmacology, 2023, 114: 109581 .
6. MARGIANA, Ria, et al. Functions and therapeutic interventions of non-coding RNAs associated with TLR signaling pathway in atherosclerosis. Cellular Signalling, 2022, 100: 110471
7. H. A. Al-Hchaimi, M. F. Alhamaidah, H. Alkhfaji, M. T. Qasim, A. H. Al-Nussairi and H. S. Abd-Alzahra, "Intraoperative Fluid
Management for Major Neurosurgery: Narrative study," 2022 International Symposium on Multidisciplinary Studies and Innovative
Technologies (ISMSIT), 2022, pp. 311-314, doi: 10.1109/ISMSIT56059.2022.9932659 .
8. LEI, Zimeng, et al. Detection of abemaciclib, an anti-breast cancer agent, using a new electrochemical DNA biosensor. Frontiers in
Chemistry, 2022, 10 .
9. BASHAR, Bashar S., et al. Application of novel Fe3O4/Zn-metal organic framework magnetic nanostructures as an antimicrobial agent and
magnetic nanocatalyst in the synthesis of heterocyclic compounds. Frontiers in Chemistry, 2022, 10 .
10. Granata, V., Grassi, R., Fusco, R., Izzo, F., Brunese, L., Delrio, P., ... & Petrillo, A. Current status on response to treatment in locally
advanced rectal cancer: what the radiologist should know. Eur Rev Med Pharmacol Sci. 2020, 24(23), 12050-12062 .
11. Gollub, M. J., Gultekin, D. H., Akin, O., Do, R. K., Fuqua, J. L., Gonen, M., ... & Schwartz, L. H. Dynamic contrast enhanced-MRI for the
detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer. European radiology. 2012, 22(4), 821-831 .
12. Hu, H., Jiang, H., Wang, S., Jiang, H., Zhao, S., & Pan, W. 3.0 T MRI IVIM-DWI for predictingthe efficacy of neoadjuvant chemoradiation for
locally advanced rectal cancer. Abdominal Radiology. 2021, 46, 134-143.
13. Intven, M., Reerink, O., & Philippens, M. E. P. Diffusion-weighted MRI in locally advanced rectal cancer , 2013 .
14. Oto, A., Yang, C., Kayhan, A., Tretiakova, M.,Antic, T., Schmid-Tannwald, C., ... & Stadler, W. M. Diffusion-weighted and dynamic contrastenhanced MRI of prostate cancer: correlation of quantitative MR parameters with Gleason score and tumor angiogenesis. American Journal of Roentgenology. 2011, 197(6), 1382-1390.
15. Pham, T. T., Liney, G. P., Wong, K., & Barton, M. B. Functional MRI for quantitative treatment response prediction in locally advanced rectal cancer. The British journal of radiology, 90(1072), 20151078 .
16. Prezzi, D., & Goh, V. (2016). Rectal cancer magnetic resonance imaging: imaging beyond morphology. Clinical Oncology. 2017, 28(2), 83-
92 .
17. Vuik, F. E., Nieuwenburg, S. A., Bardou, M., Lansdorp-Vogelaar, I., Dinis-Ribeiro, M., Bento, M. J., ... & Spaander, M. C. Increasing incidence
of colorectal cancer in young adults in Europe over the last 25 years. Gut. 2019, 68(10), 1820-1826 .
18. Yildirim, M., & Koc, M. The Role of Diffusion MRI in Rectum Cancer Staging and Evaluation of Neoadjuvan Treatment Efficiency. International Journal of Hematology & Oncology/UHOD: Uluslararasi Hematoloji Onkoloji Dergisi. 2020, 30(4).

Most read articles by the same author(s)