PROBIOTICS AS AN ADJUNCT THERAPY FOR PREVENTION OF ANTIBIOTIC-ASSOCIATED DIARRHEA IN CHILDREN: SYSTEMATIC REVIEW
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Keywords
Probiotics, antibiotic-associated diarrhea, pediatric, gut microbiota, Lactobacillus, Bifidobacterium, Saccharomyces boulardii, adjunct therapy, prevention, systematic review
Abstract
Antibiotic related diarrhea (ARD) is one of the most common side effects experienced in children who take antibiotics, because of alteration in the composition of intestinal microflora. The purpose of this systematic review is to assess the effectiveness of probiotics as an additional treatment intervention to guard against AAD in children. The literature databases referencing this topic were searched exhaustively with articles published between January 2000 and December 2023 filtering according to the set criteria. The systematic review incorporated 11 pieces of research featuring different probiotic species including Lactobacillus, Bifidobacterium, and Saccharomyces boulardii and observed that AAD incidence was lowered by up to 58%. These results suggest that, if more advanced studies are conducted with a focus on different strains, doses, and treatment durations, probiotics could have a beneficial effect in limiting AAD. In conclusion, prophylactic use of probiotics appears to be reasonably safe and effective in decreasing the incidence, intensity, and duration of AAD in children, but more properly designed studies are needed to establish an ideal protocol for using probiotics as an adjunct therapy.
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