Main Article Content

Sarah Awad
Amira Shahid Sheikh
Dr. Mubashir Ahmad
Dr. Fahad Abid
Zahra Mazhar
Dr. Syed Hyder Raza


Depression, Adolescence, Medicine, Mental Health


Introduction: Depression is a pervasive psychological condition impacting individuals of all ages, with particularly severe implications for young people and children, affecting their social, academic, and familial functioning. This study investigates the intake of antidepressants and associated side effects among adolescents.

Methods: An integrated review approach was employed, utilizing databases such as PubMed, SciELO, VHL, and LILACS. Keywords including Depression, adolescence, mental health, and antidepressant medications were used to retrieve relevant English-language human research published within the last 20 years.

Results: Pharmacotherapy plays a vital role in managing depressive disorders in adolescents, according to existing findings and debates. However, it must be part of a comprehensive therapeutic approach rooted in thorough mental health assessments. Despite the importance of antidepressant medication, there remains a scarcity of research on its safety and efficacy in children and young adults.

Conclusion: While antidepressant medication is an essential component of treating Depression in adolescents, its safety and efficacy warrant further investigation. There is a pressing need for more studies to fill the gap in the literature and provide comprehensive guidelines for the use of antidepressants in this vulnerable population.


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1. Ayvaci, E. R., Minhajuddin, A., Elmore, J. S., Yagnik, K., Jha, M. K., Emslie, G. J., . . . Trivedi, M. H. (2024). Treatment of Adolescent Depression: Comparison of Psychiatric and Pediatric Settings at an Academic Medical Center Using the VitalSign6 Application. Journal of Child and Adolescent Psychopharmacology.
2. Ballard, R., Parkhurst, J. T., Gadek, L. K., Julian, K. M., Yang, A., Pasetes, L. N., . . . Sit, D. K. (2024). Bright Light Therapy for Major Depressive Disorder in Adolescent Outpatients: A Preliminary Study. Clocks & Sleep, 6(1), 56-71.
3. Beck, A., Dryburgh, N., Bennett, A., Shaver, N., Esmaeilisaraji, L., Skidmore, B., . . . Goldfield, G. S. (2024). Screening for Depression in children and adolescents in primary care or non-mental health settings: a systematic review update. Systematic Reviews, 13(1), 48.
4. Bennett, J. T., Chung, H., Artz, N., Abraham, V. M., Andrews, A., Wells Jr, D., . . . Remy, C. S. (2024). Does a Preoperative Mental Health Diagnosis Affect Pain Management in Patients With Adolescent Idiopathic Scoliosis Undergoing Surgery? Journal of Pediatric Orthopaedics, 44(1), e35-e39.
5. Binaqail, A., Morinville, V., & Nguyen, V. (2024). A74 A RARE CASE OF ANTIDEPRESSANT-INDUCED LYMPHOCYTIC COLITIS IN A TEENAGER. Journal of the Canadian Association of Gastroenterology, 7(Supplement_1), 51-51.
6. Bojanić, I. (2024). Use of antidepressant and anxiolytic drugs in Scandinavian countries between 2006 and 2021: A prescription database study: Depression and Anxiety, 2024.
7. Boström, A. E. D., Andersson, P., & Lundberg, J. (2024). Antidepressant Use and Manic Episodes in Children and Adolescents With Unipolar Depression. JAMA psychiatry.
8. Bouquillon, L., Bindman, D., Hendriksen, J., Collin, P., Hoskin, J., Conn, R., . . . Quinlivan, R. (2024). Workshop report: Workshop on psychiatric prescribing and psychology testing and intervention in children and adults with Duchenne muscular dystrophy. Research Ideas and Outcomes, 10, e119243.
9. Bruze, G., Järvholm, K., Norrbäck, M., Ottosson, J., Näslund, I., Söderling, J., . . . Neovius, M. (2024). Mental health from 5 years before to 10 years after bariatric surgery in adolescents with severe obesity: a Swedish nationwide cohort study with matched population controls. The Lancet Child & Adolescent Health, 8(2), 135-146.
