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Maryam Khalid
Dr Mehak Khalid
Mohsin aslam
Dr Shahzeera begum
Shamshad Kousar Chaudhary
Unsa Nasir
Mahe-e-Kamil Qureshi Hashmi
Dr Amber Jamil Siddiqi




Background & Introduction: Karl Landsteiner made a major contribution to the history of transfusions of blood in 1900 when he first introduced the ABO blood type system. In the particular setting of the Pakistani community living in Islamabad, this study explores the connection between ABO blood types and the incidence of the hepatitis C virus (HCV).


Objectives: This study is aimto investigate association of ABO and Rh blood group system among both genders in HCV patients and to investigate which blood group is more prone to HCV in Tertiary Care Hospital Islamabad.



Study setting: Institute of Medical Lab Technology, Isra University Islamabad Campus in collaboration with Tertiary Care Hospital Islamabad.


Sample size: 12353 blood donors out of them 12284 were males and 68 females.


Study duration: 6 months from September 31st 2023 to December 31st 2023.


Data analysis: Data was analyzed using SPSS Version 22. Descriptive statistics was applied.


Results: Among 12353 volunteer donors the findings reveal that males were more prone to HCV as compared to females because, males are significant donors. This finding also reveals that individuals with blood group B positive exhibit the highest frequency of HCV, while those with AB negative blood group manifest the lowest incidence. Notably, blood groups A positive and O positive demonstrated higher frequencies than B positive, aligning with the general prevalence observed in the population.


Conclusion: In summary, while our study finds no direct link between blood group and HCV. The elevated occurrence of HCV among males’ underscores gender differences in HCV distribution, aligning with existing literature. It identifies a higher prevalence in blood group B positive individuals.

Abstract 142 | PDF Downloads 54


1. Kariuki SN, Menendez MA, Introini V, Ravenhill BJ, Lin YC, Macharia A, etal. Makale J, Tendwa M, Nyamu W, Kotar J, Carrasquilla M. Red blood cell tension protects against severe malaria in the Dantu blood group. Nature. 2020 ;585(7826):579-83.
2. Sherif MS. Genotypic And Allelic Frequencies Of Abo And Rh Blood Groups Among Students Of Butajira Preparatory School, Gurage Zone, Southern Nations, Nationalities And Peoples’regional State, Ethiopia. Website: [http://ir.haramaya.edu.et/hru/handle/123456789/325?show=full] Accessed on Dec15th 2023.
3. Abegaz SB. Human ABO blood groups and their associations with different diseases. BioMed research international. 2021;6629060:1-9. DOI: https://doi.org/10.1155/2021/6629060
4. Hosseini N, Shor J, Szabo G. Alcoholic hepatitis: a review. Alcohol Alcohol. 2019;54(4):408-416. DOI:10.1093/alcalc/agz036.
5. Gehrie EA. Transfusion‐transmitted viral infections (TTVIs). Rossi's Principles Transfusion Med. 2022;16:507-522. DOI: 10.1002/9781119719809.ch44
6. Guntipalli P, Pakala R, Gara KS, Ahmed F, Bhatnagar A, Coronel EMK, etal. Worldwide prevalence, genotype distribution and management of hepatitis C. ActaGastroenterol. 202;84(4):637-656.
7. Akoolo L, Rocha SC, Parveen N. Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens. Frontiers in Microbiology. 2022 Nov 25;13:1020029.
8. Hollande C, Parlati L, Pol S. Micro‐elimination of hepatitis C virus. Liver Int. 2020;40(1):67-71.DOI: 10.1111/liv.14363.
9. Noreen M, Imran M, Safi SZ, Bashir MA, Alkhuriji AF, Alomar SY, etal. Association of blood groups with hepatitis C viremia. Saudi J Biol Sci. 2021;28(9):5359-5363.
10. Behal R, Jain R, Behal KK, Dhole TN. Variation in the host ABO blood group may be associated with susceptibility to hepatitis C virus infection. Epidemiol Infect. 2019;138(8):1096-1099
11. Jeremiah ZA, Koate B, Buseri F, Emelike F. Prevalence of antibodies to hepatitis C virus in apparently healthy Port Harcourt blood donors and association with blood groups and other risk indicators. Blood Transfus. 2018;6(3):150.
12. Abdullah S, Karunamoorthi K. Malaria and blood transfusion: major issues of blood safety in malaria-endemic countries and strategies for mitigating the risk of Plasmodium parasites. Parasitol Res. 2020; 115(1):35-47. DOI: 10.1007/s00436-015-4808-1.
13. Rong X, Lu L, Wang J, Xiong H, Huang J, Chen J, etal. Correlation of viral loads with HCV genotypes: higher levels of virus were revealed among blood donors infected with 6a strains. PLoS One. 2019;7(12): e52467.
14. Alqahtani SM, A. Alsagaby S, Mir SA, Alaidarous M, Bin Dukhyil A, Alshehri B, Banawas S, Alturaiki W, Alharbi NK, Azad TA, Al Abdulmonem W. Seroprevalence of viral hepatitis B and C among blood donors in the Northern Region of Riyadh Province, Saudi Arabia. InHealthcare 2021 Jul 24 (Vol. 9, No. 8, p. 934). MDPI.
15. Abebe M, Alemnew B, Biset S. Prevalence of hepatitis B virus and hepatitis C virus among blood donors in nekemte blood bank, Western Oromia, Ethiopia: retrospective 5 years study. Journal of blood medicine. 2020 Dec 31:543-50