Analgesic effect of Ascorbic Acid versus Aceclofenac on Post-transalveolar Extraction - A case control study

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Nallan CSK Chaitanya
Rajkumar Badam
G Siva Prasad Reddy
AdityaMohan Alwala
Pallerla Srinivas
Nisheeth Saawarn
Chintada Suvarda
Mule Akhila
Parinita Bontala
Pavitra Inamdar
Himabindu Mannava


Third molar extraction; IV Vitamin C; Aceclofenac; Post-surgical pain; Trismus; Facial swelling.



One of the most important aspects of postsurgical care is finding an efficient way for management of pain. Third molar extractions/ surgical impaction is one of the most frequent surgical procedure in dental offices and it is most often associated with postoperative complications like severe pain, oedema and reduced mouth opening. This present study was aimed to evaluate efficacy of 2 grams IV Vitamin C compared to Aceclofenac 100 mg on postsurgical pain, swelling and trismus after surgical removal of third molars. Material and Methods: A total of 101 patients recruited for the study and they were randomized into two treatment groups; group A (n=51) received 2g IV Vitamin C and group B (n=50) received aceclofenac 100mg. Pain intensity, facial swelling and mouth opening were assessed till day 3 post surgically. Results: Statistical analysis of pain intensity revealed that IV vitamin C performed slightly better but not significantly differed (p>0.05) from aceclofenac group at end of day 3. No significant difference for facial swelling and mouth opening between the two treatment protocols was seen (p>0.05). Conclusion: Our results concluded that both treatment groups were overall similar in analgesic efficacy, postoperative oedema and reduction in mouth opening. It was also determined that 2g IV Vitamin C is well- suited to the treatment of post-operative pain, swelling and trismus following surgical extraction of impacted third molars.

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