ESTIMATING THE NEUROCOGNITIVE EFFECTS OF AN EARLY INTERVENTION PROGRAM FOR CHILDREN WITH PRENATAL ALCOHOL EXPOSURE

Main Article Content

Parvaneh Yazdani
Mary Motz
Gideon Koren

Keywords

.

Abstract

Background


Animal studies suggest that early intervention in pups exposed heavily to ethanol in utero can mitigate their neurocognitive damage. No human studies on this promising mechanism exists.


 


Methods


Breaking the Cycle is an early intervention program for drug-and alcohol addicted mothers and their young children. We compared BSID-III scores between infants heavily exposed to ethanol and a group exposed only to drugs of abuse, mainly cocaine. Both groups benefited from all aspects of our early intervention program.


 


Results


The two groups did not differ in any aspect of the BSID-III. These data are in contradistinction to the damage seen in heavily ethanol- exposed infants not benefiting from early intervention.


 


Conclusions


This pilot suggests that early intervention may mitigate some of the well described damages caused by heavy in utero alcohol exposure.

Abstract 378 | PDF Downloads 83

References

1. Koren G, Nulman I, Chudley AE, Loocke C. Fetal alcohol spectrum disorder. CMAJ 2003; 169: 1181-5.
2. Mattson SN, Riley EP, Gramling L, Delis DC, Jones KL. Heavy prenatal alcohol exposure with or without physical features of fetal alcohol syndrome leads to IQ deficits. J Pediatr 1997: 131; 718-21.
3. Bailey BN, Delaney-Black V, Covington CY, Ager J, Janisse J, Hannigan JH, Sokol RJ. Prenatal exposure to binge drinking and cognitive and behavioral outcomes at age 7 years. Am J Obstet Gynecol 2004: 191; 1037-43.
4. Willford J, Leech S, Day N. Moderate prenatal alcohol exposure and cognitive status of children at age 10. Alcohol Clin Exp Res 2006: 30; 1051- 9.
5. Sussman R, Koren G. Attenuating the effects of prenatal alcohol exposure with postnatal interventions: Critical review of animal studies and applications to clinical research. JFAS Int 2006: 4; e13.
6. Testa M, Quigley B, Das Eiden R. The effects of prenatal alcohol exposure on infant mental development: A meta-analytical review. Alcohol and Alcoholism 2003: 38; 295-304.
7. Bayley N. (2006). Bayley Scales of Infant Development, 3rd Ed. The Psychological Corporation, New York, NY.
8. Blair C, Ramey CT. (1997). Early intervention for low birth-weight infants and the path to second generation research. In M.G. Guralnick (Ed).The Effectiveness of Early Intervention. London: Paul H. Brookes.
9. Levine S. Stimulation in infancy. Scientific American 1960: 202; 80-86.
10. Ramey CT. (1988) Educational intervention for high-risk children. Abstract in program for Key Issues in Mental Retardation Research. 8th World Congress of the IASSMD, Dublin.
11. National Research Council and Institute of Medicine, From Neurons to Neighborhoods: The Science or Early Child Development. Jack Shonkoff and Deborah A. Phillips, eds. Washington, CD: National Academy Press, 2000.
12. Center on the Developing Child. Harvard University, A Science-Based Framework for Early Childhood Policy: Using Evidence to Improve Outcomes in Learning, Behavior, and Health for Vulnerable Children. Center on the Developing Child, Harvard University, 2007. www.developingchildharvard.edu
13. Olds D. The nurse-family partnership: an evidence-based preventive intervention. Infant Mental Health Journal 2006: 27(1); 5-25.
14. ZERO TO THREE Policy Centre, Early Experiences Matter. ZERO TO THREE, 2009. www.zerotothree.org
15. Suchman N, Pajulo M, DeCoste C, Mayes L. Parenting Interventions for Drug-Dependent Mothers and Their Young Children: The Case for an Attachment-Based Approach. Family Relations 2006: 55; 211-226.
16. Motz M, Leslie M, Pepler DJ, Timothy E, Freeman PA. Breaking the Cycle: Measures of Progress 1995-2005. JFAS Int 2006: 4; e22.
17. Avner M, Koren G. Breaking the Cycle: A unique model for FASD research. JFAS 2004: 2; e3.

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>