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Psoriasis, Interleukin-30, Cytokines, Psoriasis pathogenesis, PASI
Psoriasis is a common chronic immune-mediated inflammatory skin disorder characterized by
erythematous silvery scaling of the skin and associated severe itching. Reports indicate that
psoriasis is affecting about 2% of world population and life quality in a way that limits the
patient activity and thereby productivity in a community. Therefore, determining appropriate
therapeutics for psoriasis would make a difference in the lives of the patients and their
communities. To address this, scientists have been working on different biological agents, such
as interleukins and their antagonists, to regulate the common inflammatory process in psoriasis.
For the current research project, serum was collected from 26 psoriatic patients and another 26
health controls, and the serums were examined for the level of IL-30 to determine differences
among the tested groups and to investigate a possible correlation between IL-30 and PASI
(psoriasis area severity index). The study delineated differences of the IL-30 among the groups
and a positive correlation between IL-30 and PASI among the psoriatic cases, which insights a
need for further studies that include a large scale of participants to fully elucidate the
involvement of IL-30 in psoriasis.
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