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Dr. Javaid Unar
Dr Abdul Aleem
Dr. Saeedullah
Dr. Neha Manzar
Dr. Nabeel Khan
Dr. Faisal Ali Baloch
Murad Khan



Root canal disinfection is a critical aspect of endodontic therapy aimed at eliminating microorganisms and organic debris from the root canal system to facilitate healing and prevent reinfection. Irrigation solutions play a pivotal role in this process by aiding in debris removal, dissolving tissues, and eradicating microorganisms. This quantitative analysis research article evaluates the efficacy of various irrigation solutions in root canal disinfection through a systematic review of ten studies. The included studies encompassed randomized controlled trials, prospective cohort studies, retrospective studies, systematic reviews, and meta-analyses, comparing the efficacy of irrigation solutions such as sodium hypochlorite (NaOCl), chlorhexidine (CHX), hydrogen peroxide (H2O2), and ethylene diamine tetraacetic acid (EDTA). The findings reveal NaOCl's superiority in antimicrobial efficacy, tissue dissolution kinetics, and clinical outcomes compared to alternative solutions. Chlorhexidine offers a safer alternative with comparable antimicrobial efficacy and residual effects between appointments. EDTA enhances root canal disinfection by facilitating smear layer removal, optimizing disinfectant penetration into dentinal tubules. While further research is warranted to standardize irrigation protocols, evaluate long-term clinical outcomes, and mitigate potential adverse effects, the findings underscore the pivotal role of irrigation solutions in achieving optimal root canal disinfection and promoting long-term periapical health. Integration of evidence-based irrigation strategies into clinical practice can enhance the success rates of endodontic therapy and improve patient outcomes.

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