INFLUENCE OF ETHANOL, ISOPROPYL MYRISTATE & PROPYLENE GLYCOL ON IN VITRO PERMEATION OF DIMENHYDRINATE FROM TRANSDERMAL GEL
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Keywords
carbopol 934P, consistency, gel, in vitro, permeation enhancer
Abstract
Carbopol 934P, the gelling agent utilized in the investigation and assessment, exhibits good consistency and tolerable flow behavior. The best result was obtained from the organoleptic, physicochemical determination. Formulations F14–F18 displayed varying release patterns during in vitro evaluation, however formulation F15 demonstrated the most consistent and optimal outcomes. The acquired data demonstrated that a combination of 2% ethanol, 1.75% isopropyl myristate, and 74.5% propylene glycol as a concentration is promising to boost dimenhydrinate permeability from transdermal gel. Using the Carbopol 934P gelling agent, the other outcomes, such as the organoleptic and flow properties, were successfully and effectively attained. Conclusion: Compared to other combinations of permeation enhancing agents, the use of ethanol as a permeation enhancer in combination with isopropyl myristate and propylene glycol is superior. Additionally, carbopol is a promising gelling agent that can be used to make gel dosage forms.
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Sadaf Hayat Laghari
College of Pharmacy, Liaquat University of Medical, and Health Sciences Jamshoro
Imran Suheryani
Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh Jamshoro
Abdullah Dayo
Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh Jamshoro
Komal Zaman
College of Pharmacy, Liaquat University of Medical, and Health Sciences Jamshoro
Raheela Saleem
College of Pharmacy, Liaquat University of Medical, and Health Sciences Jamshoro
Nimra Zaman
People's primary healthacre initiative (PPHI)
Ubed-Ur-Rehman
Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh Jamshoro
Syed Zohaib Hussain
Department of Pharmacy Nazeer Hussain University karachi
Jabbar Abbas
Peoples University of Medical and Health Sciences for women Nawabshah (SBA)