EVALUATION OF ANTI-DIABETIC, ANTI-EPILEPTIC AND CARDIO PROTECTIVE ACTIVITIES BERCHEMIA PAKISTANICA

Main Article Content

Abdul Jabbar
Iqbal Azhar
Shafi Muhammad
Shahlla Imam
Mohammad Arslan
Nagina Soomer Khan
Nisar Ahmad Shahwani
Muhammad Younis
Ghulam Mustafa
Abdul Qadir

Keywords

Anti-diabetic, Anti-epileptic, Cardioprotective, Berchemia pakistanica

Abstract

Berchemia pakistanica is a medicinal plant of Balochistan, used for treatment of various diseases intraditional medicine. In current study, preliminary phytochemical tests, FT-IR studies, determinationof the heavy metal concentrations, acute toxicity, anti-diabetic, anti-epileptic and cardioprotectiveactivitieswereevaluated.Inpreliminaryphytochemicaltests,alkaloids,saponins,flavonoids,glycosides, Terpenoids and tannins were present. In FT-IR studies presence of various functionalgroups were confirmed. The concentration of Se, Cr, Co, Sb and Mn were within the permitted limit.Up to dose of 5000 mg/kg B. pakistanica did not showed any sign of toxicity. B. pakistanica ethanolextractshowedsignificant(p<0.05)anti-diabeticeffectsandalloxaninduceddiabetes.B.pakistanicaethanol extract also showed significant (p<0.05) anti-epileptic effects in strychnine and picrotoxininducedanti-convulsantactivity.InCardioprotectiveactivityB.pakistanicaethanolextractproducedsignificant (p<0.05) protective effects. It is concluded that B. pakistanica showed significant anti-diabetic, anti-epileptic and cardioprotective activities and can be used as an alternative drug formanagementofEpilepsy,diabetes and asan cardioprotectiveagent.

Abstract 91 | PDF Downloads 23

References

1. Achour, S., Chebaibi, M., Essabouni, H., Bourhia, M., Ouahmane, L., Mohammad Salamatullah, A., ... & Giesy, J. P. (2022). Ethnobotanical study of medicinal plants used as therapeutic agents to manage diseases of humans. Evidence-Based Complementary and Alternative Medicine, 2022.
2. Arshad, U., Sajjad, A., ul Haq, I., & Anjum, S. (2023). Phytochemical, antimicrobial and elemental status of three anti-diabetic medicinal plants of Balochistan, Pakistan. Pure and Applied Biology (PAB), 12(1), 357-364.
3. Bibi, T., Ahmad, M., Tareen, N. M., Jabeen, R., Sultana, S., Zafar, M., & Zain-ul-Abidin, S. (2015). The endemic medicinal plants of Northern Balochistan, Pakistan and their uses in traditional medicine. Journal of ethnopharmacology, 173, 1-10.
4. Mukhtar, N., Malik, A., Riaz, N., Iqbal, K., Tareen, R. B., Khan, S. N., ... & Choudhary, M. I. (2004). Pakistolides A and B, Novel Enzyme Inhibitory and Antioxidant Dimeric 4‐(Glucosyloxy) Benzoates from Berchemia pakistanica. Helvetica chimica acta, 87(2), 416-424.
5. Inoshiri, S., Sasaki, M., Kohda, H., Otsuka, H., & Yamasaki, K. (1987). Aromatic glycosides from Berchemia racemosa. Phytochemistry, 26(10), 2811-2814.
6. Karrat, L., Abajy, M. Y., & Nayal, R. (2022). Investigating the anti-inflammatory and analgesic properties of leaves ethanolic extracts of Cedrus libani and Pinus brutia. Heliyon, 8(4).


