A HISTOPATHOLOGICAL ANALYSIS OF MAST CELLS IN ATHEROMATOUS LESIONS: AN AUTOPSY BASED STUDY
Main Article Content
Keywords
.
Abstract
Atherosclerosis is a chronic degenerative condition of the arteries that causes major cardiovascular morbidity and mortality around the world. In the Indian subcontinent, it is estimated to be responsible for more than 25% of deaths (1). It starts developing at an earlier age and is found to be in more advanced stages in the Indian population as compared to the patients in western nations. It can induce a variety of problems such as myocardial infarction (MI), stroke, embolization, ulceration, thrombosis, and aneurysm, all of which cause significant morbidity and mortality, impacting the lifespan and quality of life (2). High cholesterol and triglycerides levels have been linked to obesity, increased risk of atherosclerosis, and shorter life span (3).
References
2. Vyas P, Gonsai RN, Meenakshi C, Nanavati MG. Coronary atherosclerosis in noncardiac deaths: An autopsy study. J Midlife Health.2015 Jan -Mar;6(1):5-9.
3. Palatine P, Julius S. Elevated heart rate: a major risk factor for cardiovascular disease. Clin Exp Hypertens 2004; 26(7-8):637-44.
4. Bot I, Bison EAL. Mast cells in atherosclerosis. Thromb Haemost 2011;106(5):820-6.
5. Kelley JL, Chi DS, Abou-Auda W, Smith JK, Krishnaswamy G. The molecular role of mast cells in atherosclerotic cardiovascular disease. Mol Med Today. 2000;6(8):304-08.
6. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN, et al. Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20: 1262-75.
7. Kaartinen M, Penttila A, Kovanen PT. Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Circulation. 1994;90: 1669-78.
8. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull Jr W, Rosenfeld ME, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1994;89: 2462-78.
9. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull Jr W, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995; 92:1355-74.
10. Patil P, Muthuveilu N, Ahmed S, Chaudhary AS. A histopathological study of mast cells in atheromatous lesions on autopsy specimens. Natl J Lab Med.2021 Apr;10(2): PO29-PO33.
11. Garg M, Aggarwal AD, Kataria SP. Coronary atherosclerosis and myocardial infarction an autopsy study. J Indian Acad Forensic Med. 2011; 33:39-42.
12. Gupta R, Gupta JK, Basal R, Vashisha J, Mahout M, Kala A, Parmar RB. Atherothrombotic risk factors and premature coronary heart disease in India: a case control study. Indian J Med Res. 2011 jul; 134(1):26-32.
13. Bhargava MK, Bhargava SK. Coronary atherosclerosis in North Karnataka. Indian J Pathol Microbiol. 1975; 18:65–77.
14. Yazdi SAT, Rezaei A, Azari JB, Hejazi A, Shakeri MT, Shahri MK. Prevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death. Iranian J Pathol. 2009; 4(3):101–104.
15. Singh H, Oberoi SS, Gorea RK, Bal MS. Atherosclerosis in coronaries in Malwa region of Punjab. JIAFM. 2005; 27:236–9.
16. Sudha ML, Sundaram S, Purushothaman kumar PS, Prathiba D. Coronary atherosclerosis in sudden cardiac death: An autopsy study. Indian J Pathol Microbiol 2009; 52(4):486-9.
17. kovanen PT, Kaartinen M, Paavonen T. Infiltrates of activated mast cells at the site of Coronary atheromatous erosion or rupture in myocardial infarction. Circulation.1995; 92:1084-88.
18. Jeziorska M, McCollum C, Woolley D. Mast cell distribution, activation and phenotype in atherosclerotic lesions of human carotid arteries. J Pathol.1997; 182:115-22.