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Mahrukh khursheed
Zehra Ashraf
Qurat ul Ain Waseem
Mehwish khan
Wasim Sarwar Bhatti
Nadeem Baloch
Waseem Abbas


Asthma, Eosinophil’s, Exacerbation, Pathogenesis, Prevelance


Eosinophilia is a common feature of asthma exacerbation and has been associated with increased disease severity and poorer treatment outcomes. However, limited data are available on the prevalence of eosinophilia in hospitalized patients with asthma exacerbation in Karachi, Pakistan. This study aimed to determine the prevalence of eosinophilia in this population. A cross-sectional study was conducted in multiple hospitals in Karachi, Pakistan. Patients admitted with a diagnosis of asthma exacerbation were included in the study. Blood samples were collected from each participant, and complete blood count analysis was performed to determine the absolute eosinophil count. Demographic and clinical data were also collected. A total of 70 patients were included in the study. The prevalence of eosinophilia in hospitalized patients with asthma exacerbation was found to be 39. Subgroup analyses based on age, gender, and asthma severity revealed variations in the prevalence of eosinophilia. Additionally, factors such as smoking, air pollution, and obesity were identified as potential contributors to severe asthma exacerbation. This study provides valuable insights into the prevalence of eosinophilia in hospitalized patients with asthma exacerbation in Karachi, Pakistan. The findings highlight the need for targeted interventions to address eosinophilia and its associated factors in order to improve asthma management and treatment outcomes. Further research is warranted to explore the underlying mechanisms and develop personalized approaches for the management of eosinophilic asthma exacerbation in this population.

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