7. Khanal, L. N., Sharma, K. R., Pokharel, Y. R., & Kalauni, S. K. (2022). Phytochemical Analysis and In Vitro Antioxidant and Antibacterial Activity of Different Solvent Extracts of Beilschmiedia roxburghiana Nees Stem Barks. The Scientific World Journal, 2022.
8. Saleem, A., Afzal, M., Naveed, M., Makhdoom, S. I., Mazhar, M., Aziz, T., ... & Alshammari, A. (2022). HPLC, FTIR and GC-MS Analyses of Thymus vulgaris Phytochemicals Executing in vitro and in vivo Biological Activities and Effects on COX-1, COX-2 and Gastric Cancer Genes Computationally. Molecules, 27(23), 8512.
9. Dghaim, R., Al Khatib, S., Rasool, H., & Ali Khan, M. (2015). Determination of heavy metals concentration in traditional herbs commonly consumed in the United Arab Emirates. Journal of environmental and public health, 2015.
10. Nalimu, F., Oloro, J., Peter, E. L., & Ogwang, P. E. (2022). Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats. BMC complementary medicine and therapies, 22(1), 1-14.
11. Khan, S. U., Ullah, F., Hussain, M., Ihsan, M. Z., Mehmood, S., Ali, L., ... & Hussain, M. I. (2023). Phytochemical analysis and phytotoxic evaluation of Chenopodium glaucum L. Journal of King Saud University-Science, 35(3), 102571.
12. Ullah, R., & Alqahtani, A. S. (2022). GC-MS analysis, heavy metals, biological, and toxicological evaluation of Reseda muricata and Marrubium vulgare methanol extracts. Evidence-Based Complementary and Alternative Medicine, 2022.
13. Singh, R., Khalid, M., Batra, N., Biswas, P., Singh, L., & Bhatti, R. (2023). Exploring the Anticonvulsant Activity of Aqueous Extracts of Ficus benjamina L. Figs in Experimentally Induced Convulsions. Journal of Chemistry, 2023.
14. Vinogradova, N., Glukhov, A., Chaplygin, V., Kumar, P., Mandzhieva, S., Minkina, T., & Rajput,
V. D. (2023). The Content of Heavy Metals in Medicinal Plants in Various Environmental Conditions : A Review. Horticulturae, 9(2), 239.
15. Mansouri, R. A., Ahmad, A., Alshaibi, H. F., & Ragab, M. (2023). Pharmacological Studies on the Antidiabetic, Antioxidant, and Antimicrobial Efficacies of Commiphora myrrha Resin in Streptozotocin-Induced Diabetes in Rats: A Preclinical Study. Journal of Diabetes Research, 2023.
16. Murwanti, R., Nurrochmad, A., Gani, A. P., Sasmito, E., Edwina, A. E., Chandra, M. K., ... & Budiningsih, J. L. (2023). Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri
L. in Sprague–Dawley Rats. Journal of Toxicology, 2023.
17. Gamde, S. M., Ugwah-Oguejiofor, C. J., Garba, A., Avwioro, G. O., Moronkeji, A., & Jimoh, A.
A. (2023). Histologic and Biochemical Effect of Balanite aegyptiaca Fruit Extract on Alloxan- Induced Diabetes in Wistar Rats. Ethiopian Journal of Health Sciences, 33(3).
18. Dra, L. A., Sellami, S., Rais, H., Aziz, F., Aghraz, A., Bekkouche, K., ... & Larhsini, M. (2019). Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi journal of biological sciences, 26(6), 1171-1178.
19. Imtiaz, F., Islam, M., Saeed, H., Ahmed, A., & Rathore, H. A. (2023). Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan‐induced diabetic mouse model. The FASEB Journal, 37(4), e22818
20. Macdonald Ighodaro, O., Mohammed Adeosun, A., & Adeboye Akinloye, O. (2017). Alloxan- induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina, 53(6), 365-374.
21. Aljazzaf, B., Regeai, S., Elghmasi, S., Alghazir, N., Balgasim, A., Hdud Ismail, I. M., ... & Alghazeer, R. (2023). Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study. Oxidative Medicine and Cellular Longevity, 2023.
22. Nadig, A. P., Suman, Sahyadri, M., Mehdi, S., & Krishna, K. L. (2022). Aqueous extract of Piper betle L. leaf and Areca catechu L. nut protects against pentylenetetrazole-induced seizures and


positively modulates cognitive function in adult Zebrafish. Advances in Traditional Medicine, 1- 16.
23. Usman, S., Ahmad, M. M., Tahir, A., & Umar, A. K. (2023). Exploring the Antiepileptic Potential of Amaranthus spinosus: An Experimental Study in Albino Mice. Sciences of Pharmacy, 2(3), 106-114.
24. Ugwah-Oguejiofor, C. J., Amuda, M. B., Abubakar, K., Ugwah, O. M., Ofokansi, M. N., & Mshelia, H. E. (2023). An experimental evaluation of anticonvulsant activity of aqueous extract of Caralluma dalzielii NE Brown. Phytomedicine Plus, 3(1), 100401.
25. Fisseha, N., Shibeshi, W., & Bisrat, D. (2021). Evaluation of anticonvulsant activity of 80% methanolic root bark extract and solvent fractions of pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice. Advances in Pharmacological and Pharmaceutical Sciences, 2021, 1-7.
26. Bachheti, R. K., Worku, L. A., Gonfa, Y. H., Zebeaman, M., Pandey, D. P., & Bachheti, A. (2022). Prevention and treatment of cardiovascular diseases with plant phytochemicals: A review. Evidence-Based Complementary and Alternative Medicine, 2022.
27. Khan, M., Manzoor, Z., Rafiq, M., Munawar, S. H., Waqas, M. Y., Majeed, H., ... & Mojzych, M. (2022). Phytochemical Screening, Anti-Inflammatory, and Antidiabetic Activities of Different Extracts from Caralluma edulis Plant. Molecules, 27(16), 5346.
28. Gaichu, D. M., Mathabe, P., & Ngugi, M. P. (2023). Evaluation of cardiopreventive effects of Ximenia americana (Linn.) and Pappea capensis (Eckl. and Zeyh.) leaf aqueous extracts in rat models with myocardial infarction. Future Journal of Pharmaceutical Sciences, 9(1), 1-18.
29. Nyamweya, B., Rukshala, D., Fernando, N., de Silva, R., Premawansa, S., & Handunnetti, S. (2023). Cardioprotective Effects of Vitex negundo: A Review of Bioactive Extracts and Compounds. Journal of evidence-based integrative medicine, 28, 2515690X231176622.
30. Kosanam, S., & Pasupula, R. (2021). A Review on Cardioprotective Mechanism of Chemical Constituents of Medicinal Plants. Journal of Pharmaceutical Research International, 33(54A), 104-114.

Most read articles by the same author(s)

1 2 > >>