VITAMIN D DEFICIENCY AND RELATED DISORDERS & EXTRA-MUSCULOSKELETAL ROLES
Main Article Content
Keywords
vitamin D deficiency, osteoporosis type 2 diabetes mellitus, autoimmune diseases, cardiovascular diseases, infectious diseases
Abstract
Vitamin D is a versatile, multifaceted micronutrient with far-reaching implications for human health, making it crucial for maintaining overall health and preventing various diseases and conditions. Its roles extend beyond traditional functions in musculoskeletal health to encompass a broad spectrum of physiological processes across multiple organ systems. The intricate interplay of vitamin D in immune modulation, anti-inflammatory responses, reproductive health, cardiovascular risk, and mental well-being. Further research is warranted to elucidate its precise mechanisms and optimize its therapeutic applications across diverse medical domains. The present review aims to understand the various effects of Vitamin D on the body system.
References
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23. Kamyshna I: The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 2022, 18:379-383. 10.22141/2224-0721.18.7.2022.1210
24. Lisi G, Ribolsi M, Siracusano A, Niolu C: Maternal vitamin D and its role in determining fetal origins of mental health. Current Pharmaceutical Design. 2020, 26:2497-2509.
25. Głąbska D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, Guzek D: Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials. Nutrients. 2023, 15:971.
26. Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, et al.: Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. Nutrients. 2023, 15:1765.
2. Azmi H, Hassou N, Ennaji MM: Chapter 22 - Vitamin D Immunomodulatory Role in Chronic and Acute Viral Diseases. Emerging and Reemerging Viral Pathogens. Ennaji MM (ed): Academic Press; 2020. 489-506. https://doi.org/10.1016/B978-0-12-819400-3.00022-3
3. Baciur P, Chmura A, Skowrońska K, Białas F, Pondel K: The role of Vitamin D in the prevention and treatment of inflammatory skin diseases–atopic dermatitis and psoriasis-literature review. Journal of Education, Health and Sport. 2022, 12:1156-1163.
4. Simpson S, Pal L: Vitamin D and infertility. Current Opinion in Obstetrics and Gynecology. 2023, 35.
5. Renteria K, Nguyen H, Koh GY: The role of vitamin D in depression and anxiety disorders: a review of the literature. Nutritional Neuroscience. 2024, 27:262-270. 10.1080/1028415X.2023. 2186318
6. Benedik E: Sources of vitamin D for humans. International Journal for Vitamin and Nutrition Research. 2021.
7. Thomas L, Xue J, Rieg JAD, Rieg T: A novel role of 1,25(OH)2 vitamin D3 in regulating intestinal Npt2b and renal Npt2c in hypophosphatemia. Physiology. 2023, 38:5734204. 10.1152 /physiol.2023.38.S1.5734204
8. Ahmed LHM, Butler AE, Dargham SR, et al.: Association of vitamin D2 and D3 with type 2 diabetes complications. BMC Endocrine Disorders. 2020, 20. 10.1186/s12902-020-00549-w
9. Malaguarnera L: Vitamin D3 as Potential Treatment Adjuncts for COVID-19. Nutrients. 2020, 12. 10.3390/nu12113512
10. Chevalley T, Brandi ML, Cashman KD, et al.: Role of vitamin D supplementation in the management of musculoskeletal diseases: update from a European Society of Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clinical and Experimental Research. 2022, 34:2603-2623. 10.1007/s40520-022-02279-6
11. Mendes MM, Botelho PB, Ribeiro H: Vitamin D and musculoskeletal health: outstanding aspects to be considered in the light of current evidence. Endocrine Connections. 2022, 11. 10.1530/ec-21-0596
12. Gwenzi T, Zhu A, Schrotz-King P, Schöttker B, Hoffmeister M, Brenner H: Effects of vitamin D supplementation on inflammatory response in cancer and precancerous lesions: systematic review and meta-analysis of randomized trials. Research Square Platform LLC; 2023.
13. The Potential Role of Vitamin D Administration in The Skin Aging Process Through The Inflammatory Pathway: A Systematic Review. Tropical Journal of Natural Product Research. 2023, 7. 10.26538/tjnpr/v7i4.1
14. Al-Saoodi H, Kolahdooz F, Andersen JR, Jalili M: Effect of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis: a systematic review and dose–response meta-analysis of randomized controlled trials. Nutrition Reviews. 2023:nuad083. 10.1093/nutrit/nuad083
15. Gao H, Zhou H, Zhang Z, Gao J, Li J, Li X: Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway. Frontiers in Immunology. 2023, 14. 10.3389/fimmu.2023.1135930
16. Zofou D, Mua HN, Lum GS, et al.: Effect of vitamin D supplementation on the efficacy of anti-diabetic drugs in streptozotocin-induced albino Wistar rat model.
