EFFICACY AND SAFETY OF IV IRON SUCROSE IN CHILDREN TREATED FOR IRON DEFICIENCY ANEMIA
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Keywords
Iron deficiency anemia, Intravenous sucrose, Children, Efficacy
Abstract
Background and Aim: Mostly cases of iron deficiency anemia caused by childhood malnutrition managed with oral iron supplements. However, intravenous (IV) iron is an option for those with severe Iron deficiency anemia who struggle with oral absorption of iron supplementation. Therefore, the present study aimed to investigate the efficacy and safety of intravenous (IV) iron sucrose in children treated for iron deficiency anemia.
Patients and Methods: Experimental research was conducted by giving intravenous iron sucrose to the patents between age of 3 months to 12 years, presented with iron deficiency anemia, within a control setting of Paediatrics intensive care unit CMH Peshawar. Routine blood screening including Hb, serum ferritin, MCV, MCHC, HCT, etc count and RBC count were done and results were recorded prior to IV iron therapy. IV iron sucrose was given with maximum dose of 7mg/kg every 3 to 7 days (not exceeding than 300mg/dose) until total dose is given. The patients were followed and relevant laboratory tests were repeated after one month of last dose of IV iron therapy. Demographics, baseline characteristics, and laboratory parameters such as hemoglobin levels, ferritin levels, and other associated variables were recorded for each patient. SPSS version 26 was used for descriptive statistics.
Results: The overall mean age was 5.36 ± 4.56 years (age range 0-15 years). The Nutritional iron deprivation was the most prevalent cause of iron deficiency anemia. The mean value of hemoglobin (g/dL) at baseline and after 30 days was 7.21 ± 0.74 and 11.86 ± 0.76, respectively. There were 41 (53.9%) male and 35 (45.1%) female. Prior to IV treatment, the mean corpuscular volume (MCV) was 64.83 ± 4.49 fL, which increased to 89.16 ± 7.69 fL after 30 days treatment. Similarly, there was significant difference observed in ferritin levels before (6.89 ± 4.45 μg/L) and after (48.59 ± 4.79 μg/L) the treatment.
Conclusion: Administration of IV sucrose for the treatment of iron deficiency anemia is effective, safe, and can significantly improve iron and hemoglobin levels.
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Dr Aqib Rashid Aqib
Pediatric Department Combined Military Hospital, Peshawar Pakistan
Dr Faryal Ali
Pediatric Department Combined Military Hospital, Peshawar Pakistan
Dr Maarij Ullah Shah
Pediatric Department Hayatabad Medical Complex, Peshawar Pakistan
Dr Muhammad Saeed
Pediatric Department Combined Military Hospital, Peshawar Pakistan
Ayesha Usman
Final Year MBBS, Khyber Girls Medical College, Peshawar Pakistan
Dr Aamir Iqbal
Pediatric Department Combined Military Hospital, Peshawar Pakistan