10. Chrenek, C., Duong, B., Khullar, A., Thomas, R., & Swainson, J. (2024). Use of ketamine for treatment-resistant Depression: an updated review of the literature and practical applications to a community ketamine program in Edmonton, Alberta, Canada. Frontiers in Psychiatry, 14, 1283733.
11. Costa, A. d. A., Almeida, M. T. C., Maia, F. A., Rezende, L. F. d., Saeger, V. S. d. A., Oliveira, S. L. N., . . . Silveira, M. F. (2024). Maternal and paternal licit and illicit drug use, smoking and drinking, and autism spectrum disorder. Ciência & Saúde Coletiva, 29, e01942023.
12. Dauchot, D., Rettey, S., Melton, B. L., & Moeller, K. E. (2024). Antipsychotics in child and adolescent patients with major depressive disorder: A retrospective analysis of prescribing patterns. Mental Health Clinician, 14(1), 10-16.
13. Dragon, J., & Obuchowicz, E. (2024). How Depression and antidepressant drugs affect endocannabinoid system?—review of clinical and preclinical studies. Naunyn-Schmiedeberg's Archives of Pharmacology, 1-26.
14. Galler, A., Thönnes, A., Joas, J., Joisten, C., Körner, A., Reinehr, T., . . . Weghuber, D. (2024). Clinical characteristics and outcomes of children, adolescents, and young adults with overweight or obesity and mental health disorders. International Journal of Obesity, 1-10.
15. Hernandez, R., Xie, D., Wang, X., Jordan, N., Ricardo, A. C., Anderson, A. H., . . . Lash, J. P. (2024). Depressive Symptoms, Antidepressants, and Clinical Outcomes in CKD: Findings from the CRIC Study. Kidney Medicine, 100790.
16. Ho, J. L., Roberts, J., Payne, G. H., Holzum, D. N., Wilkoff, H., Tran, T., . . . Lee, K. C. (2024). Systematic literature review of the impact of psychiatric pharmacists. Mental Health Clinician, 14(1), 33-67.
17. Li, R., Chen, X., Ye, H., & Sheng, X. (2024). Green synthesis of gold nanoparticles from the extract of Crocus sativus to study the effect of antidepressant in adolescence and to observe its aggressive and impulsive behavior in rat models. South African Journal of Botany, 165, 455-465.
18. Lineham, A., Avila-Quintero, V. J., Bloch, M. H., & Dwyer, J. (2024). Exploring Predictors of Ketamine Response in Adolescent Treatment-Resistant Depression. Journal of Child and Adolescent Psychopharmacology.
19. Liu, H., Liu, R., Corrêa, H. L., & Yin, L. (2024). Interactive between sleep and exercise on depressive symptoms in Chinese adolescents. Exploration of major depressive disorder among children and adolescents: From pathogenesis to intervention, 97.
20. Lombardo, C., La Barbiera, C., Mazzola, S., Scaramuzzino, C., Campolo, D., Lakmesari, A. H., & Silvestri, M. C. (2024). Why social media could be dangerous? Suicide risk and mental health challenges in adolescents during COVID-19 pandemic. A narrative review of the literature. Journal of Clinical & Developmental Psychology.
21. Lv, R., Cai, M., Tang, N., Shi, Y., Zhang, Y., Liu, N., . . . Wang, H. (2024). Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial. Trials, 25(1), 44.
22. Mehta, R. K., & Tyagi, R. (2024). Managing Binge Eating Disorder in a Young Adolescent Female: Barriers to Treatment and Recommendations. Cureus, 16(2).
23. Morphett, J., Whittaker, A., Reichelt, A., & Hutchinson, M. (2024). Perineuronal net structure as a non-cellular mechanism contributing to affective State: a scoping review. Neuroscience & Biobehavioral Reviews, 105568.
24. Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., . . . Moresi, M. (2024). Effect of exercise for Depression: systematic review and network meta-analysis of randomized controlled trials. BMJ, 384.
