IMPACT OF METABOLIC AND ENDOCRINE DISORDERS ON UTERINE AND OVARIAN CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Keywords
Uterine Cancer, Ovarian Cancer, Metabolic Disorders, Endocrine Disorders, Obesity, Diabetes, Polycystic Ovary Syndrome (PCOS), Thyroid Dysfunction, Hormonal Regulation, Systematic Review, Meta-Analysis
Abstract
Uterine and ovarian carcinoma are some of the most frequent gynecologic cancers in women throughout the world. Metabolic and endocrine syndromes have been suggested as potential risk factors for these malignancies. Because of the complicated relationship between the metabolic regulation, metabolic pathways, and cancer development, we conducted a systematic review and meta-analysis of the association of metabolic and endocrine disorders with the risk of uterine and ovarian cancer. This work is a review of observational studies, clinical trials and cohort studies that summarize of the main metabolic and endocrine disorders (obesity, diabetes); polycystic ovary syndrome (PCOS) and thyroid dysfunction) and their association with these neoplasms. The results indicate that some of the metabolic and hormonal disturbances are related to risk of uterine and ovarian cancer. The objective is to provide an in-depth understanding of the biological background of these associations and the clinical conse- quences to the risk assessment and prophylactic management of cancer in women with metabolic and endocrine disorders.
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Dr Najma parveen
MBBS from liaquat University of medical and health sciences Jamshoro
Dr Rabia Bibi
liaquat university of medical and health sciences FCPS OBS & GYNAE/ MRCOG/MrCPI
Dr Amina majid khuwaja
Liaquat university of medical and health sciences
Dr. Amna Najam
Assistant Professor Obs/Gynae Al-Nafees Medical College and Hospital Islamabad.
Dr Samreen Mahboob
MBBS: KARACHI UNIVERSITY FCPS ( OBS & GYNAE)
Dr. Amber Shams
Mbbs: Liaquat University Of Medical And Health Sciences Jamshoro ,Pakistan: Mrcpi1,Fcps-1(Gynae & Obs)