CORRELATION BETWEEN SERUM URIC ACID LEVEL AND THE SEVERITY OF CORONARY ARTERY DISEASE
Main Article Content
Keywords
Coronary artery disease, Serum uric acid, Gensini score, Cardiovascular risk, Hyperuricemia, Angiographic severity, Spearman correlation
Abstract
This study aims at the evaluation of the correlation between level of serum uric acid (SUA) and the extent of coronary artery disease (CAD) using angiographic scoring.
Study design: Cross-sectional study
Duration and place of study: This study was conducted in Peoples University of Medical and Health Sciences for Women Shaheed Benazirabad Nawabshah from May 2023 to May 2024
Methodology
150 patients diagnosed with CAD through coronary angiography were included in this study. The severity of CAD was assessed using the Gensini score. SUA levels were measured and categorized. Statistical correlation between uric acid levels and CAD severity was analyzed using Spearman’s rank correlation. Data analysis was performed using SPSS version 25.
Results
Among the 150 patients enrolled, the age range was 40 to 70 years. The mean age of patients was 58.6 ± 11.7 years. Males comprised 72.7% (n=109) of the sample. The mean SUA level was 6.84 ± 1.65 mg/dl, while the average Gensini score was 54.2 ± 18.9. A significant association of SUA and Gensini score (r = 0.462) was observed, indicating a moderately strong relationship. Elevated uric acid levels were more frequently noted in patients with higher Gensini scores.
Conclusion
This study found a strong association between elevated SUA levels and the severity of coronary artery disease, suggesting its potential role as a non-invasive marker for CAD risk stratification.
References
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Imran Ellahi Soomro
Imran Ellahi Soomro, Associate Professor Cardiology, Peoples University Of Medical And Health Sciences For Women Shaheed Benazirabad Nawabshah Pakistan
Qurban Ali Rahu
Qurban Ali Rahu, Professor Cardiology, Peoples University Of Medical And Health Sciences For Women Shaheed Benazirabad Nawabshah Pakistan.
Atif Ahmed Khan
Atif Ahmed Khan, Assistant Professor Adult Cardiology, Sindh Institute Of Cardiovascular Diseases Hyderabad Pakistan
Muhammad Waqas
Muhammad Waqas, Assistant Professor Adult Cardiology, Sindh Institute Of Cardiovascular Diseases Karachi Pakistan.
Atia Ayoob
Atia Ayoob, Senior Registrar Cardiology, Peoples University Of Medical And Health Sciences For Women Shaheed Benazirabad Nawabshah Pakistan
Shahbaz Ali
Shahbaz Ali, Associate Professor Adult Cardiology, Sindh Institute Of Cardiovascular Diseases Hyderabad Pakistan.