25. Oliva, V., Possidente, C., De Prisco, M., Fico, G., Anmella, G., Hidalgo-Mazzei, D., . . . Fornaro, M. (2024). Pharmacological treatments for psychotic Depression: a systematic review and network meta-analysis. The Lancet Psychiatry, 11(3), 210-220.
26. Orsolini, L., Longo, G., Cicolini, A., & Volpe, U. (2024). An expert opinion on the pharmacological interventions for Disruptive Mood Dysregulation Disorder (DMDD). Expert Opinion on Pharmacotherapy(just-accepted).
27. Samosir, M. N., Keliat, B. A., & Hargiana, G. (2024). EFFECTIVENESS OF COGNITIVE BEHAVIORAL THERAPY IN ADOLESCENTS WITH INTERNET ADDICTION: A SYSTEMATIC REVIEW. Paper presented at the International Conference on Health and Science.
28. Sarakbi, D., Groll, D., Tranmer, J., Kessler, R., & Sears, K. (2024). Supporting Quality Integrated care for Adolescent Depression in Primary care: A Learning System Approach. International Journal of Integrated care, 24(1).
29. Slater, H., AlZubi, Y., Rezaeizadeh, A., Hughes, J. L., Gorman, A., Mayes, T. L., . . . Trivedi, M. H. (2024). Characterizing measurement-based care in the Texas Youth Depression and Suicide Research Network (TX-YDSRN). Child Psychiatry & Human Development, 1-11.
30. Vidal, C., Simon, K., Brooks, C., White, J., & Hinckley, J. D. (2024). A systematic review of evidence on integrated management of psychiatric disorders in youth who use cannabis. Drug and alcohol dependence reports, 100216.
31. Videtta, G., Squarcina, L., Prunas, C., Brambilla, P., & Delvecchio, G. (2024). White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature. Frontiers in Psychiatry, 14, 1335706.
32. Viduani, A., Arenas, D. L., Benetti, S., Wahid, S. S., Kohrt, B. A., & Kieling, C. (2024). Systematic Review and Meta-Synthesis: How do Adolescents experience Depression? A Synthesis of the Qualitative Literature. Journal of the American Academy of Child & Adolescent Psychiatry.
33. Virtanen, S., Lagerberg, T., Lageborn, C. T., Kuja-Halkola, R., Brikell, I., Matthews, A. A., . . . Chang, Z. (2024). Antidepressant use and risk of manic episodes in children and adolescents with unipolar Depression. JAMA psychiatry, 81(1), 25-33.
34. Vöckel, J., Markser, A., Wege, L., Wunram, H. L., Sigrist, C., & Koenig, J. (2024). Pharmacological anti-inflammatory treatment in children and adolescents with depressive symptoms: A systematic review and meta-analysis. European Neuropsychopharmacology, 78, 16-29.
35. Walaszek, M., Kachlik, Z., & Cubała, W. J. (2024). Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention. Nutritional Neuroscience, 1-14.
36. Yang, J., Ying, Y., Jin, L., Ying, F., Fang, J., Chen, X., . . . Yang, X. (2024). Sertraline-Induced Acute Pancreatitis: A Case Report and Literature Review. Alternative Therapies in Health and Medicine, AT10092-AT10092.
37. Yoshida, K., Lunsky, Y., Müller, D. J., & Desarkar, P. (2024). Prevalence of Psychotropic Medication Use and Psychotropic Polypharmacy in Autistic Adults With or Without Intellectual Disability. Journal of Autism and Developmental Disorders, 1-15.
38. Yrondi, A., Javelot, H., Nobile, B., Boudieu, L., Aouizerate, B., Llorca, P.-M., . . . Samalin, L. (2024). French Society for Biological Psychiatry and Neuropsychopharmacology (AFPBN) guidelines for the management of patients with partially responsive Depression and treatment-resistant Depression: Update 2024. L'encephale.
39. Zhang, W. (2024). Systematic review and meta-analysis: Pharmacological and nonpharmacological interventions for disruptive mood dysregulation disorder.
40. Zhao, S., Liang, S., Tao, J., Peng, Y., Chen, S., Wai, H. K., . . . Haqq, A. M. (2024). Probiotics for adults with major depressive disorder compared with antidepressants: a systematic review and network meta-analysis. Nutrition Reviews, nuad171.

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