In vitro Anti-inflammatory activity of Silymarin/Hydroxyapatite/Chitosan Nanocomposites and its cytotoxic effect using Brine shrimp lethality assay Nanocomposite for biomedical applications

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Rajeshkumar S
Aravind Kumar Subramanian
Ramachandra Prabhakar
Raj Vikram N
saravanan dinesh SP


Nanocomposites, Anti-inflammatory, Cytotoxic, Chitosan, silymarin


The bioactive compound silymarin is one of the most prominent drug used in liver diseases. The chitosan and hydroxyapatite is major materials used in many biomedical applications such as drug delivery, osteointegration etc. The nanoparticles and nanocomposites are advanced materials with many biomedical applications in diagnosis and therapeutics. In this present investigation we have used Silymarin a bioactive compound, hydroxyapatite and chitosan a polymeric material and based different combinations. The prepared individual materials and nanocomposites were used for the anti-inflammatory activity and brine shrimp lethality assay. The results are clearly shows that the nanomcposites are very good anti-inflammatory agent with lower toxicity. 

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