CLINICO-PATHOLOGICAL CORRELATION OF LESIONS IN LEPROSY IN A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY
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Keywords
Leprosy, Clinico-pathological, Fite-faraco stain, skin biopsy
Abstract
Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae. India continues to account for 53.6% of newly reported cases per year across the globe. Leprosy mainly affects the skin and peripheral nerves. It presents with various clinical and Histopathological forms depending on the Host cellular immune response. Histopathological examination and demonstration of lepra bacilli is an important tool for accurate diagnosis and typing of leprosy.
Aim: To assess clinico-pathological correlation of lesions in leprosy.
Materials and Methods:
A cross-sectional study on 20 skin biopsy specimens of clinically diagnosed leprosy patients conducted for a period of 3 months in the Pathology Department, SVMC, Tirupati. Skin biopsies were received, processed and stained with H&E stain followed by Fite-Faraco stain to diagnose histopathological types of leprosy and clinico-histopathological correlation was done.
Results:
In this study, majority of the cases (45%) occurred in the 41-60 years age group. Male to female ratio was 1.5:1. Borderline tuberculoid leprosy (8 cases, 40%) was the most common type followed by lepromatous leprosy (4 cases, 20%). Fite-faraco was found positive in all cases of lepromatous leprosy (LL), borderline lepromatous (BL) and histoid leprosy. Clinico-pathological concordance was seen in 55% of cases.
Conclusion:
Histopathological examination along with Fite-faraco staining is recommended in all clinically suspected cases of leprosy which will help in accurate diagnosis and subtyping of leprosy.
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Dr. Shaik Mehaboob Basha
Postgraduate, Department of Pathology, S.V.Medical College, Tirupati.
Dr. U. Parameswari Babu
Assistant Professor, Dept. of Pathology, S.V.Medical College, Tirupati.
Dr. B. Nagaraja
Professor, Department of Pathology, S.V.Medical College, Tirupati).
Dr. G. Indrani
Professor & HOD, Department of Pathology, S.V.Medical College, Tirupati.
Dr. Md. Khader Faheem. N
Associate Professor, Dept. Of Pathology, S.V.Medical College, Tirupati
Dr. Sujatha
Assistant Professor, Dept. Of Pathology, S.V.Medical College, Tirupati.