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Shahid Ullah
Syed Meesam Raza
Alkuwaykibi M S
Hedib Alkoumi H Alrawili
Alruwaili A M
Jamal Muhammad Khan


Breast Invasive Carcinoma, Diagnosis, Treatment


The investigation focused on elucidating the role of PDZD2 expression and its regulatory mechanisms in Breast Invasive Carcinoma (BRCA). Employing the UALCAN database, PDZD2 expression analysis unveiled a significant down-regulation in cancerous cells compared to normal controls, suggesting its involvement in BRCA proliferation. Further dissecting PDZD2 expression across various parameters revealed consistent down-regulation in different cancer stages, racial groups, genders, and age categories within BRCA patients, indicative of its pivotal role in disease progression. Additionally, this study explored the promoter methylation status of PDZD2, revealing a significant divergence between BRCA samples and normal controls. Analyzing promoter methylation across different parameters uncovered dynamic variations, with distinct methylation patterns observed across cancer stages, racial groups, genders, and age groups. Survival analysis using the KM plotter tool demonstrated a significant correlation between PDZD2 expression levels and overall survival in BRCA patients, with low PDZD2 expression correlating with higher survival rates. Furthermore, mutational analysis using the cBioPortal platform revealed a mutation rate of 4% in BRCA samples, predominantly featuring amplifications, deep deletions, and some missense mutations in PDZD2. However, these genetic alterations were observed to have minimal impact on PDZD2 dysregulation in BRCA. Collectively, these findings emphasize the multifaceted involvement of PDZD2 in BRCA pathogenesis, emphasizing its potential as a prognostic biomarker and therapeutic target in BRCA management.

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