IMPACT OF GENETIC FACTORS ON KIDNEY STONE SUSCEPTIBILITY AND TREATMENT

Main Article Content

Dr. Bhat Aasim Mohammad
Dr. Mehak Ahsan
Dr. Bakhtawar Bashir
Samah Gaafar Hassan Alshyhi
Dr. Coenrad Adolph Groenewald
Dr. Elma Sibonghanoy Groenewald

Keywords

Urinary Crystals, Identification, Physicochemical, Kidney Stones

Abstract

Background: Kidney stone formation arises from the aggregation of crystals and organic materials within the urinary system, affecting approximately 13% of men and 7% of women globally, with a recurrence rate of up to fifty percent. The accurate detection of kidney stones through laboratory investigations has become pivotal in clinical practice due to its simplicity, speed, and safety, contributing significantly to patient prophylaxis.


Objective: This study aimed to conduct chemical and physical identification of two kidney stones to enhance understanding and diagnostic accuracy. The investigation utilized the Kamlet and Feigl methods, available in the Bioclin® laboratory reagent kit, structured into physical and chemical analysis phases.


Methods: The physical analysis delineated the kidney stone's physical characteristics, while the chemical analysis classified urinary crystals contributing to stone formation. Both samples underwent thorough examination to determine their composition and distinguish any distinct features.


Results: The results yielded satisfactory outcomes, with both samples displaying unique physical properties. Notably, despite physical distinctions, both samples contained calcium oxalate crystals. However, sample B exhibited the presence of uric acid, highlighting the methodology's significance in detecting specific crystal compositions crucial for accurate diagnosis.


Conclusion: The chemical and physical identification of kidney stones, facilitated by methodologies such as the Kamlet and Feigl methods, plays a crucial role in preventing disease relapse, enhancing patient quality of life, and enabling rapid and secure diagnosis. This study underscores the importance of robust laboratory investigations in managing kidney stone-related conditions effectively.

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