EVALUATION OF ANTI-ULCER, LAXATIVE AND ANTI-INFLAMMATORY ACTIVITIES OF TECOMELLA UNDULATA (ROXB.)

Main Article Content

Mohammad Arsalan
Iqbal Azhar
Shafi Muhammad
Shahlla Imam
Ghulam Razzaque
Abdul Jabbar
Abdul Qadir
Nagina Soomer Khan
Muhammad Younis
Nisar Ahmad Shahwani
Ghulam Mustafa
Taufiq Ahmed

Keywords

Tecomella undulata, anti-ulcer, Laxative, Anti-inflammatory, Balochistan

Abstract

Tecomella undulata (Bignoniaceae) is a well-known medicinal plant used for the treatment of ulcers and constipation. The present study was carried out to determine phytochemical tests, FT-IR studies, heavy metal concentrations, anti-ulcer, laxative, and anti-inflammatory activities of the ethanolic extract of T. undulata leaves. Phytochemical tests were conducted to detect the presence of alkaloids, flavonoids, saponins, tannins, glycosides, anthraquinones, and terpenoids. FT-IR studies were performed to identify different functional groups. The concentration of heavy metals (Cu, Cr, Mn, Ni, Se, and Sb) was determined using atomic absorption spectroscopy. In the anti-ulcer activity, an ethanol-induced gastric ulcer model was employed. Laxative activity was evaluated using loperamide-induced constipation. In the phytochemical tests, the presence of glycosides, alkaloids, tannins, terpenoids, flavonoids, saponins, and anthraquinones was confirmed. FT-IR studies confirmed the presence of different functional groups (C–N, C-O, N=O, C=C, C=O, C-H, O-H). The concentration of Cu, Cr, Mn, Ni, and Se was within the permitted limits, while the concentration of Sb exceeded the permitted limits. The ethanolic extract of T. undulata exhibited protective effects against ethanol-induced gastric ulcers. The results showed a significant (p<0.05) decrease in the ulcerative index, reduction in inflammation, erythema, and edema in macroscopic evaluation. In the laxative activity test, a significant (p < 0.05) increase in fecal volume, feed intake, and water intake was observed, indicating improved intestinal movement in constipated rats. In anti-inflammatory activities, T. undulata ethanolic extract demonstrated significant (p<0.05) anti-inflammatory effects in carrageenan and formalin-induced rat paw edema. The results of the present study indicate that the crude ethanolic extract of T. undulata possesses significant anti-ulcer, laxative, and anti-inflammatory activities.

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