17. Makedou K: "Vitamin D and its Antioxidant and Anti-Inflammatory Role in Cardiovascular Diseases". Biomedical Journal of Scientific & Technical Research. 2023, 50. 10.26717/bjstr.2023.50.007886
18. Al Mheid I, Quyyumi AA: Vitamin D and Cardiovascular Disease: Controversy Unresolved. Journal of the American College of Cardiology. 2017, 70:89-100. https://doi.org/10.1016 /j.jacc.2017.05.031
19. Ismailova A, White JH: Vitamin D, infections and immunity. Reviews in Endocrine and Metabolic Disorders. 2022, 23:265-277. 10.1007/s11154-021-09679-5
20. Wacker M, Holick MF: Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013, 5:111-148. 10.3390/nu5010111
21. Vodolazkaya AN, Orlova SV, Nikitina EA, Prokopenko EV, Pigareva YA, Balashova NV: Potential impact of vitamin D on women’s reproductive health. Medical alphabet. 2023:23-28. 10.33667/2078-5631-2023-8-23-28
22. Reddy AM, Iqbal M, Chopra H, et al.: Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction. EXCLI journal. 2022, 21:967.
23. Kamyshna I: The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 2022, 18:379-383. 10.22141/2224-0721.18.7.2022.1210
24. Lisi G, Ribolsi M, Siracusano A, Niolu C: Maternal vitamin D and its role in determining fetal origins of mental health. Current Pharmaceutical Design. 2020, 26:2497-2509.
25. Głąbska D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, Guzek D: Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials. Nutrients. 2023, 15:971.
26. Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, et al.: Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. Nutrients. 2023, 15:1765.
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Published
Dec 10, 2023
Article Details
How to Cite
Muhammad Abdulrahman Alahmadi, Khaled Mohammed Nasser Awlaqi, Nasser Mohammed Nasser Dhamda, Wed Ali Ibrahem Musayri, Hayt Ali Almashhur, Abdulrahman Yahya Salem Almalki, Hossam Mohammed Ahmed Rayyani, Rawiyah Mohammed Buayti, Mossa Shadad Abdullh Hakami, & Malak Hussain Ahmed Asiri. (2023). VITAMIN D DEFICIENCY AND RELATED DISORDERS & EXTRA-MUSCULOSKELETAL ROLES. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 2137-2143. https://doi.org/10.53555/jptcp.v30i19.4884
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Author Biographies
Muhammad Abdulrahman Alahmadi
King Salman Bin Abdulaziz Medical City (Ksamc) – Medina
Khaled Mohammed Nasser Awlaqi
Eradh & Mental Health-Jazan
Nasser Mohammed Nasser Dhamda
Chest Diseases Hospital – Jazan
Wed Ali Ibrahem Musayri
King Fahd Centeral Hospital-Jazan
Hayt Ali Almashhur
King Fahd Centeral Hospital-Jazan
Abdulrahman Yahya Salem Almalki
Eradh & Mental Health-Jazan
Hossam Mohammed Ahmed Rayyani
Eradh & Mental Health-Jazan
Rawiyah Mohammed Buayti
Eradh & Mental Health-Jazan
Mossa Shadad Abdullh Hakami
King Fahd Centeral Hospital-Jazan
Malak Hussain Ahmed Asiri
Prince sultan ibn Abdulaziz Primary Health Center , Riyadh
How to Cite
Muhammad Abdulrahman Alahmadi, Khaled Mohammed Nasser Awlaqi, Nasser Mohammed Nasser Dhamda, Wed Ali Ibrahem Musayri, Hayt Ali Almashhur, Abdulrahman Yahya Salem Almalki, Hossam Mohammed Ahmed Rayyani, Rawiyah Mohammed Buayti, Mossa Shadad Abdullh Hakami, & Malak Hussain Ahmed Asiri. (2023). VITAMIN D DEFICIENCY AND RELATED DISORDERS & EXTRA-MUSCULOSKELETAL ROLES. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 2137-2143. https://doi.org/10.53555/jptcp.v30i